Tannin as a gatekeeper of pH-responsive mesoporous silica nanoparticles for drug delivery

Abstract

Tannin grafted on mesoporous silica nanoparticles (tannin-MSNs) was synthesized by the amidation reaction of carboxyl benzyl borate with amino group modified MSN. Tannin-MSNs were an MCM-41 type of mesoporous material with a uniform diameter of about 150 nm. The XRD and N 2 adsorption/ desorption isotherm results demonstrated that the rhodamine was effectively loaded and the pores of MSN were blocked by tannin. Rhodamine as a model cargo was used to evaluate the loading and releasing behaviors of tannin-MSNs. The drug release rate of tannin-MSNs was pH dependent. An in vitro cellular cytotoxicity test indicated that tannin-MSNs were highly biocompatible and suitable to be used as drug carriers. The cellular uptake was investigated by confocal laser scan microscopy. The results showed that tannin-MSNs are promising platforms to construct a pH-responsive controlled drug delivery system for cancer and stomach therapy.

Mesoporous Silica Nanoparticles: A Comprehensive Review on Synthesis and Recent Advances

“…Tannins as pH motifs were proved by the work of Hu and collaborators. Tannins, by the formation of boronate esters were found to modulate the release of the dye rhodamine at acidic pH [ 211 ].…”

Mesoporous silica nanoparticles for stimuli-responsive controlled drug delivery: advances, challenges, and outlook

“…With a gradually increase in studies, a series of MSN-based stimuli-responsive systems have been reported. 34,35 The drug release is subsequently to be triggered by environmental stimuli including physical signals (eg, temperature, 36,37 electricity, 38 magnetic field, 39 and photons [40][41][42] ) and chemical signals (eg, pH values, 43 redox potential, [44][45][46] and enzymatic activities 47,48 ). In this review, we intend to discuss about the advanced progress related to MSN for drug delivery associated with special focus on environmental responsive mechanisms and highlight the effect of endogenous stimuli in drug delivery such as pH, redox, enzyme, ATP, glucose, and H 2 O 2 , as well as exogenous stimuli including thermo, light, ultrasound, and magnetic field.…”

A Green Approach for the Synthesis of Drug Delivery System, Mesoporous Silica Grafted Acrylamide –Β- Cyclodextrin Composite, for the Controlled Release of Curcumin

“…Because of the intercalation of the APS, the basal spacing of APSB was increased [27]. The copolymer hydrogel, AMCD can act as a "gate keeper" molecule in which it can be introduced to the tuning pore size of the clay for the effective loading and the controlled release of drug [28][29][30]. During the synthesis of AMCD from β-CD and AAm, CAN was used as the free radical initiator.…”