Target selectivity of cholesterol-phosphatidylcholine liposome loaded with phthalocyanine for breast cancer diagnosis and treatment by photodynamic therapy

Jayme, Cristiano Ceron; Rezende, Nayara; Fernandes, Daniela Silvestrini; Paula, Leonardo Barcelos de; Castro, Bárbara Gimenes de; Takahashi, Luandra Aparecida Unten; Tedesco, Antônio Cláudio

doi:10.1016/j.pdpdt.2022.102992

Cited by 4 publications

(3 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, the substitution of Chol might enhance targeted delivery of the photosensitizer to cancer cells, because it is known that cancer cells are keen to attract as much Chol as possible through expressing more LDL receptors [34][35][36]. In the field, the encapsulation of Pcs in liposome-based nanoparticles is among the most common approaches for the targeted delivery of photosensitizers [16][17][18][19][20][21][22]. In this approach, the photosensitizers were released during the lipid exchange with lipoproteins, they were attached to lipoproteins, and such attachment, particularly to LDLs, helps to the selective targeting of cancer cells [23][24][25][26][27][28][29].…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Graphene Oxide/Cholesterol-Substituted Zinc Phthalocyanine Composites with Enhanced Photodynamic Therapy Properties

Erden

2023

Materials

View full text Add to dashboard Cite

In the present work, cholesterol (Chol)-substituted zinc phthalocyanine (Chol-ZnPc) and its composite with graphene oxide (GO) were prepared for photodynamic therapy (PDT) applications. Briefly, Chol-substituted phthalonitrile (Chol-phthalonitrile) was synthesized first through the substitution of Chol to the phthalonitrile group over the oxygen bridge. Then, Chol-ZnPc was synthesized by a tetramerization reaction of Chol-phthalonitrile with ZnCl2 in a basic medium. Following this, GO was introduced to Chol-ZnPc, and the successful preparation of the samples was verified through FT-IR, UV–Vis, 1H-NMR, MALDI-TOF MS, SEM, and elemental analysis. Regarding PDT properties, we report that Chol-ZnPc exhibited a singlet oxygen quantum yield (Φ∆) of 0.54, which is slightly lower than unsubstituted ZnPc. Upon introduction of GO, the GO/Chol-ZnPc composite exhibited a higher Φ∆, about 0.78, than that of unsubstituted ZnPc. Moreover, this enhancement was realized with a simultaneous improvement in fluorescence quantum yield (ΦF) to 0.36. In addition, DPPH results suggest low antioxidant activity in the composite despite the presence of GO. Overall, GO/Chol-ZnPc might provide combined benefits for PDT, particularly in terms of image guidance and singlet oxygen generation.

show abstract

Section: Resultsmentioning

confidence: 99%

“…One way to resolve this involves the encapsulation of Pcs in liposome-based nanoparticles for their targeted delivery [16][17][18][19][20][21][22]. In that case, liposomes release Pcs during lipid exchange with lipoproteins, and then Pcs are bound to lipoproteins, which carry cholesterol (Chol) through the bloodstream [23][24][25].…”

Section: Introductionmentioning

confidence: 99%

Graphene Oxide/Cholesterol-Substituted Zinc Phthalocyanine Composites with Enhanced Photodynamic Therapy Properties

Erden

2023

Materials

View full text Add to dashboard Cite

show abstract

“…Liposomes are spherical vesicles composed of lipid bilayers, primarily made from natural lipid molecules such as lecithin (67) and cholesterol (68). Their particle size typically ranges between 1nm and 10 mm.…”

Section: Liposomesmentioning

confidence: 99%

Research progress of nanovaccine in anti-tumor immunotherapy

Yao,

Liu,

Qian

et al. 2023

Front. Oncol.

View full text Add to dashboard Cite

Tumor vaccines aim to activate dormant or unresponsive tumor-specific T lymphocytes by using tumor-specific or tumor-associated antigens, thus enhancing the body’s natural defense against cancer. However, the effectiveness of tumor vaccines is limited by the presence of tumor heterogeneity, low immunogenicity, and immune evasion mechanisms. Fortunately, multifunctional nanoparticles offer a unique chance to address these issues. With the advantages of their small size, high stability, efficient drug delivery, and controlled surface chemistry, nanomaterials can precisely target tumor sites, improve the delivery of tumor antigens and immune adjuvants, reshape the immunosuppressive tumor microenvironment, and enhance the body’s anti-tumor immune response, resulting in improved efficacy and reduced side effects. Nanovaccine, a type of vaccine that uses nanotechnology to deliver antigens and adjuvants to immune cells, has emerged as a promising strategy for cancer immunotherapy due to its ability to stimulate immune responses and induce tumor-specific immunity. In this review, we discussed the compositions and types of nanovaccine, and the mechanisms behind their anti-tumor effects based on the latest research. We hope that this will provide a more scientific basis for designing tumor vaccines and enhancing the effectiveness of tumor immunotherapy.

show abstract

Site-specific delivery of cisplatin and paclitaxel mediated by liposomes: A promising approach in cancer chemotherapy

Zou

2023

Environmental Research

View full text Add to dashboard Cite

Target selectivity of cholesterol-phosphatidylcholine liposome loaded with phthalocyanine for breast cancer diagnosis and treatment by photodynamic therapy

Cited by 4 publications

References 25 publications

Graphene Oxide/Cholesterol-Substituted Zinc Phthalocyanine Composites with Enhanced Photodynamic Therapy Properties

Graphene Oxide/Cholesterol-Substituted Zinc Phthalocyanine Composites with Enhanced Photodynamic Therapy Properties

Research progress of nanovaccine in anti-tumor immunotherapy

Site-specific delivery of cisplatin and paclitaxel mediated by liposomes: A promising approach in cancer chemotherapy

Contact Info

Product

Resources

About