“…Computational approaches have been investigated as a means to predict the synergistic interaction of compounds previously, with methods that utilize networks of pathways and simulation (Lehár et al, 2007 ; Nelander et al, 2008 ; Miller et al, 2013 ; Huang et al, 2014 ; Patel et al, 2014 ; Zhang et al, 2014 ), relationships between physicochemical properties (Yilancioglu et al, 2014 ), chemogenomics approaches (Bansal et al, 2014 ; Wildenhain et al, 2015 ; KalantarMotamedi et al, 2018 ), and single agent efficacies (Gayvert et al, 2017 ) and/or combinations (Menden et al, 2018 ) measured across multiple cell lines (for recent reviews of compound combination modeling and perspectives, see Bulusu et al, 2016 ; Weinstein et al, 2017 ; Tsigelny, 2018 ). A disadvantage to many of these approaches is that they often require experimental knowledge of underlying biological interactions between drugs and disease, or chemogenomic or phenotypic readouts (Jansen et al, 2009 ; Bansal et al, 2014 ; Wildenhain et al, 2015 ; Menden et al, 2018 ).…”