Tapping into Deep-Water Reservoirs to Overcome Antibiotic Resistance through Bacteria-Producing Unique Secondary Metabolites

doi:10.4172/2153-2435.1000e172

Pharm Anal Acta

2015

DOI: 10.4172/2153-2435.1000e172

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Tapping into Deep-Water Reservoirs to Overcome Antibiotic Resistance through Bacteria-Producing Unique Secondary Metabolites

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2020

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Ecological and Industrial Implications of Dynamic Seaweed-Associated Microbiota Interactions

Menaa

Wijesinghe²,

Thiripuranathar³

et al. 2020

Marine Drugs

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Seaweeds are broadly distributed and represent an important source of secondary metabolites (e.g., halogenated compounds, polyphenols) eliciting various pharmacological activities and playing a relevant ecological role in the anti-epibiosis. Importantly, host (as known as basibiont such as algae)–microbe (as known as epibiont such as bacteria) interaction (as known as halobiont) is a driving force for coevolution in the marine environment. Nevertheless, halobionts may be fundamental (harmless) or detrimental (harmful) to the functioning of the host. In addition to biotic factors, abiotic factors (e.g., pH, salinity, temperature, nutrients) regulate halobionts. Spatiotemporal and functional exploration of such dynamic interactions appear crucial. Indeed, environmental stress in a constantly changing ocean may disturb complex mutualistic relations, through mechanisms involving host chemical defense strategies (e.g., secretion of secondary metabolites and antifouling chemicals by quorum sensing). It is worth mentioning that many of bioactive compounds, such as terpenoids, previously attributed to macroalgae are in fact produced or metabolized by their associated microorganisms (e.g., bacteria, fungi, viruses, parasites). Eventually, recent metagenomics analyses suggest that microbes may have acquired seaweed associated genes because of increased seaweed in diets. This article retrospectively reviews pertinent studies on the spatiotemporal and functional seaweed-associated microbiota interactions which can lead to the production of bioactive compounds with high antifouling, theranostic, and biotechnological potential.

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Ecological and Industrial Implications of Dynamic Seaweed-Associated Microbiota Interactions

Menaa

Wijesinghe²,

Thiripuranathar³

et al. 2020

Marine Drugs

View full text Add to dashboard Cite

show abstract

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Tapping into Deep-Water Reservoirs to Overcome Antibiotic Resistance through Bacteria-Producing Unique Secondary Metabolites

Cited by 1 publication

References 7 publications

Ecological and Industrial Implications of Dynamic Seaweed-Associated Microbiota Interactions

Ecological and Industrial Implications of Dynamic Seaweed-Associated Microbiota Interactions

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