Tamponade is one of the major complications of pericarditis which is immediately life threatening. The objective of the study was to evaluate the diagnostic and evolutive aspects of pericardial tamponade in a cardiology department of Dakar.We included 40 patients who had a tamponade with a file that could be exploited over a period of 3 years and 6 months (January 2010 to June 2014). The mean age of the patients was 41 years (range between 15 and 80 years). There was a male predominance with a sex ratio (23/17) of 1.35.Signs were dominated by dyspnea (95.0%), pain (85.0%) and fever (40%). Signs of poor hemo dynamic tolerance were evidenced by weak peripheral pulses (21.16%), paradoxical pulse (5%), and hypotension and/or shock (15.0%).The diagnostic means, besides the clinic examination, was mainly by conducting an echocardiography. Thus, there was a proto-mesodiastolic collapse of RV in 82.5% of cases, a telediastolic collapse of the right atrium in 87.5% of cases, a fibrin network in 55% of cases.Emergency treatment with per cutaneous pericardiocentesis was performed in all our patients using the subxiphoid approach. There was a favorable evolution in 77.5% of cases. Were corded 8 cases (or 20%) of death in all admitted cases.Pericardial tamponade is a medical emergency. The diagnosis is easy using echocardiography but the etiological diagnosis is always problematic in our working context.