Tannic acid-inspired, self-healing, and dual stimuli responsive dynamic hydrogel with potent antibacterial and anti-oxidative properties

Shi, Wen; Kong, Yunfan; Su, Yajuan; Kuss, Mitchell; Jiang, Xiping; Li, Xiaowei; Xie, Jingwei; Duan, Bin

doi:10.1039/d1tb00156f

Cited by 92 publications

(45 citation statements)

References 67 publications

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“…Tannic acid, a natural polyphenol, is commonly found in green and black teas as well as nuts, fruits, and vegetables [ 124 ]. Emerging evidence indicates that tannic acid possesses multiple biological activities such as antioxidative, anti-inflammatory, antiviral, and antiapoptotic effects [ 125 – 127 ]. In addition, tannic acid exhibits neuroprotective effects as shown by the improvement of behavioral deficits and the inhibition of neurodegeneration [ 128 ].…”

Section: The Potential Therapy Of Phytochemicals As Nrf2 Activators I...mentioning

confidence: 99%

Targeting Nrf2-Mediated Oxidative Stress Response in Traumatic Brain Injury: Therapeutic Perspectives of Phytochemicals

Yong

Pan

et al. 2022

Oxidative Medicine and Cellular Longevity

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Traumatic brain injury (TBI), known as mechanical damage to the brain, impairs the normal function of the brain seriously. Its clinical symptoms manifest as behavioral impairment, cognitive decline, communication difficulties, etc. The pathophysiological mechanisms of TBI are complex and involve inflammatory response, oxidative stress, mitochondrial dysfunction, blood-brain barrier (BBB) disruption, and so on. Among them, oxidative stress, one of the important mechanisms, occurs at the beginning and accompanies the whole process of TBI. Most importantly, excessive oxidative stress causes BBB disruption and brings injury to lipids, proteins, and DNA, leading to the generation of lipid peroxidation, damage of nuclear and mitochondrial DNA, neuronal apoptosis, and neuroinflammatory response. Transcription factor NF-E2 related factor 2 (Nrf2), a basic leucine zipper protein, plays an important role in the regulation of antioxidant proteins, such as oxygenase-1(HO-1), NAD(P)H Quinone Dehydrogenase 1 (NQO1), and glutathione peroxidase (GPx), to protect against oxidative stress, neuroinflammation, and neuronal apoptosis. Recently, emerging evidence indicated the knockout (KO) of Nrf2 aggravates the pathology of TBI, while the treatment of Nrf2 activators inhibits neuronal apoptosis and neuroinflammatory responses via reducing oxidative damage. Phytochemicals from fruits, vegetables, grains, and other medical herbs have been demonstrated to activate the Nrf2 signaling pathway and exert neuroprotective effects in TBI. In this review, we emphasized the contributive role of oxidative stress in the pathology of TBI and the protective mechanism of the Nrf2-mediated oxidative stress response for the treatment of TBI. In addition, we summarized the research advances of phytochemicals, including polyphenols, terpenoids, natural pigments, and otherwise, in the activation of Nrf2 signaling and their potential therapies for TBI. Although there is still limited clinical application evidence for these natural Nrf2 activators, we believe that the combinational use of phytochemicals such as Nrf2 activators with gene and stem cell therapy will be a promising therapeutic strategy for TBI in the future.

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Section: The Potential Therapy Of Phytochemicals As Nrf2 Activators I...mentioning

confidence: 99%

Targeting Nrf2-Mediated Oxidative Stress Response in Traumatic Brain Injury: Therapeutic Perspectives of Phytochemicals

Yong

Pan

et al. 2022

Oxidative Medicine and Cellular Longevity

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“…Injectable hydrogels are a new class of wound healers that permit the moisture of wounds and oxygen permeability. Recently, boronic ester dynamic injectable hydrogels were developed as a novel self-healing, dual-stimuli-responsive, antioxidant, and antibacterial class of materials for healing of chronic wounds [ 180 ].…”

Section: Wound Dressingsmentioning

confidence: 99%

Special Features of Polyester-Based Materials for Medical Applications

Darie-Niță¹,

Râpă

Frąckowiak

2022

Polymers

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This article presents current possibilities of using polyester-based materials in hard and soft tissue engineering, wound dressings, surgical implants, vascular reconstructive surgery, ophthalmology, and other medical applications. The review summarizes the recent literature on the key features of processing methods and potential suitable combinations of polyester-based materials with improved physicochemical and biological properties that meet the specific requirements for selected medical fields. The polyester materials used in multiresistant infection prevention, including during the COVID-19 pandemic, as well as aspects covering environmental concerns, current risks and limitations, and potential future directions are also addressed. Depending on the different features of polyester types, as well as their specific medical applications, it can be generally estimated that 25–50% polyesters are used in the medical field, while an increase of at least 20% has been achieved since the COVID-19 pandemic started. The remaining percentage is provided by other types of natural or synthetic polymers; i.e., 25% polyolefins in personal protection equipment (PPE).

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“…Another boronic ester dynamic covalent bond based self-healing hydrogel using phenyl boronic acid-modified hyaluronic acid (HA-PBA) and plant-derived polyphenol-tannic acid (TA) was developed by Shi et al They have also used TA for the synthesis of silver nanoparticles within the hydrogel, which have antibacterial properties. The hydrogel was found to have dual (pH-and reactive oxygen species (ROS)) responsive properties as well as enhanced antioxidant properties [156].…”

Section: Self-healing Hydrogels As Drug Delivery Platforms For Antimicrobial Therapymentioning

confidence: 99%

Self-Healing Hydrogels: Preparation, Mechanism and Advancement in Biomedical Applications

Shyam

Palaniappan

et al. 2021

Polymers

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Polymeric hydrogels are widely explored materials for biomedical applications. However, they have inherent limitations like poor resistance to stimuli and low mechanical strength. This drawback of hydrogels gave rise to ‘‘smart self-healing hydrogels’’ which autonomously repair themselves when ruptured or traumatized. It is superior in terms of durability and stability due to its capacity to reform its shape, injectability, and stretchability thereby regaining back the original mechanical property. This review focuses on various self-healing mechanisms (covalent and non-covalent interactions) of these hydrogels, methods used to evaluate their self-healing properties, and their applications in wound healing, drug delivery, cell encapsulation, and tissue engineering systems. Furthermore, composite materials are used to enhance the hydrogel’s mechanical properties. Hence, findings of research with various composite materials are briefly discussed in order to emphasize the healing capacity of such hydrogels. Additionally, various methods to evaluate the self-healing properties of hydrogels and their recent advancements towards 3D bioprinting are also reviewed. The review is concluded by proposing several pertinent challenges encountered at present as well as some prominent future perspectives.

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Tannic acid-inspired, self-healing, and dual stimuli responsive dynamic hydrogel with potent antibacterial and anti-oxidative properties

Abstract: Due to their intrinsic injectable and self-healing characteristics, dynamic hydrogels, based on dynamic covalent bonds, have gained a great attention. In this study, a novel dynamic hydrogel based on the...

Cited by 92 publications

References 67 publications

Targeting Nrf2-Mediated Oxidative Stress Response in Traumatic Brain Injury: Therapeutic Perspectives of Phytochemicals

Targeting Nrf2-Mediated Oxidative Stress Response in Traumatic Brain Injury: Therapeutic Perspectives of Phytochemicals

Special Features of Polyester-Based Materials for Medical Applications

Self-Healing Hydrogels: Preparation, Mechanism and Advancement in Biomedical Applications

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