2017
DOI: 10.1111/hae.13215
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Target plasma factor levels for personalized treatment in haemophilia: a Delphi consensus statement

Abstract: We have generated, by expert consensus, target plasma levels of factor concentrate to be used to tailor treatment for persons with haemophilia.

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Cited by 65 publications
(69 citation statements)
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“…The Delphi methodology uses a series of surveys distributed to a group of individuals to ascertain consensus on statements relating to a domain of expertise. [22][23][24][25][26] After three successive survey rounds, a definitive list of statements that did and did not derive consensus is generated.…”
Section: The Delphi Methodologymentioning
confidence: 99%
See 1 more Smart Citation
“…The Delphi methodology uses a series of surveys distributed to a group of individuals to ascertain consensus on statements relating to a domain of expertise. [22][23][24][25][26] After three successive survey rounds, a definitive list of statements that did and did not derive consensus is generated.…”
Section: The Delphi Methodologymentioning
confidence: 99%
“…Finally, while the benefits of using Delphi methodology for generating consensus are well documented, [22][23][24][25][26] this approach may have also avoided the potential bias that could have occurred using a face-to-face assessments, utilized in other consensus methodologies. Finally, while the benefits of using Delphi methodology for generating consensus are well documented, [22][23][24][25][26] this approach may have also avoided the potential bias that could have occurred using a face-to-face assessments, utilized in other consensus methodologies.…”
Section: % (Strong Consensus)mentioning
confidence: 99%
“…9 Additional literature reviews were conducted to identify pertinent evidence for each clinical and patient-relevant outcome. A new model was proposed that enables patients to achieve specific milestones in a stepwise fashion, culminating in a progressive definition of cure.…”
Section: Me Thodsmentioning
confidence: 99%
“…As well as excessive bleeding following surgery or trauma, patients with haemophilia A may experience spontaneous bleeding (with no apparent or known cause), which, if untreated, can be life‐threatening . For patients with severe haemophilia A, the World Federation of Hemophilia recommends prophylaxis with factor VIII (FVIII) infusions, with dose calculations aiming to maintain a predetermined target FVIII trough level . This approach is based on the pharmacokinetics (PK) of FVIII, that is the fate of FVIII once it enters the body.…”
Section: Introductionmentioning
confidence: 99%