Target of rapamycin signaling is tightly and differently regulated in the plant response under distinct abiotic stresses

Pereyra, Cintia M.; Aznar, Néstor R; Rodriguez, Marianela; Salerno, Graciela L.; Martínez-Noël, Giselle

doi:10.1007/s00425-019-03305-0

Cited by 30 publications

(20 citation statements)

References 64 publications

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“…In addition to nutrients and hormones, unfavorable environmental cues, such as abiotic stresses (cold, osmatic stress, salt, and oxidative stress), and biotic stresses (virus infection), have been reported to be either the inhibitory or activation signals for TOR kinase in plants (Figure 3F) (Mahfouz et al, 2006;Schepetilnikov et al, 2011;Wang et al, 2017Wang et al, 2018aPooggin and Ryabova, 2018;Ahn et al, 2019;Dong et al, 2019;Pereyra et al, 2019;Sharma et al, 2019).…”

Section: Abiotic and Biotic Stressesmentioning

confidence: 99%

Plant target of rapamycin signaling network: Complexes, conservations, and specificities

Liu

Xiong

2022

JIPB

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Target of rapamycin (TOR) is an evolutionarily conserved protein kinase that functions as a central signaling hub to integrate diverse internal and external cues to precisely orchestrate cellular and organismal physiology. During evolution, TOR both maintains the highly conserved TOR complex compositions, and cellular and molecular functions, but also evolves distinctive roles and strategies to modulate cell growth, proliferation, metabolism, survival, and stress responses in eukaryotes. Here, we review recent discoveries on the plant TOR signaling network. We present an overview of plant TOR complexes, analyze the signaling landscape of the plant TOR signaling network from the upstream signals that regulate plant TOR activation to the downstream effectors involved in various biological processes, and compare their conservation and specificities within different biological contexts. Finally, we summarize the impact of dysregulation of TOR signaling on every stage of plant growth and development, from embryogenesis and seedling growth, to flowering and senescence.

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Section: Abiotic and Biotic Stressesmentioning

confidence: 99%

Plant target of rapamycin signaling network: Complexes, conservations, and specificities

Liu

Xiong

2022

JIPB

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“…Although trying to understand TOR signaling with respect to a single stimulus has been the order of the day [237][238][239], it goes without saying that in the real outside environment, plants experience multiple stimuli, which may not be achieved in the laboratory setting in which most experiments are done. For instance, plants usually face a combination of saline, extreme heat or reduced water availability conditions, but how these external stimuli are sensed and integrated as a set is understudied.…”

Section: Perspectivesmentioning

confidence: 99%

“…For instance, plants usually face a combination of saline, extreme heat or reduced water availability conditions, but how these external stimuli are sensed and integrated as a set is understudied. Moreover, it is probable that TOR, a master signal integrator, contributes significantly to plant survival when faced with multiple stresses, although more experimental evidence is needed [239]. For instance, consistent with stress-specific tissue-or cell-specific plant responses, TORC1 may mediate responses specific to a combination of stresses or stimuli to ensure acclimation [239][240][241] by regulating processes such as autophagy in a context-specific manner.…”

Section: Perspectivesmentioning

confidence: 99%

“…Moreover, it is probable that TOR, a master signal integrator, contributes significantly to plant survival when faced with multiple stresses, although more experimental evidence is needed [239]. For instance, consistent with stress-specific tissue-or cell-specific plant responses, TORC1 may mediate responses specific to a combination of stresses or stimuli to ensure acclimation [239][240][241] by regulating processes such as autophagy in a context-specific manner. Whether this regulation is achieved post transcriptionally or at a protein level will be an interesting question to pursue further.…”

Section: Perspectivesmentioning

confidence: 99%

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Target of Rapamycin in Control of Autophagy: Puppet Master and Signal Integrator

Mugume

Kazibwe

Bassham

2020

IJMS

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The target of rapamycin (TOR) is an evolutionarily-conserved serine/threonine kinase that senses and integrates signals from the environment to coordinate developmental and metabolic processes. TOR senses nutrients, hormones, metabolites, and stress signals to promote cell and organ growth when conditions are favorable. However, TOR is inhibited when conditions are unfavorable, promoting catabolic processes such as autophagy. Autophagy is a macromolecular degradation pathway by which cells degrade and recycle cytoplasmic materials. TOR negatively regulates autophagy through phosphorylation of ATG13, preventing activation of the autophagy-initiating ATG1-ATG13 kinase complex. Here we review TOR complex composition and function in photosynthetic and non-photosynthetic organisms. We also review recent developments in the identification of upstream TOR activators and downstream effectors of TOR. Finally, we discuss recent developments in our understanding of the regulation of autophagy by TOR in photosynthetic organisms.

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“…SnRK1 inactivates TOR through phosphorylation of its RAPTOR subunits, and several evidences suggested a reciprocal regulation of SnRK1 by TOR [88]. Recent study reported that abiotic stresses, such as salt, cold and osmotic stresses, regulate TOR complex transcript levels and activity [90]. In our experiment, expression of genes encoding TOR (AT1G50030), RAPTOR3G (AT3G08850) and the SnRK1 catalytic (AT3G01090 and AT3G29160) subunits were induced by N starvation, while other (regulatory) subunits of the complexes were repressed in cytolines compared to parents (Figure 9).…”

Section: Disruption Of Cyto-nuclear Coadaptation Modulated the Transcmentioning

confidence: 99%

The Consequences of a Disruption in Cyto-Nuclear Coadaptation on the Molecular Response to a Nitrate Starvation in Arabidopsis

Chardon

Cueff

Delannoy

et al. 2020

Plants

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Mitochondria and chloroplasts are important actors in the plant nutritional efficiency. So, it could be expected that a disruption of the coadaptation between nuclear and organellar genomes impact plant response to nutrient stresses. We addressed this issue using two Arabidopsis accessions, namely Ct-1 and Jea, and their reciprocal cytolines possessing the nuclear genome from one parent and the organellar genomes of the other one. We measured gene expression, and quantified proteins and metabolites under N starvation and non-limiting conditions. We observed a typical response to N starvation at the phenotype and molecular levels. The phenotypical response to N starvation was similar in the cytolines compared to the parents. However, we observed an effect of the disruption of genomic coadaptation at the molecular levels, distinct from the previously described responses to organellar stresses. Strikingly, genes differentially expressed in cytolines compared to parents were mainly repressed in the cytolines. These genes encoded more mitochondrial and nuclear proteins than randomly expected, while N starvation responsive ones were enriched in genes for chloroplast and nuclear proteins. In cytolines, the non-coadapted cytonuclear genomic combination tends to modulate the response to N starvation observed in the parental lines on various biological processes.

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Target of rapamycin signaling is tightly and differently regulated in the plant response under distinct abiotic stresses

Cited by 30 publications

References 64 publications

Plant target of rapamycin signaling network: Complexes, conservations, and specificities

Plant target of rapamycin signaling network: Complexes, conservations, and specificities

Target of Rapamycin in Control of Autophagy: Puppet Master and Signal Integrator

The Consequences of a Disruption in Cyto-Nuclear Coadaptation on the Molecular Response to a Nitrate Starvation in Arabidopsis

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