“…Complications from pacemaker implantation are 30% more likely in females than in males (3). The incidence of both venipuncture related injury and cardiac perforation is higher in patients with bullous emphysema, chronic obstructive pulmonary disease (COPD), congenital defects such as persistent left superior vena cava, age >80 years, Caucasian ethnicity, steroid treatment within 7 days, anticoagulant and antiplatelet therapy, urgent surgery, low BMI (<18.5), or agitation (1,8,15,(18)(19)(20). Prior procedures, operation (such as sternotomies), trauma, or irradiation therapy in the affected area, clavicle/chest deformity, and previous fractures, are all significant risk factors.…”