Tall cell carcinoma with reversed polarity of breast: Sonographic and magnetic resonance imaging findings

Lee, Na Young; Chang, Yun Woo; Lee, Eun Ji; Jin, Yoon

doi:10.1002/jcu.23280

Cited by 3 publications

(1 citation statement)

References 10 publications

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“…TCCRP has been considered to be an invasive tumor with only a few cases reported as carcinoma in situ (still controversial due to improper IHC tests) [1,2,[4][5][6][7][8][9][10][11][12][13][14][15]. In addition, this tumor is underpinned by recurrent nding of IDH2 (hot spot mutations in residue 172) mutations accompanied with genetic alterations in the PI3K signaling pathway, especially PIK3CA [1,16,17].…”

Section: Discussionmentioning

confidence: 99%

A New Subtype of Papillary Ductal Carcinoma in Situ with Tall Cell and Reversed Polarity Morphology: A Rare Case

Zhong,

Chang,

Wang

et al. 2023

Preprint

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Papillary ductal carcinoma in situ (DCIS) is a subtype of DCIS characterized by the neoplastic proliferation of epithelial cells with a papillary structure and confined to the mammary ductal-lobular system. Tall cell carcinoma with reversed polarity (TCCRP) is a rare subtype of invasive breast carcinoma with low malignant potential, which has recently been recognized as a separate entity in the 2019 WHO Classification of breast tumors. Here, we describe the case of a 54-year-old woman with a finding of growing nodular lesion through breast ultrasonographic screenings, whose morphological features, immunohistochemical results, and molecular genetic studies suggest overlapping features of DCIS and TCCRP. Therefore, we hypothesized that it might be a new DCIS subtype with tall cells and reversed polarity of the mammary gland.

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Section: Discussionmentioning

confidence: 99%

A New Subtype of Papillary Ductal Carcinoma in Situ with Tall Cell and Reversed Polarity Morphology: A Rare Case

Zhong,

Chang,

Wang

et al. 2023

Preprint

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An interesting case of tall cell carcinoma of the breast with reverse polarity

Cartlidge,

Verghese

2024

Diagnostic Histopathology

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Case report: Triple-negative breast cancer with low tumour-infiltrating lymphocytes infiltration and good prognosis: a case of Tall Cell Carcinoma with Reversed Polarity and review of the literature

Jiao,

Chen,

Shen

et al. 2024

Front. Oncol.

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BackgroundTriple-negative breast cancer (TNBC) is a great challenge for clinical management due to the high rate of metastatic recurrence and lack of recognised therapeutic targets, while tumour-infiltrating lymphocytes (TILs) infiltration in TNBC has been discovery provides an opportunity for immunotherapy, and studies have suggested that the level of TILs infiltration is positively correlated with TNBC survival. We found a rare case of TNBC with low TILs infiltration but good prognosis, named Tall Cell Carcinoma with Reversed Polarity (TCCRP), and we investigated it from the perspective of TILs infiltration in order to improve the clinical data of TCCRP.Case presentationa 54-year-old woman with a left breast mass, breast ultrasound showed BI-RADS IVb, puncture diagnosis of invasive ductal carcinoma, postoperative pathology showed papillary structure, cubic and high columnar arrangement of cells, nuclei far away from the base, interstitial fibroplasia, diagnosed as TCCRP. Immunohistochemistry revealed that the tumours were triple-negative breast cancer (negative for ER, PR, and HER-2), with a low Ki-67 proliferation index. TILs were < 10%, with a small infiltration of CD4+ and CD8+ T lymphocytes, positive expression of SMA and FAP, and IDH2, PIK3CA gene mutation. The patient underwent postoperative chemotherapy, 11 months follow-up, no recurrence and metastasis.ConclusionTCCRP is a rare TNBC with inert biological behaviours and good prognosis. We found low infiltration of TILs in the pathological tissue of this case, which may be a characteristic of TCCRP, and the presence of Cancer-Associated Fibroblasts (CAF) in the interstitium of the tumour in this case may have suppressed the anti-tumour immunity to some extent, and further studies on the immune characteristics of the tumour microenvironment (TME) in TCCRP are needed.

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Tall cell carcinoma with reversed polarity of breast: Sonographic and magnetic resonance imaging findings

Cited by 3 publications

References 10 publications

A New Subtype of Papillary Ductal Carcinoma in Situ with Tall Cell and Reversed Polarity Morphology: A Rare Case

A New Subtype of Papillary Ductal Carcinoma in Situ with Tall Cell and Reversed Polarity Morphology: A Rare Case

An interesting case of tall cell carcinoma of the breast with reverse polarity

Case report: Triple-negative breast cancer with low tumour-infiltrating lymphocytes infiltration and good prognosis: a case of Tall Cell Carcinoma with Reversed Polarity and review of the literature

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