Tannins as Hepatic Carcinogens

Korpassy, B

doi:10.1159/000385955

Cited by 47 publications

(7 citation statements)

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“…There is therefore no evidence from the present study of any interesting link between the supposed water factor in the aetiology of certain forms of malignant and cardiovascular disease, on the one hand, and the polyphenolic substances present in tea infusions, on the other. It may be noted from Table 1 that these polyphenolic flavonoid substances constitute approximately half the total amount of solid material present in the infusions and that the average daily intake of tea polyphenols in the United Kingdom is about 2 g. The recent reports (Korpassy, 1961;Kaiser, 1967) which raise the question whether the continual ingestion of these substances in tea might present either a carcinogenic or cocarcinogenic risk to man should encourage further investigation of their biological activity.…”

Section: Discussionmentioning

confidence: 99%

“…In this connexion, since a major part of the culinary use of water is associated with the cooking of vegetable materials and particularly with the preparation of beverages such as tea and coffee, information on the interactions of water calcium and the components of these materials is of prime interest. Further interest is directed to the composition of tea infusions by the demonstration, in studies with laboratory animals, that several vegetable tannin extracts possess carcinogenic properties (Kirby, 1960;Korpassy, 1961) and also that tea extracts possess co-carcinogenic properties (Kaiser, 1967).…”

Section: Introductionmentioning

confidence: 99%

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The composition of tea infusions examined in relation to the association between mortality and water hardness

Anderson

Hollins

Bond

1971

J. Hyg.

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SUMMARYRecent epidemiological studies have shown that death-rates from certain chronic diseases are higher in areas with soft than in areas with hard drinkingwater. In the striking negative correlation found in the county boroughs of England and Wales between cardiovascular mortality and water hardness the important underlying factor is apparently the water calcium. Interest is therefore focused on the dietary significance of calcium present in drinking-water. In relation to that interest, the present report gives a quantitative account of the composition of tea infusions prepared with waters containing different amounts of calcium. It is shown that a substantial part of water calcium is taken up by the tea leaf during the preparation of infusions. The analysis of the infusions covers a wide range of individual components, including trace metals and polyphenolic substances. It appears that the principal change caused in infusion composition by the presence of calcium in the water is a substantial reduction in the relatively high oxalate content. The question is raised whether there may be some connexion between the 'water factor' in cardiovascular disease and the absorption of oxalates from foods.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The composition of tea infusions examined in relation to the association between mortality and water hardness

Anderson

Hollins

Bond

1971

J. Hyg.

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“…Scientific references report evident correlation between dietary polyphenols rich diets and health enhancing properties: antioxidant properties [11][12][13], antibacterial activity on different bacterial strains in vitro and in vivo [7,[14][15][16][17][18][19][20], antiparasitic [21], antiulcerogenic [22][23][24] antidiarrhoic [25], antimutagenic [26][27][28][29][30][31][32][33], antitumor [34][35][36][37][38], and some neoplastic cell line apoptosis [39,40]. On the other hand, high tannins diets might also result in detrimental effects like hepatotoxicity [41,42], toxic nephrosis [43], oesphageal cancer [44], depression of feed intake and growth rate in many animal species [45][46][47][48][49][50][51].…”

Section: Biological Role Of Polyphenolsmentioning

confidence: 99%

Dose-Response Relationship between Dietary Polyphenols from Acorns and Parotid Gland Hypertrophy in Pigs

Cappai¹,

Wolf²,

Pinna³

et al. 2012

FNS

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Proline contents of parotid glands (PG) in pigs constantly increase after the inclusion of different amounts of ripe hulled acorns in the diet providing high polyphenols levels. The dose-response relationship was estimated on natural hydrolizable tannins (expressed as tannic acid equivalent TAE) amounts of 25.8 to 36.1 g TAE/kg DM in experimental diets. Macroscopic and histological morphometry of parotid glands greatly varied according to feed intake and dosages of TAE ingested. The PG response (hypertrophy grade) on acorns' tannins content in the diet was positively correlated (R 2 = 0.748): the response to the protein precipitating activity (PPA) of tannins consisted of a functional parotidomegaly (hypertrophy), 1.34 up to 3.55 folds than control PGs, following an oral dosage 0.596 up 1.72 TAE g·kg -1 body weight·d -1 respectively, after one week exposure.

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“…Many other investigators reported that tannins are carcinogenic [15,16,23], Several terpinoids found in black pepper such as rZ-limonene, L-pinene, linalool and phillandrene are reported to be potential car cinogens, cocarcinogens or tumour promotors [9,12]. Homburger and Boger [12] reported that r/-limonene is a skin tumour-promoting agent in mice.…”

Section: Introductionmentioning

confidence: 99%

Carcinogenicity Testing of Black Pepper (Piper nigrum) Using the Egyptian Toad <i>(Bufo regularis) </i>as a Quick Biological Test Animal

El‐Mofty

Soliman²,

Abdel-Gawad³

et al. 1988

Oncology

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Milled black pepper (Piper nigrum) force-fed to Egyptian toads as a suspension in amphibian saline or injected subcutaneously in the dorsal lymph sac as an ethanol extract, induced primary tumours in the liver and secondary tumours in other organs (kidney and spleen). When applied to the skin of experimental animals as an ethanol extract, black pepper induced primary tumours in the liver and secondary tumours in the ileum and stomach. Tumours of the liver were diagnosed as hepatocellular carcinomas and those of the other organs as metastases of the primary liver tumours. It is speculated that one or more constituents of black pepper may be responsible for tumour induction in the organs of the Egyptian toad Bufo regularis.

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Tannins as Hepatic Carcinogens

Cited by 47 publications

References 0 publications

The composition of tea infusions examined in relation to the association between mortality and water hardness

The composition of tea infusions examined in relation to the association between mortality and water hardness

Dose-Response Relationship between Dietary Polyphenols from Acorns and Parotid Gland Hypertrophy in Pigs

Carcinogenicity Testing of Black Pepper (Piper nigrum) Using the Egyptian Toad <i>(Bufo regularis) </i>as a Quick Biological Test Animal

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