Tangeretin prevents obesity by modulating systemic inflammation, fat browning, and gut microbiota in high-fat diet-induced obese C57BL/6 mice

Chen, Qiyang; Wang, Dan; Gu, Yan; Jiang, Zixiao; Zhou, Zhiqin

doi:10.1016/j.jnutbio.2022.108943

Cited by 22 publications

(11 citation statements)

References 67 publications

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“…This process allows brown adipocytes to actively oxidize substrates to produce heat [8]. Numerous studies reported that BAT-mediated thermogenesis can protect against obesity by promoting energy expenditure [9][10][11]. Thus, activation of the thermogenesis function of BAT is an expected way to treat obesity.…”

Section: Introductionmentioning

confidence: 99%

Erchen Decoction Ameliorates the Metabolic Abnormalities of High-Fat Diet-Fed Rats

Cheng

Zhang

et al. 2022

Computational and Mathematical Methods in Medicine

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Objective. Brown adipose tissue (BAT) dissipates chemical energy to protect against obesity. In the present study, we aimed to determine the effects of Erchen decoction on the lipolysis and thermogenesis function of BAT in high-fat diet-fed rats. Methods. Sprague-Dawley rats were randomly divided into four groups, which were fed a control diet (C) or a high-fat diet (HF), and the latter was administered with high and low doses of Erchen decoction by gavage once a day, for 12 weeks. Body weight, the serum lipid profile, serum glucose, and insulin levels of the rats were evaluated. In addition, the phosphorylation and protein and mRNA expression of AMP-activated protein kinase (AMPK), adipose triglyceride lipase (ATGL), peroxisome proliferator-activated receptor γ coactivator- (PGC-) 1α, and uncoupling protein 1 (UCP-1) in BAT were measured by immunoblotting and RT-PCR. Results. Erchen decoction administration decreased body weight gain and ameliorated the abnormal lipid profile and insulin resistance index of the high-fat diet-fed rats. In addition, the expression of p-AMPK and ATGL in the BAT was significantly increased by Erchen decoction. Erchen decoction also increased the protein and mRNA expression of PGC-1α and UCP-1 in BAT. Conclusion. Erchen decoction ameliorates the metabolic abnormalities of high-fat diet-fed rats, at least in part via activation of lipolysis and thermogenesis in BAT.

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Section: Introductionmentioning

confidence: 99%

Erchen Decoction Ameliorates the Metabolic Abnormalities of High-Fat Diet-Fed Rats

Cheng

Zhang

et al. 2022

Computational and Mathematical Methods in Medicine

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“…HFD-induced obesity has been demonstrated to be associated with gut microbiota dysbiosis, as manifested by reduced gut microbiota diversity and altered composition of gut microbiota. − Obese objects received a significantly higher ratio of Firmicutes to Bacteroidetes (F/B), indicating that they might get more energy from diets. A lower abundance of Bacteroidetes was associated with overweight. , TSs consumption could modulate gut microbiota diversity and F/B, especially an increase of Bacteroidetes, revealing protective features. Actinobacteria, another major phylum, was found to be increased in obese individuals.…”

Section: Discussionmentioning

confidence: 91%

“…A lower abundance of Bacteroidetes was associated with overweight. 37,38 TSs consumption could modulate gut microbiota diversity and F/B, especially an increase of Bacteroidetes, revealing protective features. Actinobacteria, another major phylum, was found to be increased in obese individuals.…”

Section: Discussionmentioning

confidence: 98%

Total Sesquiterpenoids of Loquat Leaves Alleviated High-Fat Diet-Induced Obesity by Targeting Fecal Metabolic Profiling and Gut Microbiota Composition

Jian

Zhou

Chen

et al. 2022

J. Agric. Food Chem.

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In the present study, we demonstrated that whether the gut microbiota and related metabolites contribute to the therapeutic effect of total sesquiterpenoids (TSs) from loquat leaves on obesity. A 4-week high fat diet was used to induce obesity which was then treated with TSs for another 4 weeks. TSs remarkedly reduced the weight of body and white adipose and the levels of total cholesterol (TC) and triglyceride (TG) in serum. We also found that TSs restored the diversity and richness of gut microbiota. In addition, TSs administration affected the relative abundance of seven key genera. Meanwhile, TSs were determined to affect the metabolism of the host through detecting the metabolites in feces. By applying KEGG and the correlation analysis with gut microbiota, 10 differential metabolites were identified to be the key. The results in this work proved that TSs inhibited obesity by remodeling gut microbiota and related metabolites.

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“…Preclinical studies have shown that nutraceuticals capable of modulating the microbiota profile can affect thermogenic fat activation. Obese mice treated with the flavonoid tangeretin displayed a reduction in body weight, liver steatosis and improved glucose metabolism [ 156 ]. Of note, tangeretin treatment was able to alter the gut microbiota composition and stimulate BAT activity, counteracting the dysbiosis and reducing the ratio of Firmicutes to Bacteroidetes [ 156 ].…”

Section: Nutraceuticals and Microbiotamentioning

confidence: 99%

“…Obese mice treated with the flavonoid tangeretin displayed a reduction in body weight, liver steatosis and improved glucose metabolism [ 156 ]. Of note, tangeretin treatment was able to alter the gut microbiota composition and stimulate BAT activity, counteracting the dysbiosis and reducing the ratio of Firmicutes to Bacteroidetes [ 156 ]. In another study, mice fed a HFD supplemented with the natural polymethoxyflavone nobiletin showed reduced obesity and induction of WAT browning, along with a composition shift in the gut microbiota, which displayed an increase in the abundance of Bacteroidetes and in the ratio of Bacteroidetes to Firmicutes [ 157 ].…”

Section: Nutraceuticals and Microbiotamentioning

confidence: 99%

Nutraceuticals in Brown Adipose Tissue Activation

Armani

Feraco

Camajani

et al. 2022

Cells

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Obesity and its associated comorbidities have become pandemic, and challenge the global healthcare system. Lifestyle changes, nutritional interventions and phamaceuticals should be differently combined in a personalized strategy to tackle such a public health burden. Altered brown adipose tissue (BAT) function contributes to the pathophysiology of obesity and glucose metabolism dysfunctions. BAT thermogenic activity burns glucose and fatty acids to produce heat through uncoupled respiration, and can dissipate the excessive calorie intake, reduce glycemia and circulate fatty acids released from white adipose tissue. Thus, BAT activity is expected to contribute to whole body energy homeostasis and protect against obesity, diabetes and alterations in lipid profile. To date, pharmacological therapies aimed at activating brown fat have failed in clinical trials, due to cardiovascular side effects or scarce efficacy. On the other hand, several studies have identified plant-derived chemical compounds capable of stimulating BAT thermogenesis in animal models, suggesting the translational applications of dietary supplements to fight adipose tissue dysfunctions. This review describes several nutraceuticals with thermogenic properties and provides indications, at a molecular level, of the regulation of the adipocyte thermogenesis by the mentioned phytochemicals.

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Tangeretin prevents obesity by modulating systemic inflammation, fat browning, and gut microbiota in high-fat diet-induced obese C57BL/6 mice

Cited by 22 publications

References 67 publications

Erchen Decoction Ameliorates the Metabolic Abnormalities of High-Fat Diet-Fed Rats

Erchen Decoction Ameliorates the Metabolic Abnormalities of High-Fat Diet-Fed Rats

Total Sesquiterpenoids of Loquat Leaves Alleviated High-Fat Diet-Induced Obesity by Targeting Fecal Metabolic Profiling and Gut Microbiota Composition

Nutraceuticals in Brown Adipose Tissue Activation

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