Talampicillin: a new derivative of ampicillin.

Leigh, D. A.; Reeves, D. S.; Simmons, Kate; Thomas, Ayogu; Wilkinson, P. J.

doi:10.1136/bmj.1.6022.1378

Cited by 45 publications

(13 citation statements)

References 3 publications

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“…Similar numbers, for the first, to those found by Verbist [9], Wilkinson et al [10] and Leigh et al [6] and apparently dif ferent for the second. If we consider, how ever, the conditions of the study concerned (food reception, 1 h after drug administra tion), we see that the number is in the logi cal position between 41.5°/o (volunteers in fast state and food reception 2 h thereafter) and 23-25% (reception of food immediately before drug administration).…”

Section: Pharmacological Resultssupporting

confidence: 79%

Comparative Pharmacoclinical Evaluation between Talampicillin and Ampicillin in Urinary Infections

Mallo¹,

Dalet²

1981

Chemotherapy

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500 mg of powdered ampicillin (AMP; activity 108%) and 325 mg of talampicillin chlorhydrate (TMP; equivalent to 200 mg ampicillin with an activity of 100%) were administered orally to two groups of 15 fasting patients selected at random. Blood samples were collected after ½, 1, 2, 4 and 6 h and urine samples after 1, 2, 4 and 6 h. The AMP concentrations were determined by the microbiologic method. All patients received food 1 h after the drugs administration. Urine samples were taken daily for the bacteriologic examination. The maximum seric peak for TMP was 4.2 µg/ml at ½ h and for AMP of 4.6 µg/ml after 1 h. It was stated that TMP is absorbed more quickly than AMP and it was not affected by the presence of food. Nevertheless, no differences were observed in the results of the clinical study.

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Section: Pharmacological Resultssupporting

confidence: 79%

Comparative Pharmacoclinical Evaluation between Talampicillin and Ampicillin in Urinary Infections

Mallo¹,

Dalet²

1981

Chemotherapy

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“…In previous studies (Friedman et al, 1980;Joshi et al, 1980) ampicillin has been given for 10-14 days before blood samples were taken and it is known that significant ampicillin resistance can develop after only 2-3 days of treatment (Leigh et al, 1976). In the study reported here, ampicillin was given for 8 daysthe usual length of course in clinical practice, and blood sampling was started after 4 days of ampicillin therapy.…”

Section: Discussionmentioning

confidence: 99%

The effects of ampicillin oral contraceptive steroids in women.

Back¹,

Breckenridge²,

MacIver³

et al. 1982

Brit J Clinical Pharma

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1 Thirteen women taking long term oral contraceptive steroids were studied while taking ampicillin (500 mg three times daily) and compared to a control cycle while not taking ampicillin.2 There were no significant changes in the plasma concentrations of ethinyloestradiol, levonorgestrel, follicle stimulating hormone or progesterone, although lower concentrations of ethinyloestradiol were noted in two women.3 We conclude that most patients taking oral contraceptive steroids do not need to take alternative contraceptive precautions while taking ampicillin.

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“…Studies in man have shown that greater biological availability of ampicillin can be achieved by the oral administration of tal ampicillin than can be achieved by the oral administration of an equivalent dose of am picillin itself [Leigh et al, 1976], Further more, the more complete absorption of tal- ampicillin has been shown to cause a lower incidence of gastro-intestinal side effects than occurs with ampicillin itself [Knudsen and Harding, 1975].…”

Section: Introductionmentioning

confidence: 99%

Bioavailability and Metabolism of Talampicillin

Jones¹,

Langley²,

Lees³

1978

Chemotherapy

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Talampicillin is an ester of ampicillin which is readily hydrolysed on absorption to release ampicillin. It is well absorbed from the gastro-intestinal tract resulting in a greater bioavailability of ampicillin than can be achieved with equivalent doses of ampicillin itself. Dose response studies have confirmed a direct relationship between the dose of talampicillin administered and peak serum ampicillin concentration and urinary excretion of ampicillin. Dosing of ampicillin after food has been shown to adversely affect the total bioavailability of ampicillin. This is not so after dosing with talampicillin. The bioavailability of ampicillin from a 250-mg Talpen® tablet dosed after a large meal was significantly greater than that from 250 mg ampicillin dosed in the fasting state. Studies in volunteer subjects at multiples of the proposed therapeutic dose for periods of up to 28 days have indicated its acceptability, bioavailability and lack of side effects on repeated dosing. The fate of the phthalidyl moiety of talampicillin has been investigated in repeated dose studies and in a single dose study in which radiolabelled talampicillin was administered. The principal metabolite of the phthalidyl moiety in man has been shown to be 2-hydroxymethylbenzoic acid, which is identical to that in experimental animals used for toxicological investigations.

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Talampicillin: a new derivative of ampicillin.

Cited by 45 publications

References 3 publications

Comparative Pharmacoclinical Evaluation between Talampicillin and Ampicillin in Urinary Infections

Comparative Pharmacoclinical Evaluation between Talampicillin and Ampicillin in Urinary Infections

The effects of ampicillin oral contraceptive steroids in women.

Bioavailability and Metabolism of Talampicillin

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