Talc Deposition in Skin and Tissues Surrounding Silicone Gel-Containing Prosthetic Devices

Kasper, Candace S.; Chandler, Preston James

doi:10.1001/archderm.1994.01690010052006

Cited by 26 publications

(7 citation statements)

References 34 publications

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“…Cutaneous and/or subcutaneous foreign body granulomas caused by talc (magnesium silicate) have been reported for different causes and in diverse circumstances. Thus there are cases described such as granulomas in surgical wounds due to the talc contained in some gloves as a lubricant, 6 or following topical treatment of a wound with antiseptic powder 7 . Some authors have suggested that contamination of surgical implants with talc can induce granuloma formation, such as in the article published by Kasper et al .…”

Section: Discussionmentioning

confidence: 99%

“…Some authors have suggested that contamination of surgical implants with talc can induce granuloma formation, such as in the article published by Kasper et al . referring to mammary implants 6 …”

Section: Discussionmentioning

confidence: 99%

“…Through polarized light examination, the magnesium silicate crystals present a typical morphology in the shape of ‘spicules’, which reveal white birefringence 6,9 . Using electron microscopy, highly electrodense laminar structures can be visualized inside the cytoplasm of histiocytes and epithelioid cells.…”

Section: Discussionmentioning

confidence: 99%

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Foreign body post‐varicella granulomas due to talc

Lázaro¹,

Reichelt²,

Lazaro³

et al. 2005

Acad Dermatol Venereol

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Foreign body granulomas in the skin have been described frequently and may have various causes. Diagnosis is relatively easy in most cases, as most are related to foreign material penetrating into the skin due to different kinds of traumas. We present the case of a boy with multiple facial granulomas, persisting more than 6 months and related to the use of topical anti-pruriginous talc powder applied to papuloexudative lesions caused by varicella. Data gathered in the anamnesis, examination with polarized light and images seen through the electron microscope enabled us to identify the causal agent talc as the inducer of the granulomatous lesions that the patient presented, discarding other types of foreign body granulomas of exogenous origin.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Foreign body post‐varicella granulomas due to talc

Lázaro¹,

Reichelt²,

Lazaro³

et al. 2005

Acad Dermatol Venereol

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“…In general, the formation of foreign-body giant cells (FBGCs) indicates the transition to a chronic inflammatory process [10,19]. Granuloma formation is often a reason for implant rejection [23][24][25][26][27], or additionally may induce latent autoimmune diseases [28]. As the FBGCs persist, unable to resolve the inflammation, cytokines and chemokines are FIGURE 30.1 Schematic representation of the major events occurring from the creation of an incision, to host cell activation and cytokine release, which determine the ongoing inflammatory process.…”

Section: Inflammation and Host Reactionmentioning

confidence: 99%

“…However, the same features may co-exist, attesting simultaneous development of acute and chronic inflammation [20]. Some authors argue [23,[29][30][31] that at the implant site, the foreign body induces chronic stress bringing forward the formation of granulomas. Once a wound is created, the microvasculature is affected and coagulation takes place in the context of acute inflammation.…”

Section: Inflammation and Host Reactionmentioning

confidence: 99%

Testing Natural Biomaterials in Animal Models

Costa-Pinto¹,

Santos²,

Neves³

et al. 2016

Biomaterials From Nature for Advanced Devices and Therapies

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Animal models have been extensively developed in the last decades in biomedical field. Their use has shown particular relevance in fields such as cell biology, genetics, anatomy and development, biochemistry, infection and immunity, cancer research, drugs and vaccine development, tissue engineering and regenerative medicine.Despite major advances regarding in vitro models aiming to mimic the complexity and cellular interaction existing within tissues [1-3], in vivo testing is essential to safely investigate the biological performance of newly developed devices when implanted in a living system. A better characterization of such response at cellular and molecular level is required, and has been extensively investigated in the last decades [4][5][6][7]. However, the complexity of in vivo responses to implanted biomaterials renders this assessment a challenging issue to address. * Both authors equally contributed for the writing of this book chapter.Biomaterials from Nature for Advanced Devices and Therapies, First Edition. Edited by Nuno M. Neves and Rui L. Reis.

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Possible morbidity in women from talc on condoms

Kasper¹

1995

JAMA: The Journal of the American Medical Association

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Talc Deposition in Skin and Tissues Surrounding Silicone Gel-Containing Prosthetic Devices

Cited by 26 publications

References 34 publications

Foreign body post‐varicella granulomas due to talc

Foreign body post‐varicella granulomas due to talc

Testing Natural Biomaterials in Animal Models

Possible morbidity in women from talc on condoms

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