Tamarind Seed Xyloglucans Promote Proliferation and Migration of Human Skin Cells through Internalization via Stimulation of Proproliferative Signal Transduction Pathways

Nie, Wei; Deters, Alexandra

doi:10.1155/2013/359756

Cited by 21 publications

(19 citation statements)

References 44 publications

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“…In fact, topical application of heat-killed probiotics, purified compounds, and also in combination with mucosal protectors, is receiving special attention and deserves further studies. The use of mucosal protectors in dermatological diseases is based on their protective barrier properties to avoid skin damage and their role in skin regeneration [4,174].…”

Section: Clinical Benefits Of Tyndallized Bacteria As Probiotics Imentioning

confidence: 99%

Health Benefits of Heat-Killed (Tyndallized) Probiotics: An Overview

Piqué

Berlanga

Miñana-Galbis

2019

IJMS

414

284

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Nowadays, the oral use of probiotics is widespread. However, the safety profile with the use of live probiotics is still a matter of debate. Main risks include: Cases of systemic infections due to translocation, particularly in vulnerable patients and pediatric populations; acquisition of antibiotic resistance genes; or interference with gut colonization in neonates. To avoid these risks, there is an increasing interest in non-viable microorganisms or microbial cell extracts to be used as probiotics, mainly heat-killed (including tyndallized) probiotic bacteria (lactic acid bacteria and bifidobacteria). Heat-treated probiotic cells, cell-free supernatants, and purified key components are able to confer beneficial effects, mainly immunomodulatory effects, protection against enteropathogens, and maintenance of intestinal barrier integrity. At the clinical level, products containing tyndallized probiotic strains have had a role in gastrointestinal diseases, including bloating and infantile coli—in combination with mucosal protectors—and diarrhea. Heat-inactivated probiotics could also have a role in the management of dermatological or respiratory allergic diseases. The reviewed data indicate that heat-killed bacteria or their fractions or purified components have key probiotic effects, with advantages versus live probiotics (mainly their safety profile), positioning them as interesting strategies for the management of common prevalent conditions in a wide variety of patients´ characteristics.

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Section: Clinical Benefits Of Tyndallized Bacteria As Probiotics Imentioning

confidence: 99%

Health Benefits of Heat-Killed (Tyndallized) Probiotics: An Overview

Piqué

Berlanga

Miñana-Galbis

2019

IJMS

414

284

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“…In human skin keratinocytes and fibroblasts, xyloglucan improved keratinocyte and fibroblast proliferation, promoted the cell cycle and stimulated migration and intracellular enzyme activity, thus highlighting a possible role of xyloglucan in skin regeneration [ 71 ].…”

Section: In Vitro Evidence For the Barrier Properties Of Xyloglucamentioning

confidence: 99%

“…These mucoadhesive properties allow xyloglucan formulations to act as a barrier that is capable of reducing bacterial adherence and invasion and preserving tight junctions and paracellular flux, as observed in different in vitro cell models [ 1 , 16 , 17 ]. Xyloglucan has also been seen to have a role in corneal healing and in skin regeneration [ 22 , 71 ]. These favourable in vitro results have been correlated with favourable results in clinical trials in patients with gastroenteritis [ 23 , 24 ], nasal disorders [ 15 ] and dry eye syndrome [ 28 ].…”

Section: Concluding Remarks and Future Perspectivesmentioning

confidence: 99%

Xyloglucan, a Plant Polymer with Barrier Protective Properties over the Mucous Membranes: An Overview

Piqué

Gómez‐Guillén

Montero

2018

IJMS

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Disruption of the epithelial barrier function has been recently associated with a variety of diseases, mainly at intestinal level, but also affecting the respiratory epithelium and other mucosal barriers. Non-pharmacological approaches such as xyloglucan, with demonstrated protective barrier properties, are proposed as new alternatives for the management of a wide range of diseases, for which mucosal disruption and, particularly, tight junction alterations, is a common characteristic. Xyloglucan, a natural polysaccharide derived from tamarind seeds, possesses a “mucin-like” molecular structure that confers mucoadhesive properties, allowing xyloglucan formulations to act as a barrier capable of reducing bacterial adherence and invasion and to preserve tight junctions and paracellular flux, as observed in different in vitro and in vivo studies. In clinical trials, xyloglucan has been seen to reduce symptoms of gastroenteritis in adults and children, nasal disorders and dry eye syndrome. Similar mucosal protectors containing reticulated proteins have also been useful for the treatment of irritable bowel syndrome and urinary tract infections. The role of xyloglucan in other disorders with mucosal disruption, such as dermatological or other infectious diseases, deserves further research. In conclusion, xyloglucan, endowed with film-forming protective barrier properties, is a safe non-pharmacological alternative for the management of different diseases, such as gastrointestinal and nasal disorders.

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“…Tamarind seeds are the most abundant source of xyloglucan and soluble fiber in nature (Kozioł et al, 2015). Xyloglucans are one of the two major hemicelluloses in plants (Nie & Deters, 2013). TXG is edible, biocompatible, bioavailable and mucoadhesive, highly substituted, food grade and versatile use in foods (Mishra & Malhotra, 2009).…”

Section: Introductionmentioning

confidence: 99%

Mucoadhesive role of tamarind xyloglucan on inflammation attenuates ulcerative colitis

Periasamy

Lin

Nagarajan

et al. 2018

Journal of Functional Foods

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Tamarind xyloglucan (TXG) is edible, bioavailable and mucoadhesive polysaccharide. The aim of this study was (i) to investigate molecular docking studies on the interaction of TXG to MUC1 and cytokine receptors and (ii) to assess the mucoadhesive role of TXG in UC. In vivo study: C57Bl6 mice were administered with DSS 3% (w/v) in drinking water; TXG 100 or 300 mg/kg/day was given orally for 7 days simultaneously. TXG consistently binds to MUC1 and cytokine receptors in molecular docking studies. TXG decreased the expression of MUC1 and MUC2. The mucoadhesive ability of TXG decreased IL-1β and IL-6 levels. Furthermore, TXG decreased the expression of TLR4, MyD88, I-κB and NF-κB thereby attenuating inflammation via TLR4/NF-κB signaling pathway. TXG mucoadhesion to MUC1 played a pivotal role in attenuating inflammation. To conclude, the mucoadhesive role of TXG is important in the attenuation of inflammation and healing of UC.

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Tamarind Seed Xyloglucans Promote Proliferation and Migration of Human Skin Cells through Internalization via Stimulation of Proproliferative Signal Transduction Pathways

Cited by 21 publications

References 44 publications

Health Benefits of Heat-Killed (Tyndallized) Probiotics: An Overview

Health Benefits of Heat-Killed (Tyndallized) Probiotics: An Overview

Xyloglucan, a Plant Polymer with Barrier Protective Properties over the Mucous Membranes: An Overview

Mucoadhesive role of tamarind xyloglucan on inflammation attenuates ulcerative colitis

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