Target delivery selective CSF-1R inhibitor to tumor-associated macrophages via erythrocyte-cancer cell hybrid membrane camouflaged pH-responsive copolymer micelle for cancer immunotherapy

Wang, Yuchi; Luan, Zhiyong; Zhao, Chaoyue; Chen, Bai; Yang, Kunlong

doi:10.1016/j.ejps.2019.105136

Cited by 77 publications

(50 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…NPs wrapped with membranes that are harvested from a patient's own cancer cells homotypically adhere to patient-derived cancer cell lines; mismatch between the donor and host results in weak targeting 196,197 . NPs wrapped with macrophage or leukocyte membranes recognize tumours, and hybrid membranes, such as erythrocyte-cancer cell hybrids, can further increase specificity [197][198][199] . NPs that utilize these membranes show a twofold to threefold increase in drug activity over the free drug 198 .…”

Section: Nps For Cancer Therapymentioning

confidence: 99%

“…NPs wrapped with macrophage or leukocyte membranes recognize tumours, and hybrid membranes, such as erythrocyte-cancer cell hybrids, can further increase specificity [197][198][199] . NPs that utilize these membranes show a twofold to threefold increase in drug activity over the free drug 198 . In a similar fashion, material properties can cause NPs to preferentially distribute to certain tissues.…”

Section: Nps For Cancer Therapymentioning

confidence: 99%

“…Mannose is commonly used to target macrophages and tumour-associated macrophages [238][239][240] , but can target dendritic cells as well 241 . Particles coated with galactose, dextran or sialoadhesin can deliver to macrophages 198,240,242 . CD19-targeting NPs can be used to actively target B cells 243 , and NPs with lipoprotein surfaces can activate the scavenger receptor class B1 (SRB1) receptor on dendritic cells 244 .…”

Section: Nps For Immunotherapymentioning

confidence: 99%

See 2 more Smart Citations

Engineering precision nanoparticles for drug delivery

Mitchell

Billingsley

Haley

et al. 2020

Nat Rev Drug Discov

4,510

2,814

View full text Add to dashboard Cite

In recent years, the development of nanoparticles has expanded into a broad range of clinical applications. Nanoparticles have been developed to overcome the limitations of free therapeutics and navigate biological barriers — systemic, microenvironmental and cellular — that are heterogeneous across patient populations and diseases. Overcoming this patient heterogeneity has also been accomplished through precision therapeutics, in which personalized interventions have enhanced therapeutic efficacy. However, nanoparticle development continues to focus on optimizing delivery platforms with a one-size-fits-all solution. As lipid-based, polymeric and inorganic nanoparticles are engineered in increasingly specified ways, they can begin to be optimized for drug delivery in a more personalized manner, entering the era of precision medicine. In this Review, we discuss advanced nanoparticle designs utilized in both non-personalized and precision applications that could be applied to improve precision therapies. We focus on advances in nanoparticle design that overcome heterogeneous barriers to delivery, arguing that intelligent nanoparticle design can improve efficacy in general delivery applications while enabling tailored designs for precision applications, thereby ultimately improving patient outcome overall.

show abstract

Section: Nps For Cancer Therapymentioning

confidence: 99%

Section: Nps For Cancer Therapymentioning

confidence: 99%

Section: Nps For Immunotherapymentioning

confidence: 99%

See 1 more Smart Citation

Engineering precision nanoparticles for drug delivery

Mitchell

Billingsley

Haley

et al. 2020

Nat Rev Drug Discov

4,510

2,814

View full text Add to dashboard Cite

show abstract

“…An association constant is signicantly related to the Gibb's free energy. 32,33 Hence, Gibb's free energy changes, DG, for complexation can be obtained for such complexation using K a according to eqn (2).…”

Section: Thermodynamics Of Bindingmentioning

confidence: 99%

“…In the last few decades, targeted drug delivery has become a crucial issue in the bio-medical eld as it provides the undeniable advantage of minimizing the associated aer-effects of drugs like psychotic illness, overstimulation and other dysfunctions. 1,2 Generally, drugs interact with surfactants, ionic liquids (ILs), cyclodextrins and other carriers to promote their controlled and specic delivery. [3][4][5] Earlier ILs were recognized only as better alternatives to volatile organic solvents with superior properties.…”

Section: Introductionmentioning

confidence: 99%

Multi-spectroscopic monitoring of molecular interactions between an amino acid-functionalized ionic liquid and potential anti-Alzheimer's drugs

et al. 2020

View full text Add to dashboard Cite

show abstract

Cell Membrane Coated Particles

Spanjers

Städler

2020

Adv. Biosys.

View full text Add to dashboard Cite

that red blood cells (RBCs) circulate over 100 days although they are larger than the smallest capillaries. Nature not only employs the surface chemistry of the cells, but also their geometry and mechanical properties, i.e., the biconcave shape of the RBCs, give them the deformability to pass capillaries. Therefore, efforts to mimic RBCs are being reported from fabricating geometrically matching entities to matching their chemical composition. [2] However, making an artificial copy of a cell is challenging. Hence, the compromise between relying on a single interaction point (typically receptor-antibody interactions) of nanoformulations with cells and tissue, and the great complexity of an entire cell is currently a more realistic approach. An interesting example in this context is the use of purified cell membrane to camouflage (nano)particles. This concept offers opportunity to mimic cell−cell interactions employing multiple types of contact points while avoiding the need to obtain/purify specific proteins. This nature-inspired approach was first shown in 2011 with RBC membranes to enhance particle blood circulation times and developed in the next 4-5 years to include white blood cells, platelets, and cancerous cell sources. [3] The field gained increasing attention over the past years, expanding on types of cell sources, coated particles, and envisioned applications. This progress report will highlight selected efforts in the field from the past 2-3 years focusing on mammalian cell sources and coating of colloidal systems (Scheme 1). Efforts pre-dating 2017/2018 were already discussed in detail in several reviews. [4] First, a short overview over the general cell membrane purification procedure and subsequent characterization will be provided. Then, we will outline advances made when non-nuclei or nuclei containing cells sources were used. Finally, coatings consisting of two types of cell membrane (hybrid coatings) will be discussed 2. Formation and Characterization of Cell Membrane Coated Particles Despite of the variation in cell sources, the general purification methods of cell membranes and sequential coating of particles are rather similar and therefore described only briefly. Furthermore, important characterization techniques for size, protein content, and surface charge are discussed. We would like to note that there are a variety of other techniques not mentioned here specifically that can provide valuable specific information such as Fourier transform infrared spectroscopy for analysis of Nanoformulations are widely considered in the biomedical field for drug delivery, imaging, or detoxification purposes. Cell membrane coatings are a growing concept that aims to camouflage nanomaterials. The cell membranes are the first point of contact for cells to other biological or synthetic materials and nature has established signaling pathways in this context. In contrast to using purified membrane associated proteins, the use of purified cell membranes contains the protein of interest in a very native environme...

show abstract

Target delivery selective CSF-1R inhibitor to tumor-associated macrophages via erythrocyte-cancer cell hybrid membrane camouflaged pH-responsive copolymer micelle for cancer immunotherapy

Cited by 77 publications

References 55 publications

Engineering precision nanoparticles for drug delivery

Engineering precision nanoparticles for drug delivery

Multi-spectroscopic monitoring of molecular interactions between an amino acid-functionalized ionic liquid and potential anti-Alzheimer's drugs

Cell Membrane Coated Particles

Contact Info

Product

Resources

About