Tapping into the Influence of Keratinocyte Allografts and Biocenosis on Healing of Chronic Leg Ulcers: Split-Ulcer Controlled Pilot Study

Abstract

In this small case series, it appears that cultured allogeneic keratinocytes may be helpful in the healing process of venous leg ulcers. However, a clean wound with reduced bacterial load seems to be the prerequisite condition for obtaining a beneficial effect.

Healing effect of ketanserin on chronic leg ulcers in patients with diabetes

“…Impaired healing is due, among others, to primary microvascular changes following venous hypertension. The situation is aggravated by diabetes and, in some cases, by intercurrent bacteria‐driven vasculitis 2,9–11 . The major problem in evaluating therapy of leg ulcers is the lack of standardized parameters to assess healing.…”

“…The situation is aggravated by diabetes and, in some cases, by intercurrent bacteria-driven vasculitis. 2,[9][10][11] The major problem in evaluating therapy of leg ulcers is the lack of standardized parameters to assess healing. Moreover, the initial ulcer size usually varies greatly from patient to patient.…”

“…Hence, phase II evaluations of therapy may benefit from a reasonable, predetermined time interval to use as a benchmark rather than considering complete healing as the end point. Rates of healing relative to the various sizes and shapes of the ulcers are also worth considering 5–10 …”

“…Rates of healing relative to the various sizes and shapes of the ulcers are also worth considering. [5][6][7][8][9][10] The aim of the present study was to revisit the effect of topical 2% ketanserin ointment on the healing rate of chronic leg ulcers present in patients with diabetes with venous insufficiency.…”

Umbilical-cord-derived Mesenchymal Stem Cell Transplantation Ameliorated Severe Leg Ulcers in a Patient with Rheumatoid Arthritis: A Case Report and Review of the Literature

“…Established therapies, including glucocorticoid and immunosuppressive agents can take a long time to heal the wounds and, additionally, not all patients respond well to these treatments [1]. In recent years, endothelial progenitor cells (EPCs) [2], bone-marrow-derived mononuclear cells (BM-MNCs) [3], fibrocytes [4] and karotinocytes [5] have been shown to be helpful in the healing process of leg ulcers. In a rat diabetic wound healing model, systemic and local treatment with bone-marrow-derived mesenchymal stem cells (BM-MSCs) also demonstrated efficacy [6].…”