The design of embedded systems from multiple views and heterogeneous models is ubiquitous in avionics as, in particular, different high-level modeling standards are adopted for specifying the structure, hardware and software components of a system. The system-level simulation of such composite models is necessary but difficult task, allowing to validate global design choices as early as possible in the system design flow. This paper presents an approach to the issue of composing, integrating and simulating heterogeneous models in a system co-design flow. First, the functional behavior of an application is modeled with synchronous data-flow and statechart diagrams using Simulink/Gene-Auto. The system architecture is modeled in the AADL standard. These highlevel, synchronous and asynchronous, models are then translated into a common model, based on a polychronous model of computation, allowing for a Globally Asynchronous Locally Synchronous (GALS) interpretation of the composed models. This translation is implemented as an automatic model transformation within Polychrony, a toolkit for embedded systems design. Simulation, including profiling and value change dump demonstration, has been carried out based on the common model within Polychrony. An avionic case study, consisting of a simplified doors and slides control system, is presented to illustrate our approach.