2024
DOI: 10.3390/diseases12050081
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Target Role of Monocytes as Key Cells of Innate Immunity in Rheumatoid Arthritis

Diana I. Salnikova,
Nikita G. Nikiforov,
Anton Y. Postnov
et al.

Abstract: Rheumatoid arthritis (RA) is a chronic, systemic, and inflammatory autoimmune condition characterized by synovitis, pannus formation (with adjacent bone erosion), and joint destruction. In the perpetuation of RA, fibroblast-like synoviocytes (FLSs), macrophages, B cells, and CD4+ T-cells—specifically Th1 and Th17 cells—play crucial roles. Additionally, dendritic cells, neutrophils, mast cells, and monocytes contribute to the disease progression. Monocytes, circulating cells primarily derived from the bone marr… Show more

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Cited by 5 publications
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