Tamarix aphylla (L.) Karst. Phytochemical and Bioactive Profile Compilations of Less Discussed but Effective Naturally Growing Saudi Plant

Ali, Mohammed Ashraf; Alhazmi, Hassan A.; Ansari, S. H.; Hussain, Arshad; Ahmad, Sarfaraz; Alam, Sarfaraz; Ali, Sajid; El-Sharkawy, Karam Ahmed; Hakeem, Khalid Rehman

doi:10.1007/978-3-030-04408-4_16

Cited by 16 publications

(19 citation statements)

References 25 publications

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“…Fraction 9 (4.3 g) was loaded onto an NPS column (75 × 3.5 cm) and eluted with a gradient mobile phase system of EtOAc: n-hexane (2,4,6,8,10,12,14,16,18,20,25, . .…”

Section: Extraction and Isolationmentioning

confidence: 99%

“…Tamarix aphylla L., is a promising natural source known for its metabolite diversity and high potential for medicinal and pharmaceutical leads. The aqueous ethanolic extract of T. aphylla L. galls has been recommended as an anti-inflammatory and antipyretic mediator [16], therefore, in the present study, we tested this notion by investigating the constituents of the aerial parts of T. aphylla L. and evaluated their anti-inflammatory in vitro activity.…”

Section: Introductionmentioning

confidence: 99%

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Anti-Inflammatory Principles from Tamarix aphylla L.: A Bioassay-Guided Fractionation Study

et al. 2020

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Natural products have served as primary remedies since ancient times due to their cultural acceptance and outstanding biodiversity. To investigate whether Tamarix aphylla L. modulates an inflammatory process, we carried out bioassay-guided isolation where the extracts and isolated compounds were tested for their modulatory effects on several inflammatory indicators, such as nitric oxide (NO), reactive oxygen species (ROS), proinflammatory cytokine; tumour necrosis factor (TNF-α), as well as the proliferation of the lymphocyte T-cells. The aqueous ethanolic extract of the plant inhibited the intracellular ROS production, NO generation, and T-cell proliferation. The aqueous ethanolic crude extract was partitioned by liquid-liquid fractionation using n-hexane (n-C6H6), dichloromethane (DCM), ethyl acetate (EtOAc), n-butanol (n-BuOH), and water (H2O). The DCM and n-BuOH extracts showed the highest activity against most inflammatory indicators and were further purified to obtain compounds 1–4. The structures of 3,5-dihydroxy-4’,7-dimethoxyflavone (1) and 3,5-dihydroxy-4-methoxybenzoic acid methyl ester (2) from the DCM extracts; and kaempferol (3), and 3-hydroxy-4-methoxy-(E)-cinnamic acid (4) from the n-BuOH extract were elucidated by different spectroscopic tools, including MS, NMR, UV, and IR. Compound 2 inhibited the production of ROS and TNF-α, whereas compound 3 showed inhibitory activity against all the tested mediators. A better understanding of the potential aspect of Tamarix aphylla L. derivatives as anti-inflammatory agents could open the door for the development of advanced anti-inflammatory entities.

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“…Fraction 9 (4.3 g) was loaded onto an NPS column (75 × 3.5 cm) and eluted with a gradient mobile phase system of EtOAc: n-hexane (2,4,6,8,10,12,14,16,18,20,25, . .…”

Section: Extraction and Isolationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory Principles from Tamarix aphylla L.: A Bioassay-Guided Fractionation Study

et al. 2020

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“…Another appealing attribute for accepting a comprehensive collection of herbal medications is cost-effectiveness. The use of herbal medicines is historical, but there is a space in ancient traditional practices fulfilled by alternative medicine and complementary medicines incorporating new technologies [ 4 , 5 , 6 ]. Therefore, we should continue to research new plant-based therapy from the vast reservoir of nature [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Pharmacological Efficacy of Tamarix aphylla: A Comprehensive Review

Alshehri

Wahab

Abullais

et al. 2021

Plants

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Tamarix aphylla is a well-known species of the genus Tamarix. T. aphylla (Tamaricaceae) is a perennial tree in Asia, the Middle East, and Central Africa. It is used as a carminative diuretic in tuberculosis, leprosy, and hepatitis. Various pharmacological properties have been shown by T. aphylla, such as antidiabetic, anti-inflammatory, antibacterial, antifungal, anticholinesterase, and wound-healing activity. However, T. aphylla has not received much attention for its secondary metabolites and bioactive constituents. Research has shown that this plant has hidden potential that needs to be explored. This review aims to cover botanical classification, geographical distribution, taxonomy, ethnobotanical uses, and the phytochemical compounds found in T. aphylla. The toxicology and pharmacological effects of T. aphylla are also discussed. We examined various scholarly resources to gather information on T. aphylla, including Google Scholar, Scopus, Science Direct, Springer Link, PubMed, and Web of Science. The finding of this work validates a connection between T. aphylla in conventional medicine and its antidiabetic, antibacterial, anti-inflammatory, wound-healing, antifungal, anticholinesterase, and other biological effects. T. aphylla’s entire plant (such as bark, leaves, fruits) and root extracts have been used to treat hypertension, stomach discomfort, hair loss, cough and asthma, abscesses, wounds, rheumatism, jaundice, fever, tuberculosis, and gum and tooth infection. The phytochemical screening revealed that noticeably all extracts were devoid of alkaloids, followed by the presence of tannins. In addition, different parts have revealed the existence of steroids, flavonoids, cardiac glycosides, and byproducts of gallic acid and ellagic acid. T. aphylla has shown many valuable activities against different diseases and supports its traditional uses. Therefore, high-quality preclinical research and well-designated clinical trials are needed to establish the efficacy and safety of this plant in humans.

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“…These plants are also normally used as part of traditional herbal remedies with every indigenous system of medicine and are of high folk-lore reputation in the parts of the world they perennially survive. In this region, the locals, and nomadic people, frequently use these plants as a remedy for certain physiological conditions, hormonal disorders based on symptomatic observations, and the diseases identified through primitive diagnosis, as well as in wounds, burns, cuts, bad skin conditions, pains, swellings, and joint-swellings [ 17 , 18 , 19 , 20 , 21 ]. These plants are also a rich source of alternate nutrition for animals as well as a livestock-feed at times as a substitute for regular but standby green forage, the berseem, Trifolium alexandrinum .…”

Section: Introductionmentioning

confidence: 99%

Anti-Microbial, Anti-Oxidant, and α-Amylase Inhibitory Activity of Traditionally-Used Medicinal Herbs: A Comparative Analyses of Pharmacology, and Phytoconstituents of Regional Halophytic Plants’ Diaspora

Al-Omar

Mohammed

et al. 2020

Molecules

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Halophytes are the category of plants growing under harsh conditions of super-salinity, and are wide-spread in the coastal Mediterranean climatic conditions and desert oasis. They are adept at surviving through maintaining excessive production of enzymatic, and non-enzymatic secondary metabolites, especially phenolics and flavonoids that primarily work as anti-oxidants and phytoalexins. Five major halophyte species growing in the kingdom’s Qassim’s high-salted desert regions were investigated for confirming their traditionally used biological activity of sugar-control and anti-infectious properties. In this context, the comparative presence of phenolics, and flavonoids together with anti-microbial, anti-oxidants, and the anti-diabetic potentials of the plants’ extracts were investigated through the α-amylase inhibition method. The highest concentrations of phenolics and flavonoids were detected in Salsola imbricata (360 mg/g of the extract as Gallic-Acid-Equivalents/GAE, and 70.5 mg/g of the extract as Rutin-Equivalents/RE). In contrast, the lowest concentrations of phenolics and flavonoids were detected in Salsola cyclophylla (126.6 mg/g GAE, and 20.5 mg/g RE). The halophytes were found rich in trace elements, a factor for water-retention in high-salinity plants, wherein iron and zinc elements were found comparatively in higher concentrations in Aeluropus lagopoides (4113 µg/kg, and 40.1 µg/kg, respectively), while the copper was detected in higher concentration (11.1 µg/kg) in S. imbricata, analyzed through Inductively Coupled Plasma Optical Emission Spectrometric (ICP-OES) analysis. The anti-oxidant potentials and α-amylase enzyme inhibition-based anti-diabetic activity of S. imbricata was significantly higher than the other halophytes under study, wherein S. cyclophylla exhibited the lowest level of α-amylase inhibition. The maximum DPPH radicals’ (52.47 mg/mL), and α-amylase inhibitions (IC50 22.98 µg/mL) were detected in A.lagopoides. The anti-microbial activity against the Methicillin-Resistant Staphylococcus aureus was strongly exhibited by Zygophyllum simplex (33 mm Inhibition Zone-Diameter, 50 µg/mL Minimum-Inhibitory-Concentration), while Escherichia coli, Enterococcus faecalis, and Candida albicans growths were moderately inhibited by Tamarix aphylla. The current findings exhibited significant differences among the locally distributed halophytic plants species with regards to their bioactivity levels, anti-oxidant potentials, and the presence of trace elements. The ongoing data corroborated the plants’ traditional uses in infections and diabetic conditions. The enhanced local distribution of the plants’ diaspora and higher density of occurrence of these plants species in this region, in comparison to their normal climatic condition’s counterparts, seemed to be affected by humans’ use of the species as part of the traditional and alternative medicine over a period of long time.

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Tamarix aphylla (L.) Karst. Phytochemical and Bioactive Profile Compilations of Less Discussed but Effective Naturally Growing Saudi Plant

Cited by 16 publications

References 25 publications

Anti-Inflammatory Principles from Tamarix aphylla L.: A Bioassay-Guided Fractionation Study

Anti-Inflammatory Principles from Tamarix aphylla L.: A Bioassay-Guided Fractionation Study

Pharmacological Efficacy of Tamarix aphylla: A Comprehensive Review

Anti-Microbial, Anti-Oxidant, and α-Amylase Inhibitory Activity of Traditionally-Used Medicinal Herbs: A Comparative Analyses of Pharmacology, and Phytoconstituents of Regional Halophytic Plants’ Diaspora

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