Tannic acid-induced apoptosis and -enhanced sensitivity to arsenic trioxide in human leukemia HL-60 cells

Chen, Kuo-Shuen; Hsiao, Yung-Chin; Kuo, Dong‐Yih; Chou, Ming-Chih; Chu, Shu‐Chen; Hsieh, Yih‐Shou; Lin, Tseng‐Hsi

doi:10.1016/j.leukres.2008.08.006

Cited by 50 publications

(36 citation statements)

References 39 publications

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“…Chen et al showed pro-apoptotic activity of TA on the cells of the HL-60 line depending on the time of exposition and TA dose. [63] The authors noticed 50% reduction in cell viability after 24 h incubation at a TA concentration equal to 17 mM. Experiments described in our publication were performed after subsequent purification steps aimed at removing the postsynthesis remains (including TA).…”

Section: Discussionmentioning

confidence: 88%

Gold nanoparticles and ions – friends or foes? As they are seen by human cells U-937 and HL-60

Barbasz

Oćwieja

2015

Journal of Experimental Nanoscience

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Gold nanoparticles (AuN) are one of the most investigated nanomaterials, finding numerous applications from medicine to industry. AuN were obtained by reduction of gold salts using tannic acid as a reducing agent. To detach the impact of AuN onto cells of two lines human monocytic cells (U-937) and human promyelocytic leukaemia cells (HL-60), the effects of postreaction residues (of effluent from sol cleaning) and gold ions were also examined. It was demonstrated that resistance of cells to the toxic action of AuN is dependent not only on incubation time and dosage, but also on stages of cell differentiation. It was found that after incubation of promonocytes U-937 with 25 ppm AuN, the cell viability decreased by 25% and of macrophages by 50%. Differentiated cells U-937 showed a significantly lower resistance than the not-differentiated cells. For HL-60 cells, regardless of differentiation, cell viability decreased by approximately 20% after treatment with 25 ppm AuN sol. It was noticed that U-937 exhibited higher vulnerability to AuN than HL-60 cells. It was proved that AuN induced over a 15-fold increase in nitric oxide and a decrease of intracellular glutathione levels indicating the inflammatory response of cells. Even though gold ions did not show a significant effect on cell viability, they caused fivefold increase of nitric oxide level. The results show a higher cytotoxicity of AuN than gold ions. An overall picture of the interaction of AuN with human cells of first defence line was obtained. The results indicate that AuN may cause changes in the response of phagocytes in inflammatory conditions.

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Section: Discussionmentioning

confidence: 88%

Gold nanoparticles and ions – friends or foes? As they are seen by human cells U-937 and HL-60

Barbasz

Oćwieja

2015

Journal of Experimental Nanoscience

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“…Day zero on the graph is day 7 after tumor injection. *Denotes significant differences (p < 0.05) with respect to control (days [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19], † significant with respect to prevention group at day 14. (B) Real time pCR analysis of TNFα, IL-1α and IL6 in the tumor tissue sections of control and GT-treated mice.…”

Section: Discussionmentioning

confidence: 99%

“…3 GT inhibited the proliferation of various tumor cells, including colorectal carcinoma, prostate cancer and acute myeloid leukemia, without being toxic to normal cells. [4][5][6][7][8] In animal models, GT suppressed the biochemical and biological effects of the potent tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) in mouse epidermis in vivo, and reduced the formation of 1,2-dimethylhydrazine (DMH)-induced colonic aberrant crypt foci (ACF) and tumors in Balb/c mice. 9,10 We have recently shown that GT inhibits HCT-116…”

Section: Introductionmentioning

confidence: 99%

Gallotannin inhibits NFĸB signaling and growth of human colon cancer xenografts

Al-Halabi¹,

Chedid²,

Merhi³

et al. 2011

Cancer Biology & Therapy

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“…Effects of tannic acid as an anti-cancer agent have not been fully explored. So far one study has shown its apoptotic effects on HL60 cells were both dose and time-dependent but has no effect on the viability of normal peripheral blood cells [23]. Concentrations of tannic acid used in this study were between 0 -25 µM with an IC-50 value of around 15 -20 µM.…”

Section: Discussionmentioning

confidence: 72%

Identifying Combinatorial Growth Inhibitory Effects of Various Plant Extracts on Leukemia Cells through Systematic Experimental Design

Cheong¹,

Htay.²,

Tan³

et al. 2012

AJPS

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Plant extracts are widely studied for their anti-cancer and cancer preventive effects. In this study, we compared the leukemia growth inhibition effects of seven different plant extracts, theaflavin, epigallocatechin gallate (EGCG), epicathechin (EC), apigenin, quercetin, chrysin and tannic acid, in vitro using the K562 erythroleukemia cell line and application of the design of experiments (DoE) methodology. Our systematic approach enabled us to isolate the main factor contribution, two-factor interactions and produced interaction relationships and/or models to describe growth inhibitory effects of different plant extracts when they are used in combination. The results identified tannic acid as the most significant inhibitor in this group and had synergistic effects with EGCG at specific concentrations. The fitted model of their combined effects showed that the most potent combination is at low concentrations of tannic acid (10 -20 µM) and high concentrations of EGCG (80 -100 µM). We further showed that tannic acid induced both growth inhibition and apoptosis in K562 cells in ranges between 10 -100 µM. The polyphenol caused cell cycle arrest at G2-phase under the higher concentrations. In summary, use of DoE techniques effectively identified the most prominent inducer in this group of plant bioactive compounds and produced combinatorial bioactivity of various polyphenols and flavonoids over the entire range of concentrations under study. This study exemplifies the usefulness of DoE and serves as a guide in its utility for in vitro assessment of bioactivity in plant constituents.

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Tannic acid-induced apoptosis and -enhanced sensitivity to arsenic trioxide in human leukemia HL-60 cells

Cited by 50 publications

References 39 publications

Gold nanoparticles and ions – friends or foes? As they are seen by human cells U-937 and HL-60

Gold nanoparticles and ions – friends or foes? As they are seen by human cells U-937 and HL-60

Gallotannin inhibits NFĸB signaling and growth of human colon cancer xenografts

Identifying Combinatorial Growth Inhibitory Effects of Various Plant Extracts on Leukemia Cells through Systematic Experimental Design

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