Target delivery of doxorubicin tethered with PVP stabilized gold nanoparticles for effective treatment of lung cancer

Ramalingam, Vaikundamoorthy; Varunkumar, Krishnamoorthy; Ravikumar, Vasulinga T.; Rajendran, R.

doi:10.1038/s41598-018-22172-5

Cited by 142 publications

(63 citation statements)

References 58 publications

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“…Doxorubicin was selected to evaluate the ability of these nanoparticles to encapsulate bioactive substances. DOX, an antibiotic of the anthracycline family, is a front‐line drug used clinically to treat different tumors such as liver or lung cancer . However, DOX has a narrow therapeutic index for clinical use because of its side effects, such as cardiotoxicity and myelosuppression.…”

Section: Resultsmentioning

confidence: 99%

Temperature stimuli‐responsive nanoparticles from chitosan‐graft‐poly(N‐vinylcaprolactam) as a drug delivery system

Fernández‐Quiroz

Loya‐Duarte

Silva‐Campa

et al. 2019

J of Applied Polymer Sci

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This work describes the preparation of thermosensitive chitosan‐graft‐poly(N‐vinylcaprolactam) nanoparticles by ionic gelation and their potential use as a controlled drug delivery system, using doxorubicin as a model drug. A systematic study of the effect of the main processing parameters on both the size and thermoresponsive behavior of nanoparticles was investigated. The size of the particles is strongly dependent on the length of the poly(N‐vinylcaprolactam) grafted chains and the concentration of the copolymer and crosslinking agent solutions. The molecular structure of the copolymer plays an essential role in the phase transition temperature of the particles, which decreases with the length of PVCL grafted chain. The system displayed proper drug‐association parameters, and the drug‐loaded nanoparticles exhibited dose‐dependent cytotoxicity. A significant increase in the doxorubicin delivery rate was observed above the phase transition temperature (40 °C). These features indicate that these nanoparticles are suitable for the development of a new thermally controlled anti‐cancer drug delivery system. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47831.

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Section: Resultsmentioning

confidence: 99%

Temperature stimuli‐responsive nanoparticles from chitosan‐graft‐poly(N‐vinylcaprolactam) as a drug delivery system

Fernández‐Quiroz

Loya‐Duarte

Silva‐Campa

et al. 2019

J of Applied Polymer Sci

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“…1C, D). This result suggested that the size of GRs have increased up to around 100 nm by conjugation of resveratrol to GNPs via PVP [19,20]. Gangwar et al described that curcumin was conjugated via PVP to gold nanoparticle through intermolecular hydrogen bonding to enolic hydroxyl group [19].…”

Section: Gnps Synthesismentioning

confidence: 97%

Gold nanoparticles conjugated with resveratrol induce cell cycle arrest in MCF-7 cell lines

Lee

et al. 2019

Appl Biol Chem

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Resveratrol is a kind of phytoalexin produced in several plants with self-defense effect. It is known for its anti-inflammatory and ant-cancer effects. However, it has low efficacy due to its degradation before reaching the target. To heighten its delivery rate and efficacy, gold nanoparticles (GNPs) under 30 nm size were synthesized as drug carrier and conjugated with resveratrol via polyvinylpyrrolidone (PVP) as cross-linker. These gold nanoparticles conjugated with resveratrol (GRs) were used to estimate their anti-tumor effects through cell cycle arrest. It was found that resveratrol-and GRs-treated groups had decreased extent of G0/G1 phase but increased extent of S phase compared to control and GNP-treated groups, suggesting that the effect was due to resveratrol which was attached to gold nanoparticles. To estimate cytotoxicity after treatment with GNPs and GRs, the extent of lactate dehydrogenase (LDH) release was investigated. Results showed that GNPs and GRs-treated groups had almost no difference in LDH release compared to control group, suggesting that the extent of toxicity was not significant. Taken together, these results suggest that GRs could be potentially effective in treating cancer as anti-tumor drug with further development.

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“…In addition, DOX@PVP-Au-NPs highly upregulated tumor suppressor gene expression compared with DOX and PVP-Au-NPs and induced intrinsic apoptosis in lung cancer cells. 55 DOX shows a cumulative dose-dependent side effect of cardiotoxicity. Du et al designed an Au-NP-based DDS to solve this problem.…”

Section: Dox Delivery By Au-npsmentioning

confidence: 99%

<p>A review of small molecules and drug delivery applications using gold and iron nanoparticles</p>

Jahangirian¹,

Kalantari²,

Izadiyan³

et al. 2019

IJN

177

106

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Conventional cancer treatment techniques show several limitations including low or no specificity and consequently a low efficacy in discriminating between cancer cells and healthy cells. Recent nanotechnology developments have introduced smart and novel therapeutic nanomaterials that take advantage of various targeting approaches. The use of nanotechnology in medicine and, more specifically, drug delivery is set to spread even more rapidly than it has over the past two decades. Currently, many nanoparticles (NPs) are under investigation for drug delivery including those for cancer therapy. Targeted nanomaterials bind selectively to cancer cells and greatly affect them with only a minor effect on healthy cells. Gold nanoparticles (Au-NPs), specifically, have been identified as significant candidates for new cancer therapeutic modalities because of their biocompatibility, easy functionalization and fabrication, optical tunable characteristics, and chemophysical stability. In the last decade, there has been significant research on Au-NPs and their biomedical applications. Functionalized Au-NPs represent highly attractive and promising candidates for drug delivery, owing to their unique dimensions, tunable surface functionalities, and controllable drug release. Further, iron oxide NPs due to their "superparamagnetic" properties have been studied and have demonstrated successful employment in numerous applications. In targeted drug delivery systems, drug-loaded iron oxide NPs can accumulate at the tumor site with the aid of an external magnetic field. This can lead to incremental effectiveness in drug release to the tumor site and vanquish cancer cells without harming healthy cells. In order for the application of iron oxide NPs in the human body to be realized, they should be biodegradable and biocompatible to minimize toxicity. This review illustrates recent advances in the field drug and small molecule delivery such as fluorouracil, folic acid, doxorubicin, paclitaxel, and daunorubicin, specifically when using gold and iron oxide NPs as carriers of anticancer therapeutic agents.

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Target delivery of doxorubicin tethered with PVP stabilized gold nanoparticles for effective treatment of lung cancer

Cited by 142 publications

References 58 publications

Temperature stimuli‐responsive nanoparticles from chitosan‐graft‐poly(N‐vinylcaprolactam) as a drug delivery system

Temperature stimuli‐responsive nanoparticles from chitosan‐graft‐poly(N‐vinylcaprolactam) as a drug delivery system

Gold nanoparticles conjugated with resveratrol induce cell cycle arrest in MCF-7 cell lines

<p>A review of small molecules and drug delivery applications using gold and iron nanoparticles</p>

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