Tannins, Peptic Ulcers and Related Mechanisms

Jesus, Neyres Zínia Taveira de; Falcão, Heloina de Souza; Gomes, Isis Fernandes; Leite, Thiago Jose de Almeida; Lima, Gedson Rodrigues de Morais; Barbosa-Filho, José Maria; Tavares, Josean Fechine; Silva, Marcelo Sobral da; Athayde-Filho, Petrônio Filgueiras de; Batista, Leônia Maria

doi:10.3390/ijms13033203

Cited by 143 publications

(86 citation statements)

References 100 publications

(64 reference statements)

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“…Flavonoids have also been shown to increase the viability and proliferation of fibroblasts [36]. Tannins have antioxidant effect and may act in similar fashion to promote collagen deposition [37]. They also increase angiogenesis by increasing vascular endothelial growth factor formation, thus maintaining adequate supply of oxygen necessary for collagen stability [38].…”

Section: Discussionmentioning

confidence: 99%

Effect of Ethanolic Extract of Cyanotis Cristata Leaves Applied Topically on Wound Healing in Wistar Rats

Pathak

Shenoy

Kiran

et al. 2017

Asian J Pharm Clin Res

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Objective: The objective of this study was to assess the effect of ethanolic extract of Cyanotis cristata leaves when applied topically on healing of wound in Wistar rats. Methods:C. cristata leaves were evaluated for its effect on healing of wound in three models, namely, incision, excision, and burn wound. Each model included five groups, each consisting of 6 rats. The five groups were as follows: Group I rats (control and ointment base), Group II rats (standard and silver sulfadiazine), and Group III, Group IV, Group V (treated with C. cristata extract ointment of 0.5%, 1%, and 2%, respectively). Variables evaluated included breaking strength in incision wound while it was contraction rate and epithelialization in excision and burn wound. One-way analysis of variance and Tukey's post hoc test was used to analyze data. Result:In incision wound, breaking strength in test group was significantly increased (p<0.001) as compared to control. In excision and burn wound of test group, time to epithelialization and contraction rate was significantly decreased (p<0.001). The granulation tissue from excision and burn wound showed increased collagen and less inflammatory cells in test groups in comparison to the control. Conclusion:The ethanolic extract of leaves of C. cristata, when applied topically, enhanced wound strength and accelerated healing of incision, excision, and burn wounds in rats.

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Section: Discussionmentioning

confidence: 99%

Effect of Ethanolic Extract of Cyanotis Cristata Leaves Applied Topically on Wound Healing in Wistar Rats

Pathak

Shenoy

Kiran

et al. 2017

Asian J Pharm Clin Res

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“…Moreover compounds like tannic acid and purpurin are active free radical scavengers. [55,56,57] Presence of a major lichen compound, usnic acid also has potent antioxidant capacities. [58] Similarly newer lichen specific compounds have gained priorities in recent antioxidant research.…”

Section: Discussionmentioning

confidence: 99%

ASSESSMENT OF THE ANTIOXIDANT ACTIVITY AND PHYTOCHEMICAL ANALYSIS OF A LICHEN, EVERNIASTRUM CIRRHATUM (FR.) HALE ex. SIPMAN

Mandal¹

2017

WJPPS

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Free radicals generated in system induce oxidative stress related diseases. Recent research is focused on plants and phytocompounds to avoid various side effects. The present study is aimed to evaluate the free radical scavenging potential along with phytochemical screening of the 70% methanolic extract of a lichen, Everniastrum cirrhatum (Fr.) Hale (ECME). ECME was tested for its in vitro total antioxidant capacities and various other reactive oxygen and nitrogen species (ROS, RNS) scavenging potentials. For further insight, phytochemical screening through qualitative and quantitative analyses along with HPLC standardization were performed. It was observed that ECME showed total antioxidant capacity with TEAC value of 0.384 ± 0.0074 as compared to Trolox. The lichen also showed excellent ROS and RNS scavenging capacities as it scavenges hydroxyl, superoxide, hypochlorous acid, nitric oxide and peroxynitrite radicals with IC 50 values of 208. 09 ± 6.36, 142.26 ± 3.17, 150.07 ± 3.01, 118.19 ± 5.99 and 3037.07 ± 222.43 µg/ml respectively. Singlet oxygen is also scavenged but to a lesser extent by ECME. Phytochemical analyses of ECME showed greater presence of alkaloids, phenolics, flavonoids like compounds as compared to other phytocompounds.Moreover HPLC analysis of ECME revealed the presence of antioxidant phytochemicals like purpurin, usnic acid, tannic acid, reserpine and rutin at various retention times. The in vitro results show that ECME possesses promising antioxidant and free radical scavenging

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“…Protocatechuic acid, p-hydroxy benzoic acid, Vanillic acid, Caffeic acid, Syringic acid, p-coumaric acid [20] [29] Anticancer activity Anti-proliferative effect to resist uncontrolled cell proliferation, Inhibit evasion of apoptosis and metastasis. [31] Antimicrobial activity…”

Section: Plant Parts Phytoconstituents Leavesmentioning

confidence: 99%

“…Some studies also exhibit the effect of tannins against Helicobacter pylori infection. [29] The percolated ethanolic extract of stem barks of the plant Schleichera oleosa (Lour.) Oken.…”

Section: Anti-inflammatory and Associated Analgesic Activitymentioning

confidence: 99%

Ayurvedic, Phytochemical and Pharmacological Review of Schleichera Oleosa (Lour.) Oken: A Traditional Plant With Enormous Biological Activity

Goswami¹

2017

WJPR

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Schleichera oleosa (Lour) Oken., a member of Sapindaceae family, is found in South East Asia region and in sub-Himalayan tract of India.This plant is long been used in India as a folkloric plant for its enormous therapeutic effects and as livestock feeds. The plant is used in helminthiasis, acne, itching, menorrhea, malaria, dysentery, rheumatism, hair loss in Ayurveda and evaluated scientifically for antiinflammatory, antiulcer, anticancer, antibacterial and antioxidant effects. Phenolic compounds, fatty acids, tannins, hydroxyl sterols and triterpenoids are the common active Phytoconstituents of this plant.The present study reviews the Vedic status, traditional uses, Ayurvedic properties, Phytoconstituents, chemistry and biological effects of Schleichera oleosa and describes as a potential plant for the source of various therapeutic agents.

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Tannins, Peptic Ulcers and Related Mechanisms

Cited by 143 publications

References 100 publications

Effect of Ethanolic Extract of Cyanotis Cristata Leaves Applied Topically on Wound Healing in Wistar Rats

Effect of Ethanolic Extract of Cyanotis Cristata Leaves Applied Topically on Wound Healing in Wistar Rats

ASSESSMENT OF THE ANTIOXIDANT ACTIVITY AND PHYTOCHEMICAL ANALYSIS OF A LICHEN, EVERNIASTRUM CIRRHATUM (FR.) HALE ex. SIPMAN

Ayurvedic, Phytochemical and Pharmacological Review of Schleichera Oleosa (Lour.) Oken: A Traditional Plant With Enormous Biological Activity

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