Tanshinone IIA Protects Ischemia/Reperfusion‐Induced Cardiomyocyte Injury by Inhibiting the HAS2/FGF9 Axis
Yanzhe Wang,
Weixin Sun,
Le Shen
et al.
Abstract:Purpose. This study aimed to investigate the impacts of tanshinone IIA (Tan IIA) on ischemia/reperfusion (I/R)‐induced cardiomyocyte injury in coronary heart disease (CHD), and to determine whether Tan IIA regulates myocardial cell injury induced by I/R through the Hyaluronan Synthase 2/fibroblast growth factor 9 (HAS2/FGF9) axis. Methods. Weighted gene co‐expression network analysis (WGCNA) of the GSE23561 microarray dataset determined gene modules linked to CHD. The key genes were further explored through di… Show more
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