Target Role of Langerhans Cells in Mycosis Fungoides: Transmission and Immuno‐Electron Microscopic Studies

Rowden, Geoffrey; Phillips, Terry M.; Lewis, M. G.; Wilkinson, Ralph D.

doi:10.1111/j.1600-0560.1979.tb01159.x

Cited by 88 publications

(34 citation statements)

References 42 publications

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“…Epidermal association of proliferating clonal CD4 tumor cells surrounding a central LC 6 may represent an interaction with immature DCs driven by DC uptake and presentation of antigen(s) derived from apoptotic cells. In situ studies have demonstrated that LCs in the epidermis of patients with tumor-stage CTCL contain apoptotic cells associated with IL-10-positive cells, suggesting that in vivo uptake of apoptotic cells may parallel the in vitro induction of IL-10-producing CTCL cells.…”

Section: Discussionmentioning

confidence: 99%

“…CTCL is a clonal malignancy 1 of CD4 ϩ 2 helper T cells 3,4 expressing a memory phenotype 5 and with a propensity to accumulate in the epidermis in proximity to Langerhans cells 6 (LCs), which are immature dendritic cells (DCs). 7 Epidermal association of CTCL cells with LCs is so distinctive that it is considered a diagnostic hallmark of the malignancy known as Pautrier microabscesses.…”

Section: Introductionmentioning

confidence: 99%

“…7 Epidermal association of CTCL cells with LCs is so distinctive that it is considered a diagnostic hallmark of the malignancy known as Pautrier microabscesses. 6 Proliferation of CTCL cells in the epidermis, in association with LCs, has suggested that the tumor cells' growth is stimulated by LC-mediated antigen presentation and has led to the hypothesis that CTCL is a disease of chronic antigen stimulation whose growth is promoted by LC presentation of virally, bacterially, or chemically modified peptides. 8,9 Despite the presence in CTCL patients of circulating populations of CD8 T cells 10 that recognize major histocompatibility complex (MHC) class 1-displayed tumor-specific peptides derived from the malignant T cell clonotypic T-cell receptor (TCR), 11,12 the disease persists and disseminates, indicating that the malignancy commonly evades immunosurveillance.…”

Section: Introductionmentioning

confidence: 99%

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Cutaneous T-cell lymphoma: malignant proliferation of T-regulatory cells

Berger

Tigelaar

Cohen

et al. 2005

Blood

223

174

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Cutaneous T-cell lymphoma: malignant proliferation of T-regulatory cells

Berger

Tigelaar

Cohen

et al. 2005

Blood

223

174

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“…Langerhans' cells and indeterminate cells show a close topographical relation to the lymphoid cells [28], Both cell types are lying in the same cell nests and have close membrane contacts over a certain distance. This frequent juxtaposition is probably the expression of a functional interaction between the two cell types.…”

Section: Discussionmentioning

confidence: 99%

Microenvironment of Woringer-Kolopp’s Disease

1982

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A localized form of ‘Pagetoid reticulosis’ (Woringer-Kolopp’s disease) is described morphologically. It can be shown that ultrastructurally the ‘Pagetoid cells’ are heterogenic and that different cell types can be distinguished: there are lymphoid cells, which often look like Lutzner cells, and nonlymphoid cells which can be characterized as indeterminate cells or Langerhans’ cells. Often a close topographical relation between lymphoid and nonlymphoid cells can be demonstrated. This finding is suggestive for a functional interaction between the lymphoid cells, which are most probably T cells, and indeterminate cells and Langerhans’ cells, which are known to be important for the thymus-dependent immune reaction. The presence of the nonlymphoid cell population in the epidermis in Woringer-Kolopp’s disease seems to build up the specific microenvironment for lymphoid cell reaction.

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“…Long-lived recirculating T lymphocytes monitor internal epithelial surfaces [ I , 191, and it has been postulated that a subclass of recirculating lymphocytes home in on the skin epithelium in a similar fashion [23]. Persistence of antigen, perhaps associated with abnormalities of Langerhans' cells, might increase both the localization and proliferation of this lymphocyte subclass in the skin [21,24]. Environmental agents, which could be a source of persistent antigen, have been implicated tentatively in the genesis of mycosis fungoides [12].…”

Section: Discussionmentioning

confidence: 99%

Canine Epidermotropic Lymphoproliferative Disease Resembling Pagetoid Reticulosis in Man

Johnson

Patterson

1981

Vet Pathol

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Abstract. Gross lesions in a dog with cutaneous lymphoproliferative disease involved oral mucosa, and footpad and nasal epithelia. The lesions were vesicles, ulcers, erythematous papules, and plaques. The distinctive histologic feature was the predominantly intraepithelial proliferation of a monomorphous population of atypical mononuclear cells, many with bizarre convoluted nuclei. Ultrastructurally the mononuclear cells had few cytoplasmic organelles and resembled lymphocytes. These features distinguish the lesion from the usual canine cutaneous lymphosarcoma and from the canine equivalent of mycosis fungoides. The histology resembles that of pagetoid reticulosis in man.An unusual form of cutaneous lymphoproliferative disease, resembling mycosis fungoides in man, has been described in the dog [ 14, 16,221. Mycosis fungoides is a tumor of thymus-derived lymphocytes that arises in the skin [ 10,11,17,18]. It is slowly progressive, spreading to lymph nodes and internal organs late in the course of the disease [4,17].Mycosis fungoides has three characteristic histologic features [ 1 1, 171. Firstly, the cutaneous cell infiltrate is pleomorphic, with plasma cells, eosinophils and histiocytes accompanying the neoplastic T lymphocytes. Secondly, many of the neoplastic T lymphocytes have hyperchromatic and convoluted nuclei. The cells have been named mycosis cells [17], although they also occur in inflammatory skin conditions [13]. The third feature, considered almost pathognomonic for mycosis fungoides, is the presence of Pautrier's microabscesses, small intraepithelial clusters of the proliferating tumor cells [17, 181. Pagetoid reticulosis, also known as Woringer-Kolopp disease or epidermotropic reticulosis, is a rare skin tumor in man, considered by many to be another manifestation of cutaneous T-cell lymphoma [2,3,5,9,16,25], perhaps a variant of mycosis fungoides [7, 161. The histiocyte and Merkel cell have been proposed as alternate progenitors [6,20], but recently the tumor cells were shown to have T-lymphocyte membrane properties [3]. Clinically, the disease may be localized or generalized [3, 487 488Johnson and Patterson 251. Histologically, both forms are characterized by the proclivity of the tumor cells to multiply within the confines of the surface epithelium [2,3,5,9,16,251. Case HistoryA 9-year-old female Scottish Terrier had a protracted disease affecting mainly footpad and oral epithelia. The lesions had not responded to intermittent treatment with corticosteroids and antibiotics during the preceding I2 months. Clinical examination showed irregular smooth papules aggregated into plaques on the buccal and pharyngeal mucosa. Over the epiglottis the lesions were vesicular. Well-demarcated irregular plaques on the dorsum of the tongue had a rough grey-white central area with a smooth erythematous periphery. The epithelium on the volar surface of the front and to a lesser extent the rear footpads was irregularly eroded and hemorrhagic. Adjacent areas were covered with thick grey crust. An area of alopeci...

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Target Role of Langerhans Cells in Mycosis Fungoides: Transmission and Immuno‐Electron Microscopic Studies

Cited by 88 publications

References 42 publications

Cutaneous T-cell lymphoma: malignant proliferation of T-regulatory cells

Cutaneous T-cell lymphoma: malignant proliferation of T-regulatory cells

Microenvironment of Woringer-Kolopp’s Disease

Canine Epidermotropic Lymphoproliferative Disease Resembling Pagetoid Reticulosis in Man

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