Takotsubo Syndrome in the Setting of COVID-19

Minhas, Anum; Scheel, Paul J.; Garibaldi, Brian T.; Liu, Gigi; Horton, Maureen R.; Jennings, Mark T.; Jones, Steven R.; Michos, Erin D.; Hays, Allison G.

doi:10.1016/j.jaccas.2020.04.023

Cited by 137 publications

(176 citation statements)

References 8 publications

Supporting

Mentioning

162

Contrasting

Unclassified

Order By: Relevance

“…In this kind of stress‐related cardiomyopathy, myocardial injury is probably mediated by catecholamine‐induced vascular spasm and/or direct catecholamine action on myocytes. In particular, catecholamine release in response to cytokine storm, or metabolic and emotional distress has been proposed to play a role in COVID‐19‐related Takotsubo syndromes [34–37], consistently with our hypothesis.…”

Section: Sympathetic Overactivity May Exert Significant Detrimental Esupporting

confidence: 86%

Sympathetic activation: a potential link between comorbidities and COVID‐19

et al. 2020

View full text Add to dashboard Cite

In coronavirus disease 2019 (COVID‐19), higher morbidity and mortality are associated with age, male gender, and comorbidities, such as chronic lung diseases, cardiovascular pathologies, hypertension, kidney diseases, diabetes mellitus, and obesity. All of the above conditions are characterized by increased sympathetic discharge, which may exert significant detrimental effects on COVID‐19 patients, through actions on the lungs, heart, blood vessels, kidneys, metabolism, and/or immune system. Furthermore, COVID‐19 may also increase sympathetic discharge, through changes in blood gases (chronic intermittent hypoxia, hyperpnea), angiotensin‐converting enzyme (ACE)1/ACE2 imbalance, immune/inflammatory factors, or emotional distress. Nevertheless, the potential role of the sympathetic nervous system has not yet been considered in the pathophysiology of COVID‐19. In our opinion, sympathetic overactivation could represent a so‐far undervalued mechanism for a vicious circle between COVID‐19 and comorbidities.

show abstract

Section: Sympathetic Overactivity May Exert Significant Detrimental Esupporting

confidence: 86%

Sympathetic activation: a potential link between comorbidities and COVID‐19

et al. 2020

View full text Add to dashboard Cite

show abstract

“…To date, few rare clinical cases report TTS cases during COVID-19. 9,10 In our tertiary centre, we observed from 1 March 2020 to 15 April 2020 a relatively stable incidence of TTS in comparison to the same period during the previous years. On the contrary, we observed a drop of approximately 30% of the incidence of ACS cases ( Table 1).…”

Section: Impact Of Covid-19 Pandemic On Tts Occurrencementioning

confidence: 55%

COVID‐19 pandemic: no increase of takotsubo syndrome occurrence despite high‐stress conditions

2020

View full text Add to dashboard Cite

“…Cardiac complications from COVID-19 may manifest as myocarditis, myocardial infarction, arrhythmias, or stress cardiomyopathy. [1][2][3] In this report, we present a case of acute right ventricular (RV) failure as a contributing factor for hemodynamic collapse in a patient with COVID-19.…”

Section: Introductionmentioning

confidence: 99%