Tangeretin, a citrus pentamethoxyflavone, exerts cytostatic effect via p53/p21 up-regulation and suppresses metastasis in 7,12-dimethylbenz(α)anthracene-induced rat mammary carcinoma

Arivazhagan, Lakshmi; Pillai, Subramanian Sorimuthu

doi:10.1016/j.jnutbio.2014.06.007

Cited by 66 publications

(31 citation statements)

References 47 publications

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“…It has been suggested that flavonoids-rich diet has an adverse effect on the proliferation of cancer cells [94,95].Various mechanisms have been proposed to explain the anti-proliferative activity of flavonoids, for example, it has been proposed that the anti-proliferative effects of flavonoids are mainly mediated by the inhibition on several kinases and kinase inhibitors involved in cellcycle arrest and apoptosis [85]. Cyclin-dependent kinases (CDKs) have been recognized as key regulators of cell cycle progression.…”

Section: Anti-proliferationmentioning

confidence: 99%

“…Nobiletin was found to act as an anti-carcinogenic compound through anti-proliferative activity, induction of apoptosis and cell cycle deregulation [93]. It was reported that tangeretin suppressed breast cancer proliferation by up-regulating p53/p21 proteins and inducing G1/S phase cell cycle arrest [94].…”

Section: Anti-proliferationmentioning

confidence: 99%

“…Ishiwa et al [106] reported that the flavonoids isolated from Citrus depressa Hayata including tangeretin, 6-demethoxytangeretin, nobiletin, 5-demethylnobiletin, 6-demethoxynobiletin, and sinensetin suppressed the interleukin 1 (IL-1) induced production of proMMP-9/progelatinase B in rabbit synovial cells in a dose dependent manner, among these flavonoids, nobiletin is most effectively in suppressing proMMP-9 production along with the decrease in its mRNA. Arivazhagan L et al [94] reported that tangeretin treatment significantly suppressed matrix metalloproteinase (MMP)-2, MMP-9 in a DMBA-induced animal models. Lee et al [107] found that naringin extracted from Citrus fruits including grapefruit suppressed the upregulation of MMP-9 and repressed the PI3K/AKT/mTOR signaling pathway.…”

Section: Anti-metastasismentioning

confidence: 99%

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<i>Citrus</i> Flavonoids and Human Cancers

Ke¹,

Pan²,

Xu³

et al. 2015

JFNR

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Nowadays cancers pose a great threat to the health of human beings. Based on studies on the flavonoids and other bioactive compounds of Citrus fruits in current literature, it was widely suggested that the consumption of Citrus fruits is beneficial to the prevention and treatment of human chronic diseases including cancers. In the past decades, the study concerning Citrus flavonoids has covered various areas including the type, content and distribution of flavonoids in fruits; their variation between wild and cultivated genotypes; their antioxidant, antiinflammation, anti-aging, antimicrobial and anticarcinogenic activities. To enlighten future Citrus germplasm study, this review introduces briefly the functions of main types of Citrus flavonoids, including antioxidant, antiinflammation and anti-aging activities, and their relationships to human cancers. Most importantly, the mechanisms of action by which Citrus flavonoids play their roles in human cancer prevention and treatment were summarized.

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Section: Anti-proliferationmentioning

confidence: 99%

Section: Anti-proliferationmentioning

confidence: 99%

Section: Anti-metastasismentioning

confidence: 99%

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<i>Citrus</i> Flavonoids and Human Cancers

Ke¹,

Pan²,

Xu³

et al. 2015

JFNR

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“…Orally administered Tangeretin, a citrus pentamethoxyflavone remarkably inhibited metastasis in chemically induced rat mammary carcinoma model (Arivazhagan and Sorimuthu Pillai, 2014).…”

Section: In Vivo Studiesmentioning

confidence: 96%

“…Metastasis was inhibited in chemically induced cancer model via inhibition of MMP2 and MMP9 by Tangeretin (Arivazhagan and Sorimuthu Pillai, 2014). Migratory potential of TSGH-8301 bladder cancer cells was reduced upon Naringenin mediated targeting of MMP2 (Liao et al, 2014).…”

Section: Mmpmentioning

confidence: 99%

Citrus Fruits and their Bioactive Ingredients: Leading Four Horsemen from Front

Farooqı¹,

Wang²,

Hasnain³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Cancer is a multifaceted and genomically complex disease and rapidly accumulating high impact research is deepening our understanding related to the mechanisms underlying cancer development, progression and resistance to therapeutics. Increasingly it is being realized that genetic/epigenetic mutations, inactivation of tumor suppressor genes, overexpression of oncogenes, deregulation of intracellular signaling cascades and loss of apoptosis are some of the extensively studied aspects. Confluence of information suggested that rapidly developing resistance to therapeutics is adding another layer of complexity and overwhelmingly increasing preclinical studies are identifying different natural agents with efficacy and minimal off-target effects. We partition this multi-component review into citrus fruits and their bioactive ingredients mediating rebalancing of pro-and anti-apoptotic proteins to induce apoptosis in resistant cancer cells. We also discuss how oncogenic protein networks are targeted in cancer cells and how these findings may be verified in preclinical studies.

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