Tamoxifen use correlates with increased risk of hip fractures in older women with breast cancer: A case–control study in Taiwan

Abstract

Aim This study aimed to evaluate the association between tamoxifen use and hip fractures in older women with breast cancer in Taiwan. Methods We carried out a retrospective nationwide case–control study using the database of the Taiwan National Health Insurance Program. A total of 762 female patients with breast cancer aged ≥65 years newly diagnosed with hip fractures from 2000 to 2011 were identified for inclusion in the study. Additionally, 7620 female patients with breast cancer aged ≥65 years without hip fractures were randomly selected as controls. Patients were defined as having used tamoxifen if they had an existing prescription for tamoxifen before the index date. Patients were defined as having never used tamoxifen if they had never been given a prescription for tamoxifen before the index date. We used an unconditional logistic regression model to calculate the odds ratio and 95% confidence interval for the association between tamoxifen use and risk of hip fractures. Results After adjustment for confounding variables, compared with patients who did not use tamoxifen, the adjusted odds ratio of hip fracture was 2.29 for those who had used tamoxifen (95% confidence interval 1.92, 2.72). Furthermore, adjusted odds ratios were 2.74 (95% confidence interval 2.19, 3.42) among patients with a cumulative duration of tamoxifen use of >3 years. Conclusion Tamoxifen use is associated with increased risk of hip fractures among older women with breast cancer in Taiwan. Geriatr Gerontol Int 2019; 19: 56–60.

Sociodemographic and Lifestyle Risk Factors Associated with Fragility Hip Fractures: A Systematic Review and Meta-Analysis

“…Notably, an intriguing pattern emerged when analyzing recent studies. Pooled data from these studies consistently indicate a significant association between age over 85 and hip fractures (pooled OR 1.75; 95% CI 1.28 to 2.38; p < 0.01) [32,38,66] (Figure 3).…”

“…These factors collectively contribute to an increased risk of falls and subsequent hip fractures. A total of 29 out of the 34 studies that reported the mean age of both the hip fracture and non-fracture groups indicated significantly higher ages within the fracture group (pooled Cohen's d 0.63; 95% CI 0.44 to 0.82; p < 0.01) [6,10,[18][19][20][21][22][23][24]29,[32][33][34]36,39,41,43,44,[47][48][49][50]52,53,57,[59][60][61][62][63]65,69,71,74] (Figure 2). This finding aligns with earlier research highlighting decreased BMD with advancing age and heightened susceptibility to fractures among older, more vulnerable groups.…”

“…Figure 2.Forest plot demonstrating pooled effect size of age as a risk factor for osteoporotic hip fracture. Box and whiskers represent each study with its 95% confidence interval and the green diamond represents the overall effect size[6,10,[18][19][20][21][22][23][24]29,[32][33][34]36,39,41,43,44,[47][48][49][50]52,53,57,[59][60][61][62][63]65,69,71,74].…”

Risk of herpes zoster among patients with predialysis chronic kidney disease in a cohort study in Taiwan

“…Comorbidities were included as follows: alcohol‐related disease, cancer, cardiovascular disease (including coronary artery disease, heart failure, cerebrovascular disease and peripheral atherosclerosis), chronic liver disease (including cirrhosis, hepatitis B infection, hepatitis C infection and other chronic hepatitis), chronic obstructive pulmonary disease and diabetes mellitus. All comorbidities studied were diagnosed based on ICD‐9 codes, which have been well examined in previous studies 21‐25 …”

Prediction of recurrence-associated death from localized prostate cancer with a charlson comorbidity index–reinforced machine learning model

“…Yang et al recognized that CCI is a good predictor for NHIRD patients with lung cancer using a Cox regression model (16). Successively, fine results have been reported in NHIRD-related literature relating to breast cancer [17, 18] and hepatoma [19]. Prostate cancer–related issues with NHIRD have also been published [20, 21, 22].…”