Abstract:Glioblastoma is the most common and aggressive primary brain tumor in adults. Despite treatment through surgery, irradiation and chemotherapy all patients suffer recurrence of treatment-resistant tumors and the survival prognosis remains poor. The recurrence of tumors is driven by the invasive nature of the tumor and appears to be related to cells with stem like characteristics that are present in perivascular and hypoxic niches. Previous studies from our lab showed that astrocytes grown in hypoxic or irradiat… Show more
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