Tamsulosin in urology: beyond benign prostatic hyperplasia

Prabhu, Girish; Prajapati, Hiren; Chaturvedi, Alok; Dave, Nilanj; Jain, Amit

doi:10.1007/s40267-019-00611-1

Cited by 4 publications

(5 citation statements)

References 26 publications

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“…All treatment options were discussed extensively with the patient despite his reluctance to receive/undergo endogenous agents or procedures. However, a temporary prescription of the spasmolytic agent tamsulosin was sufficient for protecting against possible urine retention [8]. This regimen was continued for 90 days with serial follow-ups at the urology clinic until discontinuation.…”

Section: Case Reportmentioning

confidence: 99%

Severe penile torsion of 180 degrees in an adult patient: a uro-radiological case report

Alzahrani,

Al-Sharydah,

Alkhamis

et al. 2023

JMedLife

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Penile torsion is the abnormal three-dimensional twisting of penile corporal bodies. It can be classified as mild, moderate, or severe, depending on the degree of torsion. Severe penile torsion (>90°) is a very rare condition, with an estimated incidence of 0.4%-1% among all penile torsion cases. Our patient was a 37-year-old man complaining of a 2-year history of lower urinary tract symptoms. These symptoms appeared after the patient sustained an iatrogenic injury during Foley catheter insertion. Physical examination incidentally revealed an obvious counterclockwise penile rotation of 180°. Several theories have been proposed to explain the etiology of penile torsion, including theories based on genetic factors, abnormal urethral development, and abnormal attachment of the dartos fascia to the skin. Penile torsion may be associated with other penile anomalies, including chordee, hypospadias, and epispadias; however, it is often detected as an isolated finding. Clinical examination is sufficient to confirm its diagnosis without the need for further imaging. While no standardized procedure has been indicated for all penile torsion cases, the severity of torsion and the presence of other anomalies determine the most suitable procedure. No reports on the imaging features of penile torsion (irrespective of the degree of torsion) are available. We present the first such report on the imaging features, including advanced magnetic resonance imaging findings, of a 180° penile torsion in an adult patient.

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Section: Case Reportmentioning

confidence: 99%

Severe penile torsion of 180 degrees in an adult patient: a uro-radiological case report

Alzahrani,

Al-Sharydah,

Alkhamis

et al. 2023

JMedLife

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“…This strategy was applied in the formal synthesis of ( R , R )-formoterol ( 14 ) and ( R )-tamsulosin ( 15 ) (Scheme 5) which have been used as therapeutic drugs for many years [40–41]. They are structurally related since they contain an ( R )-1-aryl-2-propanamine moiety.…”

Section: Reviewmentioning

confidence: 99%

N-(1-Phenylethyl)aziridine-2-carboxylate esters in the synthesis of biologically relevant compounds

Głowacka¹,

Trocha²,

Wróblewski³

et al. 2019

Beilstein J. Org. Chem.

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Since Garner’s aldehyde has several drawbacks, first of all is prone to racemization, alternative three-carbon chirons would be of great value in enantioselective syntheses of natural compounds and/or drugs. This review article summarizes applications of N-(1-phenylethyl)aziridine-2-carboxylates, -carbaldehydes and -methanols in syntheses of approved drugs and potential medications as well as of natural products mostly alkaloids but also sphingoids and ceramides and their 1- and 3-deoxy analogues and several hydroxy amino acids and their precursors. Designed strategies provided new procedures to several drugs and alternative approaches to natural products and proved efficiency of a 2-substituted N-(1-phenylethyl)aziridine framework as chiron bearing a chiral auxiliary.

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“…Tamsulosin, a highly selective α1-blocker, lowers the tone of the smooth muscle contraction in the prostate, urethra, and bladder neck, reducing urine flow resistance [ 3 ]. It has more affinity for α1A receptors than for α1B receptors.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Tamsulosin 0.4 mg versus 0.8 mg in management of lower urinary tract symptoms due to benign prostatic enlargement

Osman,

Elawady,

Fawaz

et al. 2024

Int Urol Nephrol

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Purpose To compare the efficacy and the safety of Tamsulosin 0.4 mg/day and 0.8 mg/day in patients suffering from lower urinary tract symptoms due to benign prostatic obstruction. Patients and Methods A prospective interventional, double-blinded, controlled study was carried out on 93 patients who met the criteria and divided randomly into two groups: group A for Tamsulosin 0.4 mg/day and group B for Tamsulosin 0.8 mg/day. International prostate symptom score, post void residual urine volume, and maximum flow rate of urine were assessed before and after 4 weeks of treatment. Results Both study groups showed a significant reduction in storage sub-score but only frequency was significantly reduced in group B (P < 0.001). On the other hand, Tamsulosin 0.8 mg was superior to Tamsulosin 0.4 mg regarding voiding sub-score except for straining (P = 0.325). Accordingly, the total international prostate symptom score was significantly improved in group B versus group A (P < 0.001). Furthermore, maximum flow rate and post-void residual urine volume were notably improved in Group B as compared to Group A (P < 0.001). Of all adverse events only dizziness was noted to be statistically significant in Group B versus Group A (P < 0.001). Conclusion Tamsulosin 0.8 mg has shown better outcomes in treating patients who suffer from lower urinary tract symptoms due to benign prostatic enlargement than Tamsulosin 0.4 mg, and besides that, it is well tolerated. Trial registration number M S 292/2020, SID: 373, date: 22/4/2020.

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Tamsulosin in urology: beyond benign prostatic hyperplasia

Cited by 4 publications

References 26 publications

Severe penile torsion of 180 degrees in an adult patient: a uro-radiological case report

Severe penile torsion of 180 degrees in an adult patient: a uro-radiological case report

N-(1-Phenylethyl)aziridine-2-carboxylate esters in the synthesis of biologically relevant compounds

Evaluation of Tamsulosin 0.4 mg versus 0.8 mg in management of lower urinary tract symptoms due to benign prostatic enlargement

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