Target Development for Medical Radionuclides Cu-67 and Sr-82 Production

Abstract

Abstract. At PNPI NRC KI (Petersburg Nuclear Physics Institute of National Research Center "Kurchatov Institute"), a high current cyclotron C-80 has been put into operation recently. External proton beam of the energy of 70 MeV and intensity of 100 μA has been obtained. Presently, the work is being carried out to obtain the planned beam parameters: the energy up to 80 MeV and the current up to 200 μA. The main goal of the C-80 is the production of medical radionuclides for diagnostics and therapy. One of the cyclotron beams is intended for the treatment of ophthalmologic diseases by irradiation of malignant eye formation. The radioisotope complex RIC-80 (Radioactive Isotopes at cyclotron C-80) which is constructed at the beam of C-80 will allow us to obtain sources of high activity practically for the whole list of radionuclides produced at accelerators. An essential peculiarity of the RIC-80 is the use of an on-line mass-separator connected to one of the target stations that will allow the production of separated radionuclides of high purity. The target prototypes intended for the production of different radionuclides at the RIC-80 target stations are being studied and developed. The results of different target material tests for the production of 67 Cu, 82 Sr and other radioisotopes are presented. A new method of a high-temperature separation of the target materials and produced radioactive isotopes has been discussed.

Development of High Temperature and Mass-Separation Methods for Selective Production of Medical Radionuclides

“…It is confirmed as well for the couple ytterbium -lutetium with their boiling points of 1194 °C and 3393 °C. In the first tests, a high-temperature method of separation of 171, 172 Lu from the ytterbium metal target, similar to that described in [15] for copper metal target, has been utilized. In the present work, the ytterbium metal target was irradiated during 24 h by the proton beam of the PNPI synchrocyclotron with the proton energy of 100 MeV.…”

Новый метод получения генераторного радионуклида Sr-82 и других медицинских радионуклидов

“…1. Величины энергий адсорбции для атомов различных элементов на поверхностях тугоплавких металлов -молибдена, ниобия и тантала [9].…”

“…Радионуклид 82 Sr с периодом полураспада T 1/2 = 25.55 d является генератором его дочернего изотопа 82 Rb (T 1/2 = 1.25 min), который широко используется в ПЭТ диагностике. Для разделения мишенного материала и образованных в нем в качестве продуктов реакций изотопов стронция использовался новый метод " сухого", высокотемпературного выделения [8,9]…”

NEW METHOD DEVELOPMENT FOR MEDICAL RADIONUCLIDE 223,224Ra, 225Ac PRODUCTION

“…The mass-separator method will make it possible to produce very pure beams of some radioisotopes. In this paper, the results of the experiments, making use of a new method [4] of a high temperature release and mass-separation of 223,224 Ra and 225 Ac from 238 UC (uranium mono-carbide of a high density) as a target material, are presented. Pharmaceuticals produced on the base of these alphaemitting radionuclides are of great importance for malignant tumors treatment at a very early stage of their appearance.…”