Tannic acid post-treatment of enzymatically crosslinked chitosan-alginate hydrogels for biomedical applications

An injectable, self-healing, 3D printable, double network co-enzymatically crosslinked hydrogel using marine poly- and oligo-saccharides for wound healing application

“…Furthermore, the UV spectra (Fig. 2C) displayed a new peak at 275 nm for Ch-Ph, which aligns with the 1 H NMR results confirming the successful conjugation of propionic acid on the chitosan backbone [88].…”

Tannic acid: a versatile polyphenol for design of biomedical hydrogels

“…For example, the free radical polymerization can hardly be performed due to TA's strong free-radical scavenging ability. 235,368 Moreover, crosslinking via oxidation of phenolic groups using enzymatic crosslinking can be hindered in the presence of TA owing to the scavenging activity of TA, as well as inhomogeneity due to the complexation of TA with a wide range of polymers.…”

Enzymatically-Crosslinked Gelatin Hydrogels with Nanostructured Architecture and Self-Healing Performance for Potential Use as Wound Dressings

“…These limitations generated by crosslinking methods can be overcome by using enzymes to form covalently crosslinked hydrogels. Enzyme-mediated crosslinking by tyrosinases [ 16 ], transferases [ 17 ] or peroxidases [ 18 ] have proven their efficiency and therefore, they have attracted increasing attention for application in polymer hydrogel synthesis due to the environmentally-friendly process and the possibility of obtaining biomaterials with extracellular matrix-mimicking properties. Transglutaminase (TGase), a widely present enzyme in nature, has been demonstrated to catalyze the formation of isopeptide bonds between proteins by mimicking in vivo biosynthetic processes, which can significantly improve protein gelation [ 19 , 20 ].…”