Takotsubo syndrome and cancer, clinical and prognostic implications, insights of RETAKO

Núñez‐Gil, Iván J.; Vedia, Óscar; Almendro‐Delia, Manuel; Raposeiras‐Roubín, Sergio; Sionís, Alessandro; Martín-García, Agustín; Martín-García, Ana; Andrés, Mireia; Blanco, Emilia; Miguel, Irene Martín de; Uribarri, Aitor; Corbí-Pascual, Miguel; Feltes, Gisela; Bosch, Xavier; Fabregat-Andrés, Óscar; López-País, Javier; Sánchez-Grande-Flecha, Alejandro; Guillen-Marzo, Marta

doi:10.1016/j.medcle.2020.01.017

Cited by 7 publications

(10 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The majority of current studies suggest that older TCM patients have worse long-term outcomes than younger patients. 22,26,27,41,42,44,[47][48][49]55,56,62,[71][72][73][74][75][76][77][78] Cammann et al found that elderly patients with TCM (≥75 years old) had a higher long-term (>60 days) mortality rate (P < 0.001) than younger (≤50 years old) and middle-age patients (51 to 74 years old). 27 Similarly, another study found that older TCM patients had a higher 1 year mortality rate in both primary (12.5% in ≥85 years old vs. 7.0% in 75-84 vs. 5.3% in 65-74, P < 0.05) and secondary TCM patients (16.0% vs. 11.6% vs. 9.6%, P < 0.05), in a large sample of 19 966 TCM patients.…”

Section: Agementioning

confidence: 99%

“…29 Some other studies found DM to be a predictor of mortality, especially long-term mortality, in TCM patients. 40,41,44,55,74,77,78,88 For example, one retrospective study by Kato et al found that TCM patients with a history of DM had more in-hospital complications (pulmonary oedema, cardiogenic shock, sustained VT or VF, complete atrioventricular block, thromboembolism, cardiac rupture, and cardiac death) (OR 2.92, 95% CI 1.01-8.41). 88 Another study by Núñez-Gil et al of 1097 TCM patients found that DM was associated with long-term mortality (median followup = 27.5 months) (HR 2.17, 95% CI 1.41-3.34).…”

Section: Diabetes Mellitusmentioning

confidence: 99%

“…88 Another study by Núñez-Gil et al of 1097 TCM patients found that DM was associated with long-term mortality (median followup = 27.5 months) (HR 2.17, 95% CI 1.41-3.34). 77 In contrast, Madias proposed the interesting hypothesis that DM has a protective effect on TCM patients. Because of diabetic autonomic neuropathy, TCM patients with DM may have a relatively lower level of catecholamine release than patients without DM, thus protecting individuals with DM from adverse events associated with TCM.…”

Section: Diabetes Mellitusmentioning

confidence: 99%

“…The majority of current studies suggest that older TCM patients have worse long‐term outcomes than younger patients. 22 , 26 , 27 , 41 , 42 , 44 , 47 , 48 , 49 , 55 , 56 , 62 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 Cammann et al . found that elderly patients with TCM (≥75 years old) had a higher long‐term (>60 days) mortality rate ( P < 0.001) than younger (≤50 years old) and middle‐age patients (51 to 74 years old).…”

Section: Factors Affecting Prognosis Of Takotsubo Cardiomyopathymentioning

confidence: 99%

“…of 1097 TCM patients found that DM was associated with long‐term mortality (median follow‐up = 27.5 months) (HR 2.17, 95% CI 1.41–3.34). 77 …”

Section: Factors Affecting Prognosis Of Takotsubo Cardiomyopathymentioning

confidence: 99%

See 4 more Smart Citations

Prognostic factors of Takotsubo cardiomyopathy: a systematic review

Teng

et al. 2021

ESC Heart Failure

View full text Add to dashboard Cite

Takotsubo cardiomyopathy (TCM), characterized by reversible ventricular dysfunction, has similar mortality to acute coronary syndrome. With the growing interest in the diagnosis of and interventions for TCM, many risk factors had been found to affect the prognosis of TCM patients, such as age, sex, and pre-existing diseases. Because of the incomplete understanding of the pathophysiologic mechanism in TCM, evidence-based medical therapy for this condition is lacking. Early intervention on risk factors may improve the outcomes of TCM. In this review, we sought to provide up-to-date evidence on risk factors and medical therapies that affect TCM outcome. We found that male sex, physical triggers, and certain comorbidities such as chronic kidney disease, malignant disease, higher body mass index, sepsis, chronic obstructive pulmonary disease, and anaemia were associated with poor TCM prognosis. In contrast, race, hyperlipidaemia, diabetes mellitus, and mood disorders were not clearly associated with TCM prognosis. We also reviewed the effect of medical therapies on TCM outcome, including angiotensin-converting enzyme inhibitors/angiotensin receptor blockers, β-blockers, calcium channel blockers, and statins. The evidence that these medications confer a survival benefit on TCM patients is limited. Understanding these prognostic factors could help develop risk-stratification tools for TCM and establish effective prevention and interventions for this notso-benign condition. Further multicentre clinical studies with large samples and meta-analyses of findings from previous studies are needed to address the inconsistent findings among the many potential risk factors for TCM.

show abstract

Section: Agementioning

confidence: 99%

Section: Diabetes Mellitusmentioning

confidence: 99%

Section: Diabetes Mellitusmentioning

confidence: 99%

Section: Factors Affecting Prognosis Of Takotsubo Cardiomyopathymentioning

confidence: 99%

“…of 1097 TCM patients found that DM was associated with long‐term mortality (median follow‐up = 27.5 months) (HR 2.17, 95% CI 1.41–3.34). 77 …”

Section: Factors Affecting Prognosis Of Takotsubo Cardiomyopathymentioning

confidence: 99%

See 3 more Smart Citations

Prognostic factors of Takotsubo cardiomyopathy: a systematic review

Teng

et al. 2021

ESC Heart Failure

View full text Add to dashboard Cite

show abstract

Mechanism of PDZK1 in Hepatocellular Carcinoma Complicated with Hyperuricemia

Guo

Jiang

Quan

et al. 2022

Journal of Oncology

View full text Add to dashboard Cite

Background. Hepatocellular carcinoma (HCC) is a kind of primary liver cancer that accounts for more than 90% of primary hepatocellular carcinomas. Hyperuricemia is closely related to the development, recurrence, metastasis, and prognosis of cancer. Previous studies have proved that the serum uric acid level can increase the incidence rate and mortality of malignant tumors. However, the specific pathogenesis remains unstudied. Methods. RT-qPCR analysis showed that the mRNA expression of PDZK1 and ABCG2 increased significantly after HCC cells were exposed to different concentrations of soluble uric acid (2.5, 5, 10, 20 mg/dl) for 24 hours. Then, in HCC shRNAs, PDZK1, or over expression PDZK1 were used. CCK8, wound healing, and Transwell assay showed that PDZK1 regulates cell proliferation, invasion, and migration. Flow cytometry results revealed that PDZK1 affects cell apoptosis. Western blot results show that PDZK1 affects the STAT3/C-myc pathway. Then, in vivo tumorigenesis, allopurinol maybe an effective drug to advance: the prognosis of HCC. Results. In our study, RT-qPCR analysis showed that the mRNA expression of PDZK1 and ABCG2 increased significantly after different concentrations of soluble uric acid in HCC. Then, PDZK1 affects the proliferation, migration, and apoptosis of HCC through the STAT3/C-myc pathway. Conclusions. Hyperuricemia response affects the expression of PDZK1; PDZK1 affects the proliferation, migration, and apoptosis through the STAT3/C-myc pathway in hepatocellular carcinoma. It is suggested that PDZK1 maybe closely related to the occurrence, development, and prognosis of HCC and allopurinol maybe have potential anticancer effects.

show abstract

Takotsubo Kardiyomiyopati Üzerine Klinik Deneyimimiz ve Vaka Serimiz

et al. 2022

View full text Add to dashboard Cite

Objective In this study we aimed to evaluate the clinical course and prognosis of Takotsubo Cardiomyopathy cases diagnosed and treated in our clinic. Cases Takotsubo Cardiomyopathy was first described in 1990 by Hikaru Sato et al. The reason why it is called Tako-tsubo cardiomyopathy; This is due to the appearance of the left ventricle resembling the narrow-necked, broad-bottomed container used by Japanese fishermen to catch octopuses. In addition to Takotsubo cardiomyopathy, this syndrome is also called ampulla cardiomyopathy, Human stress cardiomyopathy and Broken heart syndrome. In this study, a series of 7 cases of Takotsubo Cardiomyopathy diagnosed and treated in our clinic are presented and the clinical course and prognosis of the disease are examined. Results The age range of the series, consisting of six female and one male patients, ranged from 57 to 81 years (median age 70). All of the female patients were in the postmenopausal period and physical or emotional stress was found in four of them. Moderate-to-moderate cardiac enzyme elevation was found in all of the patients. While noncritical plaques were detected in the angiography of six patients who underwent coronary angiography and ventriculography, one patient had normal coronaries. During the follow-up, in-hospital death due to non-cardiac causes (Acute Myeloblastic Leukemia) was observed in one of the patients. In the echocardiographic follow-up of six surviving patients, it was observed that the LV ejection fraction was normalized and ballooning regressed within two months. Conclusion The awareness of Takotsubo Cardiomyopathy among cardiology physicians in the world and in our country is increasing. However, information about its prevalence, clinical course and short-term prognosis in our country is insufficient. In the study, a new series was presented in addition to the first data of our country. It is thought that there may be some different physical risk factors that have not yet been identified.

show abstract

Takotsubo syndrome and cancer, clinical and prognostic implications, insights of RETAKO

Cited by 7 publications

References 28 publications

Prognostic factors of Takotsubo cardiomyopathy: a systematic review

Prognostic factors of Takotsubo cardiomyopathy: a systematic review

Mechanism of PDZK1 in Hepatocellular Carcinoma Complicated with Hyperuricemia

Takotsubo Kardiyomiyopati Üzerine Klinik Deneyimimiz ve Vaka Serimiz

Contact Info

Product

Resources

About