Tannic acid–thioctic acid hydrogel: a novel injectable supramolecular adhesive gel for wound healing

Abstract

Skin tissue defects make a major threat to human health. It is of vital importance for researchers to develop ideal novel adhesives with strong adhesion, good biocompatibility, low cost and...

Tannic acid: a crosslinker leading to versatile functional polymeric networks: a review

“…14 ). 131 Owing to the chemical crosslinking as well as supramolecular assembly of the TATA matrix, the TATA hydrogel exhibited strong tissue adhesion, desirable biocompatibility, and biodegradability with minimal inflammatory response. Thus, the TATA hydrogel is promising for use as an injective tissue adhesive.…”

Biomimetic Hydrogels to Promote Wound Healing

“…Generally, the type of polymer crosslinking can be categorized into physical and chemical crosslinking ( Figure 3 ). Physical crosslinking includes hydrogen ( Chen et al, 2021 ) and ionic bonds ( Johnson et al, 2020 ), as well as hydrophobic ( Wei et al, 2019 ), and supramolecular interactions ( Zhao et al, 2020a ). Physical crosslinking renders hydrogels self-healing and injectable due to their weak physical interactions.…”

“…Usually, the sprayable hydrogels are formed in situ rapidly through physical crosslinking ( Kumar and Jaiswal, 2016 ), Schiff base bond formation ( Du et al, 2020 ), and crosslinking of phenol groups ( Sun et al, 2020 ). Functional hydrogel can be constructed through incorporating antimicrobial peptide ( Annabi et al, 2017 ) and cerium oxide nanoparticles ( Cheng et al, 2021 ) to improve antibacterial activities and ROS-scavenging abilities. Cell-attracting chemotactic cytokines could be delivered by sprayable hydrogel for diabetic wound treatment ( Yoon et al, 2016 ).…”

A Review on Hydrogels with Photothermal Effect in Wound Healing and Bone Tissue Engineering

“…Researchers have developed different kinds of hydrogels that are suitable for different defect sites. Injectable hydrogels can complete sol-gel conversion in a short time via hydrogen bonds [ 15 , 16 ], host–guest interactions [ 17 ], dynamic Schiff bonds [ 18 ], dynamic diol-borate ester crosslinking [ 19 ], and the Diels−Alder reaction [ 20 ]. Hence, injectable hydrogels can be applied to irregular defect areas.…”