TARGET OF RAPAMYCIN signaling plays a role in Arabidopsis growth promotion by Azospirillum brasilense Sp245

Méndez-Gómez, Manuel; Castro-Mercado, Elda; Peña-Uribe, César Arturo; López‐Bucio, José; García-Pineda, Ernesto

doi:10.1016/j.plantsci.2020.110416

Cited by 21 publications

(18 citation statements)

References 46 publications

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“…Since elucidation of the important role of mTOR in tumorigenesis and progression, it is now being studied as a tumour suppressor. Rapamycin binds to the immunosuppressive protein fkbp-12 to form an immunosuppressive complex, inhibiting the transition of mTOR and G1 to S phase transition [79]. RAD001, also known as everolimus, is a novel rapamycin derivative similar to a mTOR inhibitor that inhibits mTORC1 but has no effect on mTORC2 [80].…”

Section: Mtor Inhibitorsmentioning

confidence: 99%

RETRACTED ARTICLE: Roles of the PI3K/AKT/mTOR signalling pathways in neurodegenerative diseases and tumours

et al. 2020

Cell Biosci

469

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The PI3 K/AKT/mTOR signalling pathway plays an important role in the regulation of signal transduction and biological processes such as cell proliferation, apoptosis, metabolism and angiogenesis. Compared with those of other signalling pathways, the components of the PI3K/AKT/mTOR signalling pathway are complicated. The regulatory mechanisms and biological functions of the PI3K/AKT/mTOR signalling pathway are important in many human diseases, including ischaemic brain injury, neurodegenerative diseases, and tumours. PI3K/AKT/mTOR signalling pathway inhibitors include single-component and dual inhibitors. Numerous PI3K inhibitors have exhibited good results in preclinical studies, and some have been clinically tested in haematologic malignancies and solid tumours. In this review, we briefly summarize the results of research on the PI3K/AKT/mTOR pathway and discuss the structural composition, activation, communication processes, regulatory mechanisms and biological functions of the PI3K/AKT/mTOR signalling pathway in the pathogenesis of neurodegenerative diseases and tumours.

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Section: Mtor Inhibitorsmentioning

confidence: 99%

RETRACTED ARTICLE: Roles of the PI3K/AKT/mTOR signalling pathways in neurodegenerative diseases and tumours

et al. 2020

Cell Biosci

469

263

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“…Similarly, according to numerous studies ( Table 2 ), the improvement in agronomic yields by PGPR (or PGPR-based biostimulants) is due to the production of growth-stimulating phytohormones such as indole-3-acetic acid (IAA), zeatin, ABA, ET and gibberellic acid (GA), secondary metabolites (siderophores, lipopeptides and N-acyl homoserine lactone) and volatile organic compounds (hydrogen cyanide, acetoin and 2,3 butanediol). Most recently, it has been demonstrated that Azospirillum brasilense Sp245 lipopolysaccharides (LPS) stimulate growth (fresh weight and root length) in Arabidopsis thaliana [ 130 ] and this further suggest that PGPR-derived MAMPs also play a role in plant growth stimulation.…”

Section: Microbial Biostimulants and Enhancement Of Plant Responses To Abiotic Stressesmentioning

confidence: 99%

Plant Responses to Abiotic Stresses and Rhizobacterial Biostimulants: Metabolomics and Epigenetics Perspectives

et al. 2021

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In response to abiotic stresses, plants mount comprehensive stress-specific responses which mediate signal transduction cascades, transcription of relevant responsive genes and the accumulation of numerous different stress-specific transcripts and metabolites, as well as coordinated stress-specific biochemical and physiological readjustments. These natural mechanisms employed by plants are however not always sufficient to ensure plant survival under abiotic stress conditions. Biostimulants such as plant growth-promoting rhizobacteria (PGPR) formulation are emerging as novel strategies for improving crop quality, yield and resilience against adverse environmental conditions. However, to successfully formulate these microbial-based biostimulants and design efficient application programs, the understanding of molecular and physiological mechanisms that govern biostimulant-plant interactions is imperatively required. Systems biology approaches, such as metabolomics, can unravel insights on the complex network of plant-PGPR interactions allowing for the identification of molecular targets responsible for improved growth and crop quality. Thus, this review highlights the current models on plant defence responses to abiotic stresses, from perception to the activation of cellular and molecular events. It further highlights the current knowledge on the application of microbial biostimulants and the use of epigenetics and metabolomics approaches to elucidate mechanisms of action of microbial biostimulants.

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“…The temporal dynamics of TORC inhibition mediated by the chemical AZD8055, extensively employed to investigate the TOR pathway in plants (Montané and Menand, 2013;Dong et al, 2015;Ouibrahim et al, 2015;Dobrenel et al, 2016b;Prioretti et al, 2017;Schepetilnikov et al, 2017;Soprano et al, 2017;Inaba and Nagy, 2018;Mohammed et al, 2018;Riegler et al, 2018;Barrada et al, 2019;Forzani et al, 2019;Song et al, 2019;Van Leene et al, 2019;Méndez-Gómez et al, 2020;Zhu et al, 2020), was followed in seedlings of S. viridis and A. thaliana at specific and compatible developmental stages. Dose-dependent experiments, using the root GI 50 as a parameter (Figure 2), revealed that growth arrest is a phenotypic consequence of TORC repression in both species.…”

Section: Discussionmentioning

confidence: 99%

Shedding Light on the Dynamic Role of the “Target of Rapamycin” Kinase in the Fast-Growing C4 Species Setaria viridis, a Suitable Model for Biomass Crops

et al. 2021

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The Target of Rapamycin (TOR) kinase pathway integrates energy and nutrient availability into metabolism promoting growth in eukaryotes. The overall higher efficiency on nutrient use translated into faster growth rates in C4 grass plants led to the investigation of differential transcriptional and metabolic responses to short-term chemical TOR complex (TORC) suppression in the model Setaria viridis. In addition to previously described responses to TORC inhibition (i.e., general growth arrest, translational repression, and primary metabolism reprogramming) in Arabidopsis thaliana (C3), the magnitude of changes was smaller in S. viridis, particularly regarding nutrient use efficiency and C allocation and partitioning that promote biosynthetic growth. Besides photosynthetic differences, S. viridis and A. thaliana present several specificities that classify them into distinct lineages, which also contribute to the observed alterations mediated by TOR. Indeed, cell wall metabolism seems to be distinctly regulated according to each cell wall type, as synthesis of non-pectic polysaccharides were affected in S. viridis, whilst assembly and structure in A. thaliana. Our results indicate that the metabolic network needed to achieve faster growth seems to be less stringently controlled by TORC in S. viridis.

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TARGET OF RAPAMYCIN signaling plays a role in Arabidopsis growth promotion by Azospirillum brasilense Sp245

Cited by 21 publications

References 46 publications

RETRACTED ARTICLE: Roles of the PI3K/AKT/mTOR signalling pathways in neurodegenerative diseases and tumours

RETRACTED ARTICLE: Roles of the PI3K/AKT/mTOR signalling pathways in neurodegenerative diseases and tumours

Plant Responses to Abiotic Stresses and Rhizobacterial Biostimulants: Metabolomics and Epigenetics Perspectives

Shedding Light on the Dynamic Role of the “Target of Rapamycin” Kinase in the Fast-Growing C4 Species Setaria viridis, a Suitable Model for Biomass Crops

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