Tale of Viruses in Male Infertility

Das, Shreya; Mondal, Arunima; Samanta, Jayeeta; Chakraborty, Santanu; Sengupta, Arunima

doi:10.1007/978-3-030-89340-8_13

Cited by 2 publications

(4 citation statements)

References 193 publications

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“…The study indicated that the intensity of the viral infection affected the overall quantity, effectiveness, and morphology of sperms in infected males compared with men who were not infected with the virus, which is consistent with the earlier research 26,27,29 . Although a number of studies were unable to detect virus RNA in the sperm and tissues of the reproductive system of patients and the deceased, the cause for this consequence could be the immune reaction against the virus, and this effect may be proportionate to the strength of the immune and inflammatory reactions, which rise in severe cases, especially when there is a cytokine storm, which can cause tissue and cell damage 30,31 …”

Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

“…26,27,29 Although a number of studies were unable to detect virus RNA in the sperm and tissues of the reproductive system of patients and the deceased, the cause for this consequence could be the immune reaction against the virus, and this effect may be proportionate to the strength of the immune and inflammatory reactions, which rise in severe cases, especially when there is a cytokine storm, which can cause tissue and cell damage. 30,31 The study found a high correlation between COVID-19 and some variables of sperm efficacy and age, as well as a correlation between the fertilization factor and the morphology of the sperm, in addition, an important correlation was observed between the existence of pus-filled cells and the ratio of abnormal shaped sperm, and these conclusions support the findings of prior studies on the impact of virus infection and the effect of the immune response on the numbers and proportions of normal sperm. 25,27,28 TA B L E 4 Normality analysis of semen variables in this study…”

Section: Ta B L E 1 the Correlation Between Covid-19 And Vaccination ...mentioning

confidence: 99%

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The influence of SARS‐CoV‐2 on semen parameters of infected infertile male in comparison with those that noninfected

Ali

Atiyah

Yser

et al. 2022

Clinical Laboratory Analysis

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Background: Coronavirus disease (COVID-19) is an infectious disease caused by SARS COV-2 that has spread globally, the virus can cause different pathological alterations in many organs, such as the lung, kidney, and testis. The study aimed to determine the effect of COVID-19 on the seminal fluid parameters of infected infertile males compared with those who are noninfected. Methods:The study was performed in Al-Hussein Teaching Hospital during the period from September to November, 2021 and it involved 318 patients. The patients' info included age, address, and vaccination. The sperm count, activity, and morphology were detected using Computer-assisted semen analysis CASA (Microptic-Spain) according to the WHO manual.Results: There were high significant differences between the infertile males who were infected with COVID-19 and those who were vaccinated (X 2 = 12.509, p = 0.001). A high significant relation (p < 0.001) was recorded between types of infection severity and volume of semen (p < 0.001) and nonprogress life sperm (C) (p < 0.001). While significant differences were shown in the moderate progression sperm (B) (p = 0.012), and morphology (p = 0.02), respectively. High significant differences were reported between the types of infection severity (count of the sperm, presence of pus, B, C and D), (p < 0.001), while a significant difference was shown between severity types in relation to A and morphology of the sperms (p = 0.021 and 0.015), respectively. Conclusion:The severity of COVID-19 has a significant impact on infertility and sperm parameters, particularly progression and sperm morphology, despite the fact that these parameters are unrelated to vaccination.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Section: Ta B L E 1 the Correlation Between Covid-19 And Vaccination ...mentioning

confidence: 99%

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The influence of SARS‐CoV‐2 on semen parameters of infected infertile male in comparison with those that noninfected

Ali

Atiyah

Yser

et al. 2022

Clinical Laboratory Analysis

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“…For those with abnormal sperm quality caused by varicocele, surgery and conservative treatment with medicine can be used to improve sperm quality to achieve natural conception [24][25][26][27][28] . The various anti-infective and antiviral therapies have been studied so far in order to ameliorate reproductive system viral infection in order to combat the harmful consequences leading to male infertility [29,30] . However, there are still a part of asthenospermia with unclear etiology, who have accepted hormonal therapy or empirical treatment.…”

Section: Discussmentioning

confidence: 99%

The effects of L-carnitine and fructose in improved Ham’s F10 on sperm culture in idiopathic severe asthenospermia within 24h

Chang,

Li,

Kang

et al. 2024

Preprint

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Trial designTo study the effects of L-carnitine and fructose on semen parameters of severe asthenospermia patients by sperm culturing in vitro within 24h. We optimized the energy composition and antioxidant substances of sperm culture medium in vitro (based on Ham’s F10 culture medium) by orthogonal test for preparing high quality culture medium. Sperms of 60 patients with idiopathic severe asthenospermia were collected, and cultured in vitro within 24h, by Ham’s F10 culture medium added to different concentrations of L-carnitine and fructose and culture temperature, whose effects on sperm motility were observed to determine which is the most appropriate concentration and temperature.MethodsFor determining the appropriate concentration of L-carnitine and fructose and the suitable culture temperature in Ham’s F10 culture medium, the orthogonal experiments were carried out to optimize above three factors, which had great influence on sperm viability, survival rate, deformity rate and DNA fragmentation index (DFI).ResultsThe final concentration of L-carnitine and fructose was determined in terms of initial tests to assess the effects of different concentrations (4, 8, 12, and 16 mg/ml L-carnitine and 0.125, 0.250, 0.375, and 0.50 mg/ml fructose) on sperm viability and motility in culture. During the operation of processing and culturing sperms in vitro within 24h, orthogonal test showed that sperm viability was better at the final concentration of 8 mg/ml L-carnitine and 0.375 mg/mL fructose in improved Ham’s F10 culture medium at 36.5 ℃.ConclusionIdiopathic severe asthenospermia sperm can be effectively improved by the modified Ham’s F10 culture medium of the final concentration of 8 mg/ml L- carnitine and 0.375 mg/mL fructose in at 36.5 ℃ within 24h, which has shown better culture effect and is superior to Ham’s F10 basic medium.

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Tale of Viruses in Male Infertility

Cited by 2 publications

References 193 publications

The influence of SARS‐CoV‐2 on semen parameters of infected infertile male in comparison with those that noninfected

The influence of SARS‐CoV‐2 on semen parameters of infected infertile male in comparison with those that noninfected

The effects of L-carnitine and fructose in improved Ham’s F10 on sperm culture in idiopathic severe asthenospermia within 24h

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