Target organ damage and cardiovascular risk factors among subjects with previously undiagnosed hypertension

Korhonen, Päivi; Kautiainen, Hannu; Järvenpää, Salme; Kantola, Ilkka

doi:10.1177/2047487312474530

Cited by 19 publications

(21 citation statements)

References 19 publications

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“…Therefore, evidence-based approach should include the BP and rate-pressure product for complete elimination of previously undiagnosed hypertension cases, which is becoming an important health problem around the world. In fact, a very recent article by Korhonen et al 5 has clearly documented that undiagnosed cases with hypertension are associated with nonignorable consequences that 1 of 5 patients is associated with subclinical target organ damage, including left ventricular hypertrophy.…”

Section: E28mentioning

confidence: 99%

Letter by Yalçin et al Regarding Article, “Left Ventricular Wall Thickness and the Presence of Asymmetric Hypertrophy in Healthy Young Army Recruits: Data from the LARGE Heart Study”

Yalçın

Abraham

Gottdiener

2013

Circ: Cardiovascular Imaging

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Section: E28mentioning

confidence: 99%

Letter by Yalçin et al Regarding Article, “Left Ventricular Wall Thickness and the Presence of Asymmetric Hypertrophy in Healthy Young Army Recruits: Data from the LARGE Heart Study”

Yalçın

Abraham

Gottdiener

2013

Circ: Cardiovascular Imaging

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“…This contrasts sharply with the patient populations in the studies referenced by Dr Yalçin, where participants were on average in their midforties. 3,4 We believe that subclinical hypertension is, therefore, much less likely to be a factor in our cohort than in those studies. Moreover, we did not observe an increase in our subjects' blood pressure readings after the training regime (indeed among those who developed asymmetrical wall thickening, diastolic blood pressure reduced: pre 120/84 versus post 115/61), confirming that the development of hypertension before the end of the follow-up period is unlikely to be of relevance.…”

mentioning

confidence: 56%

Response to Letter About Article, “Left Ventricular Wall Thickness and the Presence of Asymmetric Hypertrophy in Healthy Young Army Recruits: Data From the LARGE Heart Study”

Dweck

Lee

Prasher

et al. 2013

Circ: Cardiovascular Imaging

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e29That left ventricular growth occurs in response to exercise is, of course, well known. This relates to the increase in cardiac work, in turn a function of increased volume and pressure loading. As such, variation in the left ventricular hypertrophic response to exercise will result from differences in the external work undertaken, the cardiac work performed to deliver this work (the environmental stimulus to growth), and the genetic background of each individual. 1As such, we do not doubt that differences in the pressor response to exercise may have contributed to the differences in hypertrophy noted. With regret, we do not have data with respect to our recruits' blood pressure response to exercise, much of which was done in the field, making this difficult to acquire. However, this was not the intention of our article, whose key point was that such hypertrophy may commonly be asymmetrical in nature.2 Whether differences in pressure loading contributed to such differences in hypertrophic pattern cannot be ascertained from our study nor from those reported by Dr Yalçin et al.Concerning whether some forme fruste of hypertension existed in our subjects, we would note that all of the subjects studied were either in their teens or early twenties. This contrasts sharply with the patient populations in the studies referenced by Dr Yalçin, where participants were on average in their midforties. 3,4 We believe that subclinical hypertension is, therefore, much less likely to be a factor in our cohort than in those studies. Moreover, we did not observe an increase in our subjects' blood pressure readings after the training regime (indeed among those who developed asymmetrical wall thickening, diastolic blood pressure reduced: pre 120/84 versus post 115/61), confirming that the development of hypertension before the end of the follow-up period is unlikely to be of relevance. DisclosuresNone. (Circ Cardiovasc Imaging. 2013;6:e29.) Marc R. Dweck, MD, PhD Phong Teck Lee, MD

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“…A detailed description of the enrolment has been published previously [10,11]. A risk factor survey was mailed to all home-dwelling inhabitants (n = 2856) aged 45 -70 years, and 2085 (73 %) were willing to participate.…”

Section: Subjectsmentioning

confidence: 99%

Short stature in men is associated with subclinical peripheral arterial disease

Heikkilä

Venermo

Kautiainen

et al. 2016

Vasa

Self Cite

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Summary:Background: Peripheral arterial disease (PAD) affects approximately 202 million individuals around the world and is associated with a high risk of myocardial infarction, stroke and death. Although there is a clear inverse association between adult height and the risk of cardiovascular disease, little is known about the relationship between height and PAD. The aim of our study was to assess the relationship between subclinical PAD and height. Patients and methods: In a cross-sectional cardiovascular risk factor study in southwestern Finland, ankle brachial index (ABI) and other risk factors were measured from a total of 972 cardiovascular risk subjects derived from the general population. None of them had previously diagnosed diabetes, cardiovascular or renal disease or intermittent claudication. Subjects with an ABI ≤ 0.90 were categorized as having subclinical PAD. Results: The average age of the study subjects was 58.1 ± 6.7 years for men and 58.8 ± 6.9 years for women. The prevalence of subclinical PAD was 5 % (95 % CI 3 % − 7 %) (23/455) among men and 5 % (95 % CI 3 %−7 %) (26/517) among women. The mean ABI among men and women was 1.09 ± 0.12 and 1.08 ± 0.12, respectively. In men, there was an inverse association between height and the prevalence of subclinical PAD (p < 0.001) along with a positive association between height and ABI values (p < 0.001). In a multivariate model, height, age and current smoking status remained independent factors that were associated with subclinical PAD in men, whereas in women, only pulse pressure was associated with subclinical PAD. Conclusions: Short stature in men is associated with subclinical PAD and lower ABI values.

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Target organ damage and cardiovascular risk factors among subjects with previously undiagnosed hypertension

Abstract: Among subjects with previously undiagnosed hypertension, one in five patients had evidence of subclinical target organ damage, and three in four patients may be regarded as having high cardiovascular risk.

Cited by 19 publications

References 19 publications

Letter by Yalçin et al Regarding Article, “Left Ventricular Wall Thickness and the Presence of Asymmetric Hypertrophy in Healthy Young Army Recruits: Data from the LARGE Heart Study”

Letter by Yalçin et al Regarding Article, “Left Ventricular Wall Thickness and the Presence of Asymmetric Hypertrophy in Healthy Young Army Recruits: Data from the LARGE Heart Study”

Response to Letter About Article, “Left Ventricular Wall Thickness and the Presence of Asymmetric Hypertrophy in Healthy Young Army Recruits: Data From the LARGE Heart Study”

Short stature in men is associated with subclinical peripheral arterial disease

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