Tandem Hydrogen‐Borrowing Dehydrogenative Coupling and Hydrodefluorination

Abstract

Dehydrogenative coupling (DC) is an attractive approach to constructing new C‐N bonds using alcohols as electrophiles. In ‘hydrogen‐borrowing’ variants of DC, the H<sub>2</sub> liberated can be used to re‐hydrogenate unsaturated intermediates to produce saturated products. Here, we show how so‐generated H<sub>2</sub> can also be used to replace fluorine atoms with hydrogens in CF<sub>3</sub> groups in a tandem dehydrogenative coupling/hydrodefluorination process.