Takotsubo Cardiomyopathy

Racial and Ethnic Disparities in Clinical Outcomes among Patients with Takotsubo Syndrome; A Nation-Wide Analysis

“…In summary, in our analysis, we observed that Asian patients with higher socioeconomic status experienced a more significant association with cardiogenic shock and mortality, suggesting that genetic factors may play a more important role in cardiovascular outcomes in this population. Conversely, for Black and Hispanic patients, socioeconomic status cannot be ignored as a crucial determinant of health outcomes, consistent with existing literature 1,16,17 . These observations underscore the complexity highlighted by recent cardiovascular research, which argues that both genetic factors and social determinants of health are integral to understanding disease outcomes 18 .…”

“…Additionally, there is a hypothesis that chronic medical and socioeconomic stressors, which disproportionately affect specific minority racial groups such as Black communities, may influence the severity of Takotsubo syndrome outcomes 16 . It is proposed that the more adverse outcomes observed in these populations could be partially explained by elevated levels of chronic stress, potentially leading to increased catecholamine production 1 . This hypothesis is supported by existing research indicating that the convergence of medical and socioeconomic challenges is more prevalent in certain minority groups and may significantly contribute to the pathophysiology of Takotsubo cardiomyopathy 16,1 .…”

“…It is proposed that the more adverse outcomes observed in these populations could be partially explained by elevated levels of chronic stress, potentially leading to increased catecholamine production 1 . This hypothesis is supported by existing research indicating that the convergence of medical and socioeconomic challenges is more prevalent in certain minority groups and may significantly contribute to the pathophysiology of Takotsubo cardiomyopathy 16,1 .…”

“…Takotsubo syndrome or cardiomyopathy (TTS), first described in Japan in 1990, manifests as transient left ventricular dysfunction triggered by emotional or physical stress, resembling a “Takotsubo” octopus trap 1. This condition predominantly affects postmenopausal women and mimics heart attack symptoms, though it occurs without coronary artery obstruction 1,2 . The underlying mechanisms of TTS are not fully understood.…”