Tanshinone IIA Rapid Analysis of Jingutongxiao Pills by Near-Infrared Spectroscopy

Abstract

Traditional Chinese medicine(TCM) preparation has a long history in China，and now it is an important direction at the development of hospital preparations, because lacking of quality control technology, quality of the different production batch is not quite stable in the process of production. Therefore, to establish perfect, accurate, rapid quality evaluation method is the key to realize modernization of the traditional Chinese medicine preparation[1,2]. The paper establishes the quantitative analysis model for Tanshinone IIA in Jingutongxiao Pills by near-infrared spectral technology. Through the discussion of spectral wavelength, spectral pretreatment and principal component count, it was found that the second derivative combined with partial least squares (PLS) establishes a best quantitative calibration model. The correlation coefficient of calibration (R2)was 0.975 37, the Root Mean Square Error of Cross Validation (RMSECV) is 0.001 17 and the external prediction deviation (RMSEP) is 0.00174. It indicated that the near-infrared spectral technology could be used for rapid, accurate, nondestructive determination of Tanshinone IIA in Jingutongxiao Pills[3,4].