Talaroclauxins A and B: Duclauxin-ergosterol and duclauxin-polyketide hybrid metabolites with complicated skeletons from Talaromyces stipitatus

Adpressins A–G: Oligophenalenone Dimers from Talaromyces adpressus

“…In addition, nine known congeners were identified as macrosporusones A ( 10 ) and B ( 11 ), talaromycesone C ( 12 ), talaromycesone B ( 13 ), bacillisporin B ( 14 ), macrosporusone D ( 15 ), verruculosin B ( 16 ), talaroclauxin E ( 17 ), and duclauxamide C ( 18 ) by comparison of their NMR and HRESIMS data with literature values.…”

“…Fungal aromatic polyketides constitute a large group of natural products with promising biological activities, such as the antifungal griseofulvin, − the PTP1B inhibitor canescone, and the cytotoxic berkelic acid, anthracycline, alternamgin, and penicanesone . The genus Talaromyces is widely distributed in soil, plants, and animals − and is known to produce a variety of aromatic polyketides, such as oligophenalenone dimers. − Oxaphenalenone dimers possess a 6/6/6/5/6/6/6 heptacyclic 6/6/6/5/6/6/6 ring system, formed by connecting two functionalized 2-oxaphenalen-1-one units through two bonds. These compounds have attracted much attention, because of their intriguing structures and significant pharmacological properties, such as cytotoxicity, − antibacterial activity, − and enzyme or protein inhibitory activity. − Gao and co-workers characterized two dux 1 and dux 2 biosynthetic gene clusters from the genome of Talaromyces stipitatus and revealed the key biosynthetic pathway of the duclauxins …”

New Secondary Metabolites from Marine-Derived Fungus Talaromyces minnesotensis BTBU20220184

“…A chemical investigation of Talaromyces species revealed the potential for new bioactive chemical entries [ 12 ]. A panel of new structural classes have been reported from this fungus, including ergosteroids [ 13 , 14 ], meroterpenoids [ 15 ], and pyridone derivatives [ 16 , 17 ]. Nicoletti reviewed the chemical diversity of Talaromyces species from marine environments.…”

Hot off the press

“…Talaroclauxin B 16 , from Talaromyces stipitatus , has an unusual skeleton. 16 Two possible biosynthetic pathways to talaclauxin B 16 from duclauxin and a polyketide precursor have been proposed. Membranaceumone A 17 , from leaves of Calophyllum membranaceum , has an unusual tetracyclic ring system.…”