Tanshinone IIA Protects Against Folic Acid-Induced Acute Kidney Injury

Jiang, Chunming; Zhu, Wei; Shao, Qiuyuan; Xiang, Yan; Jin, Bo; Zhang, Miao; Xu, Baojun

doi:10.1142/s0192415x16500403

Cited by 25 publications

(15 citation statements)

References 47 publications

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“…Terpen glycosides from Cortex Moutan, the root bark of Paeonia suffruticosa , reduced inflammatory cytokines including IL-6, MCP-1, and intercellular adhesion molecule 1 (ICAM-1), in a rat model of diabetic nephropathy [98]. In a folic acid-induced kidney injury model in mice, systemic administration of Tanshinone IIA, a diterpene and one of the abundant constituents of Salvia Miltiorrhiza , resulted in improved kidney function with a concomitant reduction in chemokine expression [99]. Tanshinone IIA also suppressed renal fibrosis and inflammation as assessed by a decrease in cytokines TNF-α, MCP-1, and the chemokine CXCL-1, in a rat model of CKD induced by nephrectomy [100].…”

Section: Inflammationmentioning

confidence: 99%

The Benefit of Anti-Inflammatory and Renal-Protective Dietary Ingredients on the Biological Processes of Aging in the Kidney

Panickar

Jewell

2018

Biology

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One of the significant organ systems which decline in aging is the kidney. While the causes of age-associated decline in renal function are likely multifactorial, oxidative stress and inflammation are hypothesized to play important roles in the structural and functional changes of the kidney. During aging there is a general decline in the glomerular filtration rate (GFR), a primary measurement used to assess kidney function. Inflammation and oxidative stress have been hypothesized to have a significant detrimental effect on renal function in aging and this may be attenuated by renal protective dietary ingredients. These dietary ingredients may affect renal function directly or through a microbiome-mediated secondary product. Likewise, structural changes including renal tubular atrophy, interstitial fibrosis, and glomerulosclerosis have all been described in aging. Such detrimental changes may benefit from dietary ingredients that may delay or attenuate the occurrence of such changes. This review will describe the physiology and pathophysiology of aging in renal function with an emphasis on dogs and cats that develop a decline in kidney function naturally. In addition, the varying biomarkers of health and renal dysfunction will be discussed. Finally, we will evaluate the aid in the management of this normal decline through dietary intervention in animal models.

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Section: Inflammationmentioning

confidence: 99%

The Benefit of Anti-Inflammatory and Renal-Protective Dietary Ingredients on the Biological Processes of Aging in the Kidney

Panickar

Jewell

2018

Biology

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“…Tanshinone IIA is used for treating cardiovascular diseases including cardiac hypertrophy, heart failure and myocardial ischaemia‐reperfusion injury, which could improve heart function by reducing the degree of fibrosis and inhibiting the apoptosis of cardiomyocytes 9. It has been reported that tanshinone IIA is a popular and safe herb medicine, which showed a protective effect on the endothelial cells 10. In addition, tanshinone IIA has been shown to attenuate inflammatory pathways, increase the blood vessels, improve the haemodynamics, dilate the coronary arteries to increase perfusion and enhance myocardial contractility 11.…”

Section: Introductionmentioning

confidence: 99%

“…9 It has been reported that tanshinone IIA is a popular and safe herb medicine, which showed a protective effect on the endothelial cells. 10 In addition, tanshinone IIA has been shown to attenuate inflammatory pathways, increase the blood vessels, improve the haemodynamics, dilate the coronary arteries to increase perfusion and enhance myocardial contractility. 11 Nuclear factor kappa B (NF-jB) has been known to be a significant transcription factor in a living organism for the functioning of nearly all cells.…”

Section: Introductionmentioning

confidence: 99%

Retracted: Tanshinone IIA prevents left ventricular remodelling via the TLR4/MyD88/NF‐κB signalling pathway in rats with myocardial infarction

Wang

Han

et al. 2018

J Cellular Molecular Medi

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In this study, we aim to investigate the role of tanshinone IIA in myocardial infarction (MI), especially in left ventricular remodelling (VR) and the underlying mechanism involving the TLR4/MyD88/NF‐κB signalling pathway. Sprague‐Dawley (SD) rats (n = 96) were selected, and 12 of them underwent sham surgery. The remaining 84 rats were subjected to MI modelling. HE and MT staining were carried out to estimate infract size, histopathological changes and fibrosis degree. Macrophage infiltration and cardiomyocyte apoptosis were evaluated by immunohistochemistry and TUNEL staining. Reverse transcription quantitative polymerase chain reaction (RT‐qPCR) and Western blotting were used to determine the expression levels of TLR4, MyD88 and NF‐κB. Serum levels of IL‐2, IL‐6, IL‐8, TNF‐a, procollagen I Cpropeptide (PICP), and procollagen III N‐propeptide (PIIINP) were measured using enzyme‐linked immunosorbent assay (ELISA). The heart weight/body weight, mean arterial pressure (MAP), left ventricular end‐systolic pressure (LVESP), +dP/dt and −dP/dt increased while the ventricular function and the left ventricular end‐diastole pressure (LVEDP) decreased in MI rats. Compared with the rats undergoing sham surgery, MI rats showed larger infarct size, severer fibrosis, higher expression levels of TLR4, NF‐κB‐P65, MyD88, IL‐2, IL‐6, IL‐8, TNF‐a, PICP and PIIINP as well as enhanced macrophage infiltration, cardiomyocyte apoptosis. After treatment with tanshinone IIA combined with LPS for 4 weeks, the rats showed better condition than those treated with only LPS. These results indicate that tanshinone IIA attenuates MI and prevents left VR. Importantly, inhibition of TLR4/MyD88/NF‐κB signalling pathway is a key step in this process.

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“…The results of the present study revealed that tanshinone IIA significantly inhibited the increased levels of TNF-α, IL-1β and IL-6 in the SCP rats. Jiang et al also suggested that tanshinone IIA protects against folic acid-induced acute kidney injury through inhibition of the inflammatory response (17).…”

Section: Discussionmentioning

confidence: 99%

Neuroprotective effect of tanshinone IIA weakens spastic cerebral palsy through inflammation, p38MAPK and VEGF in neonatal rats

et al. 2017

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As one of main active ingredients of salvia miltiorrhizae, which is a traditional Chinese medicine, tanshinone IIA is the basis of its pharmacological activities. In the present study, the effect of tanshinone IIA on weakening spastic cerebral palsy (SCP) in neonatal rats was investigated. Radial arm water maze and holding tests were used to measure the alterations of spastic cerebral palsy, inflammation was measured using an ELISA kit, and western blot analysis was used to analyze the protein expression of p‑p38 mitogen‑activated protein kinase (MAPK) and vascular endothelial growth factor (VEGF). The central mechanisms involved in the mediation or modulation of inflammation, p‑p38 MAPK and VEGF were also investigated. Treatment with tanshinone IIA effectively inhibited spastic cerebral palsy, and the activities of interleukin (IL)‑1β, IL‑6, tumor necrosis factor‑α, monocyte chemoattractant protein 1, cyclooxygenase‑2 and prostaglandin E2 in a neonatal rat model of SCP. Tanshinone IIA effectively suppressed the protein expression of inducible nitric oxide synthase (NOS), phosphorylated (p‑) nuclear factor (NF)‑κB, p‑p38MAPK and VEGF, and activated the phosphorylation of inhibitor of NF‑κB and the protein expression of neuronal NOS in the SCP rat model. These results suggested that the neuroprotective effect of tanshinone IIA weakened SCP through inflammation, p38MAPK and VEGF in the neonatal rats.

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Tanshinone IIA Protects Against Folic Acid-Induced Acute Kidney Injury

Cited by 25 publications

References 47 publications

The Benefit of Anti-Inflammatory and Renal-Protective Dietary Ingredients on the Biological Processes of Aging in the Kidney

The Benefit of Anti-Inflammatory and Renal-Protective Dietary Ingredients on the Biological Processes of Aging in the Kidney

Retracted: Tanshinone IIA prevents left ventricular remodelling via the TLR4/MyD88/NF‐κB signalling pathway in rats with myocardial infarction

Neuroprotective effect of tanshinone IIA weakens spastic cerebral palsy through inflammation, p38MAPK and VEGF in neonatal rats

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