Tannic acid-mediated dual peptide-functionalized scaffolds to direct stem cell behavior and osteochondral regeneration

Zhang, Wei; Chen, Ling; Liu, Haoyang; Zhang, Aini; Mao, Lu; Wang, Jing; Chao, Jie; Backman, Ludvig J.; Yao, Qingqiang; Chen, Jialin

doi:10.1016/j.cej.2020.125232

Cited by 49 publications

(67 citation statements)

References 47 publications

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“…There is information in the literature about the positive effect of TA-enriched scaffolds on osteogenic differentiation in BMSC cells [ 38 ]. Our research shows a stimulating effect on the proliferation of hPDL cells, which are also considered osteogenic [ 39 , 40 ].…”

Section: Discussionmentioning

confidence: 99%

The Preparation and Characterization of Chitosan-Based Hydrogels Cross-Linked by Glyoxal

Kaczmarek-Szczepańska

Mazur

Michalska‐Sionkowska

et al. 2021

Materials

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In this study, hydrogels based on chitosan cross-linked by glyoxal have been investigated for potential medical applications. Hydrogels were loaded with tannic acid at different concentrations. The thermal stability and the polyphenol-releasing rate were determined. For a preliminary assessment of the clinical usefulness of the hydrogels, they were examined for blood compatibility and in the culture of human dental pulp cells (hDPC). The results showed that after immersion in a polyphenol solution, chitosan/glyoxal hydrogels remain nonhemolytic for erythrocytes, and we also did not observe the cytotoxic effect of hydrogels immersed in tannic acid (TA) solutions with different concentration. Tannic acid was successfully released from hydrogels, and its addition improved material thermal stability. Thus, the current findings open the possibility to consider such hydrogels in clinics.

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Section: Discussionmentioning

confidence: 99%

The Preparation and Characterization of Chitosan-Based Hydrogels Cross-Linked by Glyoxal

Kaczmarek-Szczepańska

Mazur

Michalska‐Sionkowska

et al. 2021

Materials

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“…C. The dual E7/P15 peptide-functionalized monophasic scaffolds mediated by tannic acid (TA) enhanced the recruitment of BMSCs and promote simultaneously the regeneration of cartilage and subchondral bone. Reproduced with permission [ 228 ]. 2020, Elsevier.…”

Section: Strategies Of the Scaffolds For Cartilage And Osteochondral Tissue Engineeringmentioning

confidence: 99%

“…In spite of the universally accepted recognition about the poor structural similarity between monophasic scaffolds and the native stratified osteochondral tissues, several recent studies have reported appealing findings about the concurrent regeneration of cartilage and subchondral bone in the rabbit model using these seemingly simple scaffolds [ 160 , 161 , 171 , 174 , 177 , 184 , 227 , 228 ]. The released ions of Mn 2+ , Sr 2+ , Si 4+ , Li + , Cu 2+ from the bioceramics were demonstrated to play an important role in the related inflammatory and regeneration process [ 160 , 161 , 171 , 174 , 177 , 184 ].…”

Section: Strategies Of the Scaffolds For Cartilage And Osteochondral Tissue Engineeringmentioning

confidence: 99%

“…( Fig. 4 B) Zhang et al prepared the dual peptide-functionalized monophasic scaffolds mediated by tannic acid and also presented the satisfactory biological performance in MSCs recruitment and simultaneous regeneration of cartilage and subchondral bone [ 228 ]. ( Fig.…”

Section: Strategies Of the Scaffolds For Cartilage And Osteochondral Tissue Engineeringmentioning

confidence: 99%

“…Hence, it requires an overall knowledge of both the two tissues and moreover an in-depth comprehension on the osteochondral interface and its complex relationship and interaction with cartilage and bone. The first explored monophasic scaffolds containing a uniform composition and architecture neglect the special stratified feature of the osteochondral unit [ 78 , 228 ]. Later studies developed the biphasic scaffolds that can simultaneously promote the regeneration of both cartilage and bone in the two individual layers without considering the intermediate calcified cartilage [ 114 , 234 ].…”

Section: Current Challenges and Future Directionsmentioning

confidence: 99%

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Articular cartilage and osteochondral tissue engineering techniques: Recent advances and challenges

Wei

Dai

2021

Bioactive Materials

194

161

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In spite of the considerable achievements in the field of regenerative medicine in the past several decades, osteochondral defect regeneration remains a challenging issue among diseases in the musculoskeletal system because of the spatial complexity of osteochondral units in composition, structure and functions. In order to repair the hierarchical tissue involving different layers of articular cartilage, cartilage-bone interface and subchondral bone, traditional clinical treatments including palliative and reparative methods have showed certain improvement in pain relief and defect filling. It is the development of tissue engineering that has provided more promising results in regenerating neo-tissues with comparable compositional, structural and functional characteristics to the native osteochondral tissues. Here in this review, some basic knowledge of the osteochondral units including the anatomical structure and composition, the defect classification and clinical treatments will be first introduced. Then we will highlight the recent progress in osteochondral tissue engineering from perspectives of scaffold design, cell encapsulation and signaling factor incorporation including bioreactor application. Clinical products for osteochondral defect repair will be analyzed and summarized later. Moreover, we will discuss the current obstacles and future directions to regenerate the damaged osteochondral tissues.

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Smart Biomaterials for Articular Cartilage Repair and Regeneration

Wang

et al. 2023

Adv Funct Materials

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Articular cartilage defects bring about disability and worldwide socioeconomic loss, therefore, articular cartilage repair and regeneration is recognized as a global issue. However, due to its avascular and nearly acellular characteristic, cartilage tissue regeneration ability is limited to some extent. Despite the availability of various treatment methods, including palliative drugs and surgical regenerative therapy, articular cartilage repair and regeneration still face major challenges due to the lack of appropriate methods and materials. Smart biomaterials can regulate cell behavior and provide excellent tissue repair and regeneration microenvironment, thus inducing articular cartilage repair and regeneration. This process is adjusted by controlling drug/bioactive factors release via responding to exogenous/endogenous stimuli, tailoring materials’ structure and function similar to native cartilage or providing physiochemical and physical signaling factors. Herein, smart biomaterials, recently applied in articular cartilage repair and regeneration, are elaborated from two aspects: smart drug release system and smart scaffolds. Furthermore, articular cartilage and its defects and advanced manufacturing techniques of smart biomaterials are discussed in brief. Finally, perspectives for smart biomaterials used in articular cartilage repair and regeneration are presented and the clinical translation of smart biomaterials is emphasized.

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Tannic acid-mediated dual peptide-functionalized scaffolds to direct stem cell behavior and osteochondral regeneration

Cited by 49 publications

References 47 publications

The Preparation and Characterization of Chitosan-Based Hydrogels Cross-Linked by Glyoxal

The Preparation and Characterization of Chitosan-Based Hydrogels Cross-Linked by Glyoxal

Articular cartilage and osteochondral tissue engineering techniques: Recent advances and challenges

Smart Biomaterials for Articular Cartilage Repair and Regeneration

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