Takotsubo Cardiomyopathy with Guillain-Barré Syndrome

Gill, Daljit S.; Ruiz, Vanessa Goyes; Dean, Ryan; Liu, Kan

doi:10.1080/08998280.2017.11929626

Cited by 6 publications

(2 citation statements)

References 5 publications

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“…As further was been published, it became evident that wall motion abnormalities in TCM have been no longer confined to the apex but could additionally affect more than one segment of the left ventricle. Mayo Clinic criteria to diagnose TCM include mid-segment transitory hypokinesia, dyskinesia, or akinesia of the left ventricle along with or without the involvement of the apex of the heart; localizable wall motility disorders that are not linked to one specific cardiac vessel supply region; the presence of stressful stimulus; no evidence of thrombotic or obstructive coronary artery disease; new EKG changes like ST-segment elevation or T wave abnormalities, and absence of myocardial inflammation or pheochromocytoma [9].…”

Section: Discussionmentioning

confidence: 99%

Takotsubo Cardiomyopathy: A Possible Rare Complication of Guillain-Barré Syndrome

Mohamed¹,

Oshikoya²,

Kumar³

et al. 2023

Cureus

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Dysautonomia is a common and severe complication of Guillain-Barré syndrome (GBS), which may manifest as cardiac arrhythmias, labile blood pressure, diaphoresis, and changes in gastrointestinal motility. Takotsubo cardiomyopathy (TCM) is a life-threatening manifestation of dysautonomia in patients with GBS, which is not widely underlined in the literature. The association between GBS and TCM has been welldocumented in previous studies; however, there are few reported cases with GBS who developed TCM following their diagnosis with GBS. In this case report, we will discuss our experience treating a 59-year-old female patient who became hemodynamically unstable while recovering from an acute GBS infection. She was diagnosed with TCM after undergoing an echocardiogram and coronary angiogram ruling out thrombotic or obstructive coronary disease and myocarditis.

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Section: Discussionmentioning

confidence: 99%

Takotsubo Cardiomyopathy: A Possible Rare Complication of Guillain-Barré Syndrome

Mohamed¹,

Oshikoya²,

Kumar³

et al. 2023

Cureus

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“…To our knowledge, there have only been 12 prior case reports describing the association between TCM and GBS [3,5,6,[9][10][11][12][13][14][15][16][17]. We searched PubMed with the keywords "Guillain Barre Syndrome," "acute inflammatory demyelinating polyradiculoneuropathy," and "Takotsubo Cardiomyopathy" in order to find prior case reports.…”

Section: Discussionmentioning

confidence: 99%

Takotsubo Cardiomyopathy as a Manifestation of Dysautonomia in Guillain-Barré Syndrome: A Case Series and Review of the Literature

Puentes¹,

Teijelo²,

Stiep³

et al. 2021

Cureus

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Guillain-Barré syndrome (GBS) is an inflammatory polyneuropathy that classically presents with low back pain, sensory paresthesias, and rapidly progressive weakness. Patients with GBS can develop dysautonomia, and Takotsubo cardiomyopathy (TCM) is a rare potential manifestation of this dysautonomia. This association has been reported only 12 times in the literature so far, which we review here. We present two cases of GBS associated with TCM, to increase awareness with regard to this comorbid relationship, which would encourage prompt initiation of proper supportive care to avoid morbidity and mortality.We report the case of two patients -a 58-year-old man and a 79-year-old woman -who developed TCM in the setting of axonal variants of GBS. Electrodiagnostic results, cerebrospinal fluid profiles, and echocardiogram findings were consistent with these diagnoses. Both patients were treated with intravenous immunoglobulin (IVIG) in an intensive care unit (ICU) setting. Echocardiogram findings were reversible.TCM should be recognized as a potential complication of GBS in patients with dysautonomia. This case series adds to the sparse body of literature describing the association between these two conditions. It is not clear if patients with axonal variants of GBS are more predisposed to developing TCM; further, larger case series in the future may help identify the risk factors associated with it. We hope to shed more light on this possible association to expedite the diagnosis and management of this condition.

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