Tall cell variant of papillary thyroid carcinoma: current evidence on clinicopathologic features and molecular biology

Wang, Xiaofei; Cheng, Wenli; Liu, Chongqing; Li, Jingdong

doi:10.18632/oncotarget.8215

Cited by 65 publications

(67 citation statements)

References 63 publications

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“…Although there is a lack of consensus on whether the TCV of PTC is varied from the classical PTC in terms of tumor size at presentation (10), a previous review revealed that the mean tumor diameter in all cases of the TCV of PTC was 20 mm, by comparison with 19 mm in classical PTC (10). The current series of the TCV of PTC was compared with the two CaFVs to determine if, irrespective of age and size, TCV is more aggressive than its classical and follicular counterparts.…”

Section: Discussionmentioning

confidence: 99%

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Aggressiveness of the tall cell variant of papillary thyroid carcinoma is independent of the tumor size and patient age

et al. 2017

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Abstract. The tall cell variant (TCV) of papillary thyroid carcinoma (PTC) is characterized by tall columnar cells with a height of at least three times their width. TCV usually presents at an older age, has a larger size and exhibits more extrathyroidal extension and metastases than classical PTC. The current study compared TCV with the classical and follicular variants (CaFVs) of PTC to determine if, irrespective of the age at diagnosis and tumor size, TCV is more aggressive than its classical and follicular counterparts. A total of 16 (3.66%) patients with TCV were identified in a series of 437 patients with PTC from the Clinical University Hospital (Santiago de Compostela, Spain) between 1990 and 2010. The patient clinicopathological features and B-Raf proto-oncogene (BRAF) V600E mutational status were compared with 34 cases of CaFVs of PTC matched for tumor size and patient age. The TCV series included 11 females and 5 males aged 15-74 years (median, 57 years). In total, 15 (93.8%) patients underwent total or near-total thyroidectomy, 1 underwent lobectomy and 5 (31.3%) underwent lymph node dissection. In the TCV series, the tumor size ranged from 5-45 mm (median, 19 mm ) and distant metastases (6.2% vs. 0.0%), as compared with the matched patient cohort. In conclusion, the TCV of PTC is frequently associated with BRAF V600E mutation and is more aggressive than the CaFVs of PTC, regardless of tumor size and patient age at diagnosis.

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Section: Discussionmentioning

confidence: 99%

“…Patients with TCV exhibit poorer survival than those with classical PTC (5,10). The tall-cell feature alone remains a significant prognostic factor for disease-specific mortality when the major prognostic factors for thyroid cancer are controlled for, including age and extrathyroidal extension (11).…”

Section: Introductionmentioning

confidence: 97%

Aggressiveness of the tall cell variant of papillary thyroid carcinoma is independent of the tumor size and patient age

et al. 2017

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“…PTC is derived from the follicular epithelium [3] and includes many histological variants such as tall cell, columnar cell, diffuse sclerosing, solid, and hobnail [4, 5]. …”

Section: Introductionmentioning

confidence: 99%

A comparison of the clinicopathological features and prognoses of the classical and the tall cell variant of papillary thyroid cancer: a meta-analysis

et al. 2016

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Papillary thyroid cancer (PTC) accounts for 80–90% of all thyroid malignancies. The tall cell variant (TCV) is a rare aggressive histotype of PTC. We performed a meta-analysis to compare the clinicopathological characteristics and prognostic factors of TCV with those of classical papillary thyroid carcinoma (cPTC). A literature search was performed using the PubMed and EMBASE databases using Medical Subject Headings and keywords. Twenty studies that included 1871 patients with TCV and 75323 patients with cPTC were included in our meta-analysis. Odds ratios and confidence intervals were calculated for each study. Patients with TCV were associated with multifocality, higher TNM stage, extrathyroidal extension, vascular invasion, lymph node metastasis, distant metastasis, BRAF mutation, disease-specific survival, and overall survival. We found that TCV cases were associated with more aggressive clinicopathological characteristics and poorer prognoses than cPTC cases were. Our results suggest that TCV is a high-risk PTC that warrants aggressive treatment and follow-up strategies.

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“…It is composed predominantly of elongated (“tall”) tumor cells (height/width ≥3/1) with abundant dense oxyphilic granular cytoplasm and the typical nuclear changes of PTC . In contrast to conventional PTC, the TCV has a relatively higher prevalence in males and tends to occur in older patients . It often presents at advanced stages and has a higher incidence of local recurrence and distant metastasis .…”

Section: Tall Cell Variantmentioning

confidence: 98%

Update on the cytologic features of papillary thyroid carcinoma variants

Pusztaszeri

Auger

2017

Diagnostic Cytopathology

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Papillary thyroid cancer (PTC), which accounts for 85-90% of all thyroid cancers, is generally an indolent tumor with long term survival rates >95%. A reliable definitive diagnosis of PTC is usually straightforward in fine needle aspirates of conventional PTC whenever the characteristic papillary and/or flat honeycomb sheet-like architecture and the typical nuclear features of chromatin pallor, nuclear enlargement, crowding, grooves and pseudoinclusions are encountered. Conventional PTC, however, has diminished in relative frequency as compared to PTC variants, especially the noninvasive follicular variant of PTC, an indolent tumor which has recently been reclassified as "noninvasive follicular thyroid neoplasm with papillary-like nuclear features" (NIFTP). These PTC variants are characterized by various architecture, cell type and shape, and stromal features, some of which can be recognized cytologically. Awareness of the cytomorphological spectrum and of the characteristic cytological features of these PTC variants is important to avoid diagnostic pitfalls. In this article, we review the different variants of PTC, including their cytomorphologic features, differential diagnosis, and salient molecular features. Diagn. Cytopathol. 2017;45:714-730. © 2017 Wiley Periodicals, Inc.

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Tall cell variant of papillary thyroid carcinoma: current evidence on clinicopathologic features and molecular biology

Cited by 65 publications

References 63 publications

Aggressiveness of the tall cell variant of papillary thyroid carcinoma is independent of the tumor size and patient age

Aggressiveness of the tall cell variant of papillary thyroid carcinoma is independent of the tumor size and patient age

A comparison of the clinicopathological features and prognoses of the classical and the tall cell variant of papillary thyroid cancer: a meta-analysis

Update on the cytologic features of papillary thyroid carcinoma variants

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