Tantalum markers in radiography

Aronson, A. Stefan; Jonsson, Nils; Alberius, Per

doi:10.1007/bf00355566

Cited by 34 publications

(9 citation statements)

References 11 publications

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“…Therefore, it is important to study the behavior of the cells on any nano-structure as a function of time before exploiting its use as an implant material. Tantalum metal has also been exploited as the material to engineer bone, dental implant [ 40 – 42 ] and also as a radiographic marker [ 43 ]. Moreover, once an implant geometry is experimentally verified to be apt for a particular application, various methodologies such as Nanoimprint lithography (NIL) as shown by Bergmair et al [ 44 ] or by indirect 3-Dimensional printing methods as demonstrated by Tamjid et al [ 45 ] can be employed to generate uniform nanotopographies of interest for improved bio-nanosurface interactions.…”

Section: Discussionmentioning

confidence: 99%

Spatial Control of Cell-Nanosurface Interactions by Tantalum Oxide Nanodots for Improved Implant Geometry

et al. 2016

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Nanotopological cues can be exploited to understand the nature of interactions between cells and their microenvironment to generate superior implant geometries. Nanosurface parameters which modulate the cell behavior and characteristics such as focal adhesions, cell morphology are not clearly understood. Here, we studied the role of different nanotopographic dimensions in modulating the cell behavior, characteristics and ultimately the cell fate and accordingly, a methodology to improve implant surface geometry is proposed. Tantalum oxide nanodots of 50, 100nm dot diameter with an inter-dot spacing of 20, 70nm and heights 40, 100nm respectively, were engineered on Silicon substrates. MG63 cells were cultured for 72 hours and the modulation in morphology, focal adhesions, cell extensible area, cell viability, transcription factors and genes responsible for bone protein secretion as a function of the nanodot diameter, inter-dot distance and nanodot height were evaluated. Nanodots of 50nm diameter with a 20nm inter-dot spacing and 40nm height enhanced cell spreading area by 40%, promoted cell viability by 70% and upregulated transcription factors and genes twice as much, as compared to the 100nm nanodots with 70nm inter-dot spacing and 100nm height. Favorable interactions between cells and all dimensions of 50nm nanodot diameter were observed, determined with Scanning electron microscopy and Immunofluorescence staining. Nanodot height played a vital role in controlling the cell fate. Dimensions of nanodot features which triggered a transition in cell characteristics or behavior was also defined through statistical analysis. The findings of this study provide insights in the parameters of nanotopographic features which can vitally control the cell fate and should therefore be taken into account when designing implant geometries.

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Section: Discussionmentioning

confidence: 99%

Spatial Control of Cell-Nanosurface Interactions by Tantalum Oxide Nanodots for Improved Implant Geometry

et al. 2016

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“…Moreover, new materials such as TiO 2 , PDMS 47 48 , TCPS 49 are also consistently used to study the nature and modulation of interactions between cells and its micro/nano environment as a function of the size of surface features 50 . Owing to its excellent X-Ray visibility and magnetic susceptibility, Tantalum has also been widely exploited in fabricating stents 51 . Quite interestingly, cells not only respond differently to different sized nano surface features but also to the different shapes and roughness of the nanomaterial as is reported by Chen et al .…”

Section: Discussionmentioning

confidence: 99%

Nanochips of Tantalum Oxide Nanodots as artificial-microenvironments for monitoring Ovarian cancer progressiveness

Dhawan

Wang

Chu

et al. 2016

Sci Rep

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Nanotopography modulates cell characteristics and cell behavior. Nanotopological cues can be exploited to investigate the in-vivo modulation of cell characteristics by the cellular microenvironment. However, the studies explaining the modulation of tumor cell characteristics and identifying the transition step in cancer progressiveness are scarce. Here, we engineered nanochips comprising of Tantalum oxide nanodot arrays of 10, 50, 100 and 200 nm as artificial microenvironments to study the modulation of cancer cell behavior. Clinical samples of different types of Ovarian cancer at different stages were obtained, primary cultures were established and then seeded on different nanochips. Immunofluorescence (IF) was performed to compare the morphologies and cell characteristics. Indices corresponding to cell characteristics were defined. A statistical comparison of the cell characteristics in response to the nanochips was performed. The cells displayed differential growth parameters. Morphology, Viability, focal adhesions, microfilament bundles and cell area were modulated by the nanochips which can be used as a measure to study the cancer progressiveness. The ease of fabrication of nanochips ensures mass-production. The ability of the nanochips to act as artificial microenvironments and modulate cell behavior may lead to further prospects in the markerless monitoring of the progressiveness and ultimately, improving the prognosis of Ovarian cancer.

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“…This could be due to a delay in lymphatic drainage due to the previous surgery. Over the whole study term, all beads remained inert in the tissue as expected [39,40], with no migration out of the tendon tissue occurring. It is assumed that migration could potentially occur within the first six weeks after implantation [41].…”

Section: Clinical Examinationmentioning

confidence: 65%

Biplanar High-Speed Fluoroscopy of Pony Superficial Digital Flexor Tendon (SDFT)—An In Vivo Pilot Study

Wagner

Gerlach

Geiger

et al. 2021

Veterinary Sciences

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The superficial digital flexor tendon (SDFT) is the most frequently injured structure of the musculoskeletal system in sport horses and a common cause for early retirement. This project’s aim was to visualize and measure the strain of the sound, injured, and healing SDFTs in a pony during walk and trot. For this purpose, biplanar high-speed fluoroscopic kinematography (FluoKin), as a high precision X-ray movement analysis tool, was used for the first time in vivo with equine tendons. The strain in the metacarpal region of the sound SDFT was 2.86% during walk and 6.78% during trot. When injured, the strain increased to 3.38% during walk and decreased to 5.96% during trot. The baseline strain in the mid-metacarpal region was 3.13% during walk and 6.06% during trot and, when injured, decreased to 2.98% and increased to 7.61%, respectively. Following tendon injury, the mid-metacarpal region contributed less to the overall strain during walk but showed increased contribution during trot. Using this marker-based FluoKin technique, direct, high-precision, and long-term strain measurements in the same individual are possible. We conclude that FluoKin is a powerful tool for gaining deeper insight into equine tendon biomechanics.

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Tantalum markers in radiography

Cited by 34 publications

References 11 publications

Spatial Control of Cell-Nanosurface Interactions by Tantalum Oxide Nanodots for Improved Implant Geometry

Spatial Control of Cell-Nanosurface Interactions by Tantalum Oxide Nanodots for Improved Implant Geometry

Nanochips of Tantalum Oxide Nanodots as artificial-microenvironments for monitoring Ovarian cancer progressiveness

Biplanar High-Speed Fluoroscopy of Pony Superficial Digital Flexor Tendon (SDFT)—An In Vivo Pilot Study

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