Tannase‐Converted Green Tea Extract with High (−)‐Epicatechin Inhibits Skeletal Muscle Mass in Aged Mice

Hong, Ki‐Bae; Lee, Hee-Seok; Kim, Dong Hyeon; Moon, Joo Myung; Park, Yooheon

doi:10.1155/2020/4319398

Cited by 10 publications

(16 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results of in vitro experiments showed the beneficial effects of epicatechin on muscle wasting and muscle function. Additionally, epicatechin increased the mRNA expression of MyoD, superoxide dismutase (SOD), and catalase in the biceps femoris muscle and decreased the expression of FoxO3, myostatin, and MuRF1 in the soleus muscle (Hong et al, 2020). Si et al (2019) observed that epicatechin increased the survival rate of aged mice and delayed the degeneration of skeletal muscle.…”

Section: Epicatechinmentioning

confidence: 99%

Flavonoids: nutraceutical potential for counteracting muscle atrophy

Kim

Hwang

2020

Food Sci Biotechnol

View full text Add to dashboard Cite

Skeletal muscle plays a vital role in the conversion of chemical energy into physical force. Muscle atrophy, characterized by a reduction in muscle mass, is a symptom of chronic disease (cachexia), aging (sarcopenia), and muscle disuse (inactivity). To date, several trials have been conducted to prevent and inhibit muscle atrophy development; however, few interventions are currently available for muscle atrophy. Recently, food ingredients, plant extracts, and phytochemicals have received attention as treatment sources to prevent muscle wasting. Flavonoids are bioactive polyphenol compounds found in foods and plants. They possess diverse biological activities, including anti-obesity, anti-diabetes, anti-cancer, anti-oxidation, and anti-inflammation. The effects of flavonoids on muscle atrophy have been investigated by monitoring molecular mechanisms involved in protein turnover, mitochondrial activity, and myogenesis. This review summarizes the reported effects of flavonoids on sarcopenia, cachexia, and disuse muscle atrophy, thus, providing an insight into the understanding of the associated molecular mechanisms.

show abstract

Section: Epicatechinmentioning

confidence: 99%

Flavonoids: nutraceutical potential for counteracting muscle atrophy

Kim

Hwang

2020

Food Sci Biotechnol

View full text Add to dashboard Cite

show abstract

“…The findings that GTE supplementation enhances total antioxidant potential (i.e., GSH-Px, SOD, CAT) and lowers carbonylated protein levels in skeletal muscle are consistent in a variety of rodent models including BALB/c mice, female Sprague-Dawley rats, and male Kunming mice [101][102][103]. Interestingly, in male ICR mice, tannase-converted GTE (80 µM) with greater antioxidant capacity increased antioxidant enzyme SOD and CAT content [104].…”

Section: Rodent Studiesmentioning

confidence: 62%

Impacts of Green Tea on Joint and Skeletal Muscle Health: Prospects of Translational Nutrition

et al. 2020

View full text Add to dashboard Cite

Osteoarthritis and sarcopenia are two major joint and skeletal muscle diseases prevalent during aging. Osteoarthritis is a multifactorial progressive degenerative and inflammatory disorder of articular cartilage. Cartilage protection and pain management are the two most important strategies in the management of osteoarthritis. Sarcopenia, a condition of loss of muscle mass and strength, is associated with impaired neuromuscular innervation, the transition of skeletal muscle fiber type, and reduced muscle regenerative capacity. Management of sarcopenia requires addressing both skeletal muscle quantity and quality. Emerging evidence suggests that green tea catechins play an important role in maintaining healthy joints and skeletal muscle. This review covers (i) the prevalence and etiology of osteoarthritis and sarcopenia, such as excessive inflammation and oxidative stress, mitochondrial dysfunction, and reduced autophagy; (ii) the effects of green tea catechins on joint health by downregulating inflammatory signaling mediators, upregulating anabolic mediators, and modulating miRNAs expression, resulting in reduced chondrocyte death, collagen degradation, and cartilage protection; (iii) the effects of green tea catechins on skeletal muscle health via maintaining a dynamic balance between protein synthesis and degradation and boosting the synthesis of mitochondrial energy metabolism, resulting in favorable muscle homeostasis and mitigation of muscle atrophy with aging; and (iv) the current study limitations and future research directions.

show abstract

“…These observations are consistent with previous results from our group showing that EC administration resulted in a significant increase in the expression of muscle differentiation genes, such as myoblast determination protein (MyoD) and myogenin genes in stressed C2C12 muscle cells [20]. The levels of factors related to muscle degradation or loss, such as forkhead box protein O3 (FOXO3), myostatin, muscle RING finger protein-1 (MuRF-1), and atrogin-1, were also significantly reduced by treatment with green tea extract with a high EC content in aged mice [21]. Additionally, treatment of antioxidant-rich plant extracts resulted in increased levels of the muscle growth and production factors p70 S6 kinase (pS6K) levels and mammalian target of rapamycin (mTOR), along with the levels of follistatin, which inhibits myostatin [41,52,53].…”

Section: Discussionmentioning

confidence: 99%

“…The use of tannase-treated green tea extract containing a high content of EC and GA has been reported to improve skeletal muscle recovery [20,21]. However, whether such beneficial effects occur in humans without added exercise is unknown.…”

Section: Introductionmentioning

confidence: 99%

(−)-Epicatechin-Enriched Extract from Camellia sinensis Improves Regulation of Muscle Mass and Function: Results from a Randomized Controlled Trial

et al. 2021

Self Cite

View full text Add to dashboard Cite

Loss of skeletal muscle mass and function with age represents an important source of frailty and functional decline in the elderly. Antioxidants from botanical extracts have been shown to enhance the development, mass, and strength of skeletal muscle by influencing age-related cellular and molecular processes. Tannase-treated green tea extract contains high levels of the antioxidants (−)-epicatechin (EC) and gallic acid that may have therapeutic benefits for age-related muscle decline. The aim of this study was to investigate the effect of tannase-treated green tea extract on various muscle-related parameters, without concomitant exercise, in a single-center, randomized, double-blind, placebo-controlled study. Administration of tannase-treated green tea extract (600 mg/day) for 12 weeks significantly increased isokinetic flexor muscle and handgrip strength in the treatment group compared with those in the placebo (control) group. In addition, the control group showed a significant decrease in arm muscle mass after 12 weeks, whereas no significant change was observed in the treatment group. Blood serum levels of follistatin, myostatin, high-sensitivity C-reactive protein (hs-CRP), interleukin (IL)-6, IL-8, insulin-like growth factor-1 (IGF-1), and cortisol were analyzed, and the decrease in myostatin resulting from the administration of tannase-treated green tea extract was found to be related to the change in muscle mass and strength. In summary, oral administration of tannase-treated green tea extract containing antioxidants without concomitant exercise can improve muscle mass and strength and may have therapeutic benefits in age-related muscle function decline.

show abstract

Tannase‐Converted Green Tea Extract with High (−)‐Epicatechin Inhibits Skeletal Muscle Mass in Aged Mice

Cited by 10 publications

References 38 publications

Flavonoids: nutraceutical potential for counteracting muscle atrophy

Flavonoids: nutraceutical potential for counteracting muscle atrophy

Impacts of Green Tea on Joint and Skeletal Muscle Health: Prospects of Translational Nutrition

(−)-Epicatechin-Enriched Extract from Camellia sinensis Improves Regulation of Muscle Mass and Function: Results from a Randomized Controlled Trial

Contact Info

Product

Resources

About