Target Sign in Woman With Abdominal Pain and Systemic Lupus Erythematosus Treated With Plasma Exchange

Padilla, Kiber Arturo González; Delgado, Dionicio Angel Galarza; Elizondo, Mario Alberto Garza; Valerio, J. A. Esquivel; Arana-Guajardo, Ana Cecilia

doi:10.1016/j.reumae.2015.11.019

Cited by 1 publication

(1 citation statement)

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“… 3 , 4 Treatment is tailored to disease severity, and although most patients are successfully treated with glucocorticoid therapy and have an excellent prognosis, immunosuppression and occasionally intravenous immunoglobulin and plasmapheresis are used in severe cases. 2 , 4 , 6 , 7 We describe a unique case of a patient with SLE complicated by severe LE, intractable GI bleeding, disseminated intravascular coagulation (DIC), and warm autoimmune hemolytic anemia (WAHA). To the knowledge of the authors, this is the first case reported of LE complicated by intractable GI bleeding with WAHA.…”

Section: Introductionmentioning

confidence: 99%

Severe Lupus Enteritis Complicated by Intractable Gastrointestinal Hemorrhage

Thomas,

Smithhart,

Chopra

et al. 2023

ACG Case Rep J

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Lupus enteritis (LE) is a rare presentation of systemic lupus erythematosus manifesting with nonspecific symptoms, laboratory derangements, and imaging findings. Rarely, LE may progress to bowel perforation, hemorrhage, and even death. Treatment with systemic glucocorticoids often results in rapid clinical improvement, but patients may require further immunosuppression. We present a case of severe LE complicated by life-threatening intractable gastrointestinal hemorrhage and warm autoimmune hemolytic anemia refractory to glucocorticoids and ultimately requiring massive transfusions, intravenous immunoglobulin, and plasmapheresis. This case illustrates the importance of early specialist involvement and treatment with intravenous immunoglobulin and plasmapheresis for severe, life-threatening LE.

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