Tangshen Formula Improves Diabetes-Associated Myocardial Fibrosis by Inhibiting TGF-β/Smads and Wnt/β-Catenin Pathways

Hu, Lin; Wang, Yuyang; Wan, Yuzhou; Zhao, Tingting; Li, Ping

doi:10.3389/fmed.2021.732042

Cited by 8 publications

(7 citation statements)

References 36 publications

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“…This may alleviate myocardial fibrosis in KKAy mouse models by inhibiting TGF-β/Smad and Wnt/β-catenin signaling pathways. These findings may increase our knowledge regarding effect of TSF in diabetes (L. Hu, Wang, et al, 2021).…”

Section: Role Of Wnt In Type 2 Diabetesmentioning

confidence: 62%

Wnt signaling pathway: A comprehensive review

Hayat

Manzoor

Hussain

2022

Cell Biology International

153

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Wnt signaling is an evolutionary cell‐to‐cell coordination mechanism and it is highly critical for a variety of physiological processes of an organism's body, including stem cell regeneration, proliferation, division, migration, polarity of a cell, determining fate of the cell and specification of neural crest, neural symmetry and morphogenesis. Wnts are extracellular secreted glycol proteins, consisted of a family of 19 human proteins that represent the complex nature of the regulatory structure and physiological efficiency of signaling. Moreover, a Wnt/β‐catenin‐dependent pathway and the β‐catenin‐independent pathway that is further classified into the Planar Cell Polarity and Wnt/Ca2+ pathways have been established as key signaling nodes downstream of the frizzled (Fz/Fzd) receptor, and these nodes are extensively analyzed at biochemical and molecular levels. Genetic and epigenetic activities that ultimately characterize the pathway and its subsequent responses contribute to Wnt‐β‐catenin signaling pathway hypo or hyper‐activation and is associated with the variety of human disorders progression most significantly cancers. Recognizing how this mechanism operates is crucial to the advancement of cancer prevention therapies or regenerative medicine methods.

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Section: Role Of Wnt In Type 2 Diabetesmentioning

confidence: 62%

Wnt signaling pathway: A comprehensive review

Hayat

Manzoor

Hussain

2022

Cell Biology International

153

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“…Smad2/3 and Smad4 are downstream factors of the TGF-β/Smads signal pathway, followed by the stimulation of HG or TGF-β, Smad4 will bind to the phosphorylated Smad2/3 to form a complex and then translocated to the nucleus as transcriptional factors to promote the expression of ECM and inhibition of TGF-β/Smads signal pathway could alleviate excess ECM expression and improve DN (Hu et al. 2021 ). Consistent with these studies, our work indicated that kirenol could inhibit the TGF-β/Smads signal pathway and then alleviate ECM accumulation both in DN animal and cell models.…”

Section: Discussionmentioning

confidence: 99%

Kirenol alleviates diabetic nephropathy via regulating TGF-β/Smads and the NF-κB signal pathway

Zhang

Yang

et al. 2022

Pharmaceutical Biology

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Context Kirenol possesses anti-inflammatory, antifibrotic and anti-arthritic effects. However, its reno-protective effects against diabetic nephropathy (DN) have not been evaluated. Objective This study explores the reno-protective effects of kirenol against DN and clarifies the potential mechanisms. Materials and methods The mesangial cells were treated with 20 µM kirenol and 10 ng/mL human recombinant TGF-β1 or 30 mM glucose for 24 h. Then the cells were harvested to assay the expression of the target genes or proteins. Thirty C57BL/6J male mice were given high-fat diet with streptozotocin injection to induce diabetes and then were randomized into three groups ( n = 10): vehicle administration (DM group), 2 mg/kg kirenol (DM + kirenol group) and 200 mg/kg metformin (Met group) for 3 months, orally. A healthy group (Con, n = 10) was included as the control. Results Compared to the DM group, kirenol treatment decreased the phosphorylation of Smad2/3 and NF-κB (0.64- and 0.43-fold) as well as the accumulation of FN and Col IV (0.58- and 0.35-fold); moreover, the expression of IκBα was restored to normal level by kirenol treatment both in vivo and in vitro . After kirenol treatment, IL-6 expression was decreased 0.35- and 0.57-fold, and TNF-α expression was decreased 0.34- and 0.46-fold, in vitro and in vivo , respectively. Furthermore, kirenol alleviated the glomerular basement membrane thickness and foot process fusion. Discussion and conclusions Kirenol could alleviate DN by downregulating the TGF-β/Smads and the NF-κB signal pathway. Our study provides a potential mechanism for the treatment of DN with kirenol.

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“…[110] The Tangshen formula has significant therapeutic effects on multiple organ damage, [111] including the treatment of fatty liver, [109] improvement of gastrointestinal dynamics, [112] and reduction of myocardial fibrosis while fighting renal fibrosis. [113]…”

Section: Advantages and Advances In Mechanism Ofmentioning

confidence: 99%

Top 10 academic progress on traditional Chinese medicine in 2022

2023

Sci Tradit Chin Med

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Background To implement the spirit of the 20th National Congress of the Communist Party of China and the Opinions on Promoting the Inheritance, Innovation, and Development of Traditional Chinese Medicine (TCM), regularly summarize the research results of TCM, present the academic progress on TCM dynamically, and fully leverage the academic leadership of academic groups, the China Association of Chinese Medicine organized the selection of the top 10 academic progress on TCM in 2022. The selection process adhered to 4 orientations, eliminated any biases, highlighted the solutions to clinical problems, answered scientific questions, and led the industry’s development. It reflected an exploratory and forward-looking approach, emphasizing innovation and breakthroughs. The selection focused on new laws, new discoveries, new methods, new products, and new theories in the field of basic research and applied basic research in TCM. Through a process of dynamic collection, preliminary examination, review, and final judgment, the top 10 academic progress of TCM in 2022 were determined.

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Tangshen Formula Improves Diabetes-Associated Myocardial Fibrosis by Inhibiting TGF-β/Smads and Wnt/β-Catenin Pathways

Cited by 8 publications

References 36 publications

Wnt signaling pathway: A comprehensive review

Wnt signaling pathway: A comprehensive review

Kirenol alleviates diabetic nephropathy via regulating TGF-β/Smads and the NF-κB signal pathway

Top 10 academic progress on traditional Chinese medicine in 2022

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