Tangential Neuronal Migration Controls Axon Guidance: A Role for Neuregulin-1 in Thalamocortical Axon Navigation

López‐Bendito, Guillermina; Cautinat, Aline; Sánchez, Juan Antonio; Bielle, Franck; Flames, Nuria; Garratt, Alistair N.; Talmage, David A.; Role, Lorna W.; Charnay, Patrick; Marı́n, Oscar; Garel, Sonia

doi:10.1016/j.cell.2006.01.042

Cited by 340 publications

(371 citation statements)

References 51 publications

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“…Neuregulin 1-ErbB signaling plays multiple critical roles in proper development of the neocortex, guiding both the tangential migration of MGE-derived GABAergic interneurons (Flames et al, 2004) and proper navigation of axonal projections from the dorsal thalamus into the cortex (Lopez-Bendito et al, 2006). Whether neuregulin also guides the migration and/or axon projections of forebrain cholinergic neurons is not known.…”

Section: B Potential Role Of Neuregulinmentioning

confidence: 99%

“…Neuregulin 1 has been linked to schizophrenia in multiple populations, and disease-associated changes in the relative expression of different neuregulin 1 isoforms is seen in the DFPLC and hippocampus. Neuregulin 1 isoforms play important roles in neurodevelopment, in particular in the patterning of the neocortex (Flames et al, 2004;Lopez-Bendito et al, 2006). At present, these latter roles for neuregulin 1 have focused on tangential migration of cortical interneurons and axonal projections from the dorsal thalamus to the neocortex.…”

Section: B Potential Role Of Neuregulinmentioning

confidence: 99%

“…Subsequent to this early birth and migration from the MGE, 1-2 weeks pass before these neurons undergo maturation into cholinergic neurons (Aznavour et al, 2005;Berger-Sweeney, 2003;Mechawar and Descarries, 2001). This delay allows time for other populations of predominantly GABAergic neurons to emerge from the MGE and LGE and occupy their appropriate positions throughout the striatum and cortex for radial population of the neocortex with pyramidal cells and for the proper targeting of axons from the dorsal thalamus to project through the striatal region to innervate cortical structures (Flames et al, 2004;Lopez-Bendito et al, 2006;van Vulpen and van der Kooy, 1998). Some investigators propose that during this period the presumptive cholinergic neurons provide instructive signals that guide the targeting and differentiation of later born striatal populations (Berger-Sweeney, 2003;Hohmann, 2003;Hohmann and BergerSweeney, 1998).…”

Section: A Development Of Cholinergic Systemsmentioning

confidence: 99%

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Cholinergic Circuits and Signaling in the Pathophysiology of Schizophrenia

Berman

Talmage

Role

2007

International Review of Neurobiology

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Central cholinergic signaling has long been associated with aspects of memory, motivation, and mood, each affected functions in neuropsychiatric disorders such as schizophrenia. In this chapter, we review evidence related to the core hypothesis that dysregulation of central cholinergic signaling contributes to the pathophysiology of schizophrenia. Although central cholinergic circuits are resistant to simplification-particularly when one tries to parse the contributions of various classes of cholinergic receptors to disease related phenomena-the potential role of ACh signaling in Schizophrenia pathophysiology deserves careful consideration for prospective therapeutics. The established role of cholinergic circuits in attentional tuning is considered along with recent work on how the patterning of cholinergic activity may modulate corticostriatal circuits affected in schizophrenia.

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Section: B Potential Role Of Neuregulinmentioning

confidence: 99%

Section: B Potential Role Of Neuregulinmentioning

confidence: 99%

Section: A Development Of Cholinergic Systemsmentioning

confidence: 99%

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Cholinergic Circuits and Signaling in the Pathophysiology of Schizophrenia

Berman

Talmage

Role

2007

International Review of Neurobiology

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“…Furthermore, we show that ER␤ modulates expression of epidermal growth factor receptor (EGFR). Because EGFR has been demonstrated to promote radial migration in dorsal cortex, influencing neurons settling predominantly in deep layers of the cortical plate and the marginal zone (26,27), this may be a mechanism through which ER␤ might regulate migration of cortical neurons of the upper laminae during prenatal life. …”

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confidence: 99%

Estrogen receptor β expression in the embryonic brain regulates development of calretinin-immunoreactive GABAergic interneurons

Fan

Warner

Gustafsson

2006

Proc. Natl. Acad. Sci. U.S.A.

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Our previous studies with estrogen receptor ␤ knockout (ER␤ ؊/؊ ) mice demonstrated that ER␤ is necessary for embryonic development of the brain as early as embryonic day 14.5 (E14.5) and is involved in neuronal migration. Such early effects of ER were unexpected because estradiol synthesis and action in the brain occur at E18.5. In the present study, we examined the distribution of ER␤ in the developing brain and identified a population of ER␤-regulated interneurons. ER␤ appears in the brain at E12.5, mainly localized in the wall of the midbrain, neuromere, hypothalamus, thalamus, and basal plate of pons. At E15.5 and E16.5, ER␤ expression increased in the hypothalamus, thalamus, and midbrain and appeared in the limbic forebrain. At E18.5, ER␤ expression was strongly expressed throughout the brain, including the cerebellum and striatum, whereas there were very few positive cells in the ventricular region. In the paraventricular thalamic nucleus and parafascicular nucleus, most of the calretinin-immunopositive interneurons expressed ER␤. In ER␤ ؊/؊ mice, calretinin expression was markedly lower than in WT mice in the hippocampus, thalamus, and amygdala both at E16.5 and at E18.5. Epidermal growth factor receptor expression was lower in the cortex of ER␤ ؊/؊ than in WT mice at E15.5 and, unlike WT mice, was absent from the superficial marginal zone. These findings suggest that ER␤ in the embryonic brain is necessary for the development of calretininimmunoreactive GABAergic interneurons and for neuronal migration in the cortex through modulating epidermal growth factor receptor expression at middle and later embryonic stages.cortex ͉ EGF receptor ͉ striatum ͉ thalamus E strogen is important during brain development, influencing the maturation of neural systems and affecting the sexual differentiation of brain structures and functions (1, 2). Sexual differentiation in the brain occurs in male rodents at day 18.5 when aromatase is induced in the brain and catalyses the synthesis of estradiol from testosterone secreted from the embryonic testis. At this time, estrogen imprints the neuroendocrine control of gonadal function, reproductive behavior, and the sexual differences in the secretion of growth hormone.Estrogen actions now are recognized to occur via two distinct estrogen receptors (ER), ER␣ and ER␤, that reside in cell nuclei (3, 4). In the brain, ER␣ plays a critical role in regulating reproductive neuroendocrine function, whereas ER␤ may be more important in regulating nonreproductive functions (5-8).In ER␣ knockout mice, no gross brain abnormalities have been reported, whereas ER␤ plays a prominent role during embryogenesis and there are significant morphological abnormalities in the embryonic brains of ER␤ knockout (ER␤ Ϫ/Ϫ ) mice (9). Studies have revealed that ER␤ also is expressed in fetal human brain and may mediate effects of estrogen in the developing nervous system (10). Lemmen et al. (11) reported that ER␤ mRNA is detectable in brains of mouse embryo at embryonic day 10.5 (E10.5), but there is no i...

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“…Comment est apparu ce changement extrinsèque qui a sans doute favorisé le succès évolutif du néocortex, reste largement inconnu. En utilisant le modèle expérimental de l'embryon de souris, notre équipe avait précédem-ment montré que le guidage interne des axones thalamiques requiert, en plus des activités et molécules déjà impliquées ([1] et pour revue [2]), la formation d'un corridor permissif construit par une migration de neurones dénommés de ce fait « cellules du corridor » ( Figure 1C) [3]. Cette découverte ouvrait la perspective que les cellules « guides » du corridor puissent être impliquées dans la différence de trajectoire des axones thalamiques entre les mammifères et les autres vertébrés.…”

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